Selected honey as a multifaceted antimicrobial agent: review of compounds, mechanisms, and research challenges DOI
António Machado, Duarte Toubarro, José Baptista

et al.

Future Microbiology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 22

Published: April 28, 2025

Honey, derived from floral nectar, has been valued for its nutritional and therapeutic properties, with recent studies emphasizing broad-spectrum antimicrobial potential, especially against resistance (AMR). Honey's activity stems unique composition, including high sugar content, low pH, bioactive compounds like hydrogen peroxide, methylglyoxal (MGO), phenolic compounds. Distinct honey types, such as Manuka, Sidr, Tualang, demonstrate varying effects based on their botanical geographical origins. Manuka honey, rich in MGO, is notably effective multidrug-resistant pathogens, while Sidr heather honeys excel biofilm inhibition antioxidative properties. Bioactive components, phenolics, flavonoids, enzymes, peptides, disrupt microbial membranes, inhibit metabolic pathways, induce oxidative stress. Advanced analytical techniques HPLC GC-MS have identified these compounds, though gaps remain understanding secondary metabolites synergistic actions. This review highlights honey's potential a sustainable resource, the need standardization, clinical validation, interdisciplinary research. Honey represents promising solution to AMR offers opportunities integration into modern medicine healthcare strategies.

Language: Английский

Rosaceae Honey: Antimicrobial Activity and Prebiotic Properties DOI Creative Commons
Francesca Coppola, Manar Abdalrazeq, Florinda Fratianni

et al.

Antibiotics, Journal Year: 2025, Volume and Issue: 14(3), P. 298 - 298

Published: March 13, 2025

Background: Flowering members of the globally diffused Rosaceae family include popular plants, such as apple, almond, and cherry, which play a fundamental role honeybee nectariferous polleniferous agents. Through production honey, these plants can also an indirect in prevention treatment many diseases, including infections, fighting occurrence resistant microorganisms, concurrently stimulating growth beneficial bacteria. Objectives: This study focused on effect some plants’ hawthorn, raspberry, against pathogens Acinetobacter baumannii, Escherichia coli, Klebsiella pneumoniae, Listeria monocytogenes, Pseudomonas aeruginosa, Staphylococcus aureus. Results: Results demonstrated honey’s ability to impair swimming motility. A crystal violet test indicated that honey could inhibit formation stabilization biofilms, with inhibition rates up 59.43% for immature biofilms (showed by apple A. baumannii) 39.95% sessile bacterial cells mature (when we used cherry S. aureus). In 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, were most effective inhibiting cell metabolism both (56.47% vs. K. pneumoniae) (54.36% baumannii). Honey stimulated Lactobacillus bulgaricus, Lacticaseibacillus casei Shirota, gasseri, plantarum, rhamnosus; almond significantly increased vitro adhesion capacity L. bulgaricus Shirota. Tests probiotic supernatants biofilm pathogens. Conclusions: Our results encourage further studies assess potential application food preservation health field, it fight antimicrobial resistance clinical pathogens, potentially enhance host’s gut wellness. The use nanotechnological biotechnological approaches be suggested too.

Language: Английский

Citations

2

Characterization of the Prevalence and Antibiotic Resistance of Staphylococcus Species in an Exercise Facility in Central Kentucky, USA DOI Creative Commons

Lilian Jeptoo Kiborus,

S. Travis Altheide, Jason W. Marion

et al.

Hygiene, Journal Year: 2025, Volume and Issue: 5(1), P. 2 - 2

Published: Jan. 14, 2025

The spread of methicillin-resistant Staphylococcus aureus (MRSA) in community settings, including fitness/exercise centers, remains relevant for public health. MRSA, a cause severe infections some, can be transmitted through shared equipment and skin contact. Understanding its prevalence the frequency antibiotic resistance such environments useful informing hygiene intervention strategies. For investigating, multiple environmental swabs were collected from 14 different sites within fitness facility, locker rooms. Samples characterizing staphylococci (including MRSA), E. coli, carbapenem-resistant Enterobacterales (CRE). Isolated colonies identified biochemically evaluated resistance. Logistic regression was applied to assess risk across surfaces. Among 42 samples, highest spp. on room S. prevalent floors benches. Non-S. species, as saprophyticus haemolyticus, common. Resistance oxacillin penicillin widespread, particularly among non-S. species. coli detected once, CRE not detected. Fitness center surfaces harbor staphylococci, MRSA. results obtained corroborate other studies finding notable Hygiene improvements, personal actions, are essential reducing transmission risks.

Language: Английский

Citations

0

Brazilian Organic Honeydew Reduces In Vitro and In Vivo Periodontal Disease-Related Subgingival Biofilm DOI Creative Commons
Diego Romário Silva, Marcelo Franchin, Bruno Bueno‐Silva

et al.

Foods, Journal Year: 2025, Volume and Issue: 14(6), P. 997 - 997

Published: March 14, 2025

We investigated the antimicrobial properties and effects on bone resorption of Brazilian organic honeydew (OHD) from Bracatinga tree (Mimosa scabrella Benth.), a rare honey certified with Denomination Origin, using periodontal disease model. Antibiofilm activity was assessed subgingival biofilm adhered to Calgary device. Biofilms were treated OHD, chlorhexidine (0.12%), or vehicle twice daily for 1 min starting day 3, at concentrations 2× 10× minimum inhibitory concentration (MIC). employed ligature-induced chronic model challenged it Porphyromonas gingivalis in C57BL/6 mice. The chemical profile OHD analyzed LC-ESI-IT-MS/MS. Results evaluated by measuring loss microbial composition ligature through DNA-DNA hybridization. demonstrated significant against P. (MIC 4%, MBC 6%) reduced viability 80% vitro. In vivo, decreased populations associated disease. Chemical analysis identified seven compounds including five flavonoids two lignans. This Atlantic Forest exhibits strong potential as functional food oral health, offering promising alternative control prevention

Language: Английский

Citations

0

Selected honey as a multifaceted antimicrobial agent: review of compounds, mechanisms, and research challenges DOI
António Machado, Duarte Toubarro, José Baptista

et al.

Future Microbiology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 22

Published: April 28, 2025

Honey, derived from floral nectar, has been valued for its nutritional and therapeutic properties, with recent studies emphasizing broad-spectrum antimicrobial potential, especially against resistance (AMR). Honey's activity stems unique composition, including high sugar content, low pH, bioactive compounds like hydrogen peroxide, methylglyoxal (MGO), phenolic compounds. Distinct honey types, such as Manuka, Sidr, Tualang, demonstrate varying effects based on their botanical geographical origins. Manuka honey, rich in MGO, is notably effective multidrug-resistant pathogens, while Sidr heather honeys excel biofilm inhibition antioxidative properties. Bioactive components, phenolics, flavonoids, enzymes, peptides, disrupt microbial membranes, inhibit metabolic pathways, induce oxidative stress. Advanced analytical techniques HPLC GC-MS have identified these compounds, though gaps remain understanding secondary metabolites synergistic actions. This review highlights honey's potential a sustainable resource, the need standardization, clinical validation, interdisciplinary research. Honey represents promising solution to AMR offers opportunities integration into modern medicine healthcare strategies.

Language: Английский

Citations

0