Gut microbiota and its impact on critical illness
Current Opinion in Critical Care,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 27, 2025
Purpose
of
review
This
narrative
discusses
the
mechanisms
connecting
gut
dysbiosis
to
adverse
clinical
outcomes
in
critically
ill
patients
and
explores
potential
therapeutic
strategies.
Recent
findings
In
recent
years,
study
microbiota
ICUs
has
gained
attention
because
its
effects
on
patient
outcomes.
Critically
often
face
severe
conditions,
which
can
compromise
their
immune
systems
lead
opportunistic
infections
from
bacteria
typically
harmless
healthy
individuals.
The
relationship
between
aggressive
medical
treatments
composition
remains
unclear.
Dysbiosis,
characterized
by
reduced
microbial
diversity
loss
beneficial
bacteria,
prolonged
immunosuppression
increased
pathogenic
risks,
contributing
organ
failure.
advancements
multiomics
technologies
have
enhanced
understanding
host–microbe
interactions
implications
critical
care.
Summary
plays
an
important
role
shaping
for
patients.
According
evidence,
alterations
lung
are
associated
with
disease
severity,
mortality,
overall
recovery.
Evolving
research
opens
possibilities
personalized
medicine
tailoring
based
individual
profiles,
though
applications
still
developing.
Language: Английский
Role and significance of virus-bacteria interactions in disease progression
Journal of Applied Microbiology,
Journal Year:
2024,
Volume and Issue:
135(6)
Published: June 1, 2024
Understanding
disease
pathogenesis
caused
by
bacteria/virus,
from
the
perspective
of
individual
pathogen
has
provided
meaningful
insights.
However,
as
viral
and
bacterial
counterparts
might
inhabit
same
infection
site,
it
becomes
crucial
to
consider
their
interactions
contributions
in
onset
progression.
The
objective
review
is
highlight
importance
considering
both
agents
during
course
coinfection.
provides
a
unique
on
general
theme
virus-bacteria
interactions,
which
either
lead
colocalized
infections
that
are
restricted
one
anatomical
niche,
or
systemic
have
effect
human
host.
sequence,
nature,
underlying
mechanisms
certain
been
elaborated
with
relevant
examples
literature.
It
also
attempts
address
various
applied
aspects,
including
diagnostic
therapeutic
strategies
for
well
coinfections.
aims
aid
researchers
comprehending
intricate
interplay
between
virus
bacteria
progression,
thereby
enhancing
understanding
current
methodologies
empowering
development
novel
health
care
tackle
Language: Английский
The bronchiectasis microbiome: current understanding and treatment implications
Current Opinion in Pulmonary Medicine,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 4, 2024
Purpose
of
review
Advances
in
DNA
sequencing
and
analysis
the
respiratory
microbiome
highlight
its
close
association
with
bronchiectasis
phenotypes,
revealing
fresh
opportunities
for
diagnosis,
stratification,
personalized
clinical
intervention.
An
under-recognized
condition,
is
increasingly
subject
recent
large-scale,
multicentre,
longitudinal
studies
including
detailed
microbiome.
In
this
review,
we
summarize
progress
our
understanding
within
context
potential
use
treatment
decisions.
Recent
findings
Diverse
profiles
exist
bronchiectasis,
line
established
disease
heterogeneity
response.
Classical
microbiology
has
Pseudomonas
aeruginosa
Haemophilus
influenza
as
two
microbial
markers
disease,
while
holistic
uncovered
important
associations
less
common
bacterial
taxa
commensal
an/or
pathobiont
species,
emerging
role
fungal
mycobiome,
virome,
interactome.
Integration
airway
microbiomes
other
high-dimensional
biological
datasets
holds
significant
promise
to
determining
treatable
traits
mechanisms
related
Summary
The
an
key
area
study
implications
influencing
decisions
ultimately
improving
patient
outcomes.
Language: Английский