Current Opinion in Critical Care, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 27, 2025
Purpose of review This narrative discusses the mechanisms connecting gut dysbiosis to adverse clinical outcomes in critically ill patients and explores potential therapeutic strategies. Recent findings In recent years, study microbiota ICUs has gained attention because its effects on patient outcomes. Critically often face severe conditions, which can compromise their immune systems lead opportunistic infections from bacteria typically harmless healthy individuals. The relationship between aggressive medical treatments composition remains unclear. Dysbiosis, characterized by reduced microbial diversity loss beneficial bacteria, prolonged immunosuppression increased pathogenic risks, contributing organ failure. advancements multiomics technologies have enhanced understanding host–microbe interactions implications critical care. Summary plays an important role shaping for patients. According evidence, alterations lung are associated with disease severity, mortality, overall recovery. Evolving research opens possibilities personalized medicine tailoring based individual profiles, though applications still developing.
Language: Английский