Tremella fuciformis Berk Alleviated Atherosclerosis Symptoms via Nuclear Factor-Kappa B-Mediated Inflammatory Response in ApoE−/− Mice DOI Open Access
Yihao Dong,

Q. X. Zhang,

Rui Xie

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 17(1), P. 160 - 160

Published: Dec. 31, 2024

Background: Atherosclerosis, a persistent inflammatory disease marked by the presence of atherosclerotic plaques or fibrous plaques, is significant contributor to onset development cardiovascular disease. Tremella fuciformis Berk contains various active ingredients that have anti-inflammatory, antioxidant, and hypolipidemic properties. Nevertheless, potential effects T. on atherosclerosis not been systematically reported. Method: In this study, ApoE−/− mice were employed as models caused high-fat diet (HFD) investigate effect fuciformis. Gut microbiota serum metabolism analysis performed elucidate mechanism for its anti-atherosclerosis effects. Results: significantly decreased aortic root wall thickness area lipid droplets, regulated levels, inhibited fat accumulation improve lesions. Furthermore, altered metabolite (including diethyl phthalate succinate) abundance microbiota, such Coriobacteriaceae_UCG-002 Alistipes, suppressed response ameliorate via nuclear factor-kappa B (NF-κB)-mediated in HFD-induced mice. Conclusions: These results offer theoretical basis data support strategy treating atherosclerosis.

Language: Английский

Enhancing oral tolerance of Penaeus vannamei by covalent modification of fucoidan: insights from intestinal microecology DOI

Qiaozhen Liu,

Songyi Lin,

Kexin Liu

et al.

Food Bioscience, Journal Year: 2024, Volume and Issue: 62, P. 105361 - 105361

Published: Oct. 28, 2024

Language: Английский

Citations

1
Tremella fuciformis Berk Alleviated Atherosclerosis Symptoms via Nuclear Factor-Kappa B-Mediated Inflammatory Response in ApoE−/− Mice DOI Open Access
Yihao Dong,

Q. X. Zhang,

Rui Xie

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 17(1), P. 160 - 160

Published: Dec. 31, 2024

Background: Atherosclerosis, a persistent inflammatory disease marked by the presence of atherosclerotic plaques or fibrous plaques, is significant contributor to onset development cardiovascular disease. Tremella fuciformis Berk contains various active ingredients that have anti-inflammatory, antioxidant, and hypolipidemic properties. Nevertheless, potential effects T. on atherosclerosis not been systematically reported. Method: In this study, ApoE−/− mice were employed as models caused high-fat diet (HFD) investigate effect fuciformis. Gut microbiota serum metabolism analysis performed elucidate mechanism for its anti-atherosclerosis effects. Results: significantly decreased aortic root wall thickness area lipid droplets, regulated levels, inhibited fat accumulation improve lesions. Furthermore, altered metabolite (including diethyl phthalate succinate) abundance microbiota, such Coriobacteriaceae_UCG-002 Alistipes, suppressed response ameliorate via nuclear factor-kappa B (NF-κB)-mediated in HFD-induced mice. Conclusions: These results offer theoretical basis data support strategy treating atherosclerosis.

Language: Английский

Citations

0