Interplay of Transcriptomic Regulation, Microbiota, and Signaling Pathways in Lung and Gut Inflammation-Induced Tumorigenesis DOI Creative Commons
Beatriz Andrea Otálora-Otálora, César Payán‐Gómez, Juan Javier López Rivera

et al.

Cells, Journal Year: 2024, Volume and Issue: 14(1), P. 1 - 1

Published: Dec. 24, 2024

Inflammation can positively and negatively affect tumorigenesis based on the duration, scope, sequence of related events through regulation signaling pathways. A transcriptomic analysis five pulmonary arterial hypertension, twelve Crohn’s disease, ulcerative colitis high throughput sequencing datasets using R language specialized libraries gene enrichment analyses identified a regulatory network in each inflammatory disease. IRF9 LINC01089 hypertension are to pathways like MAPK, NOTCH, human papillomavirus, hepatitis c infection. ZNF91 TP53TG1 disease PPAR, metabolic ZNF91, VDR, DLEU1, SATB2-AS1, AMPK, The activation might be interaction characteristic microbiota with lung gut cell receptors present membrane rafts complexes. highlights impact several coding non-coding RNAs, suggesting their relationship unlocking phenotypic plasticity for acquisition hallmarks cancer during adaptation phenotypes.

Language: Английский

Interplay of Transcriptomic Regulation, Microbiota, and Signaling Pathways in Lung and Gut Inflammation-Induced Tumorigenesis DOI Creative Commons
Beatriz Andrea Otálora-Otálora, César Payán‐Gómez, Juan Javier López Rivera

et al.

Cells, Journal Year: 2024, Volume and Issue: 14(1), P. 1 - 1

Published: Dec. 24, 2024

Inflammation can positively and negatively affect tumorigenesis based on the duration, scope, sequence of related events through regulation signaling pathways. A transcriptomic analysis five pulmonary arterial hypertension, twelve Crohn’s disease, ulcerative colitis high throughput sequencing datasets using R language specialized libraries gene enrichment analyses identified a regulatory network in each inflammatory disease. IRF9 LINC01089 hypertension are to pathways like MAPK, NOTCH, human papillomavirus, hepatitis c infection. ZNF91 TP53TG1 disease PPAR, metabolic ZNF91, VDR, DLEU1, SATB2-AS1, AMPK, The activation might be interaction characteristic microbiota with lung gut cell receptors present membrane rafts complexes. highlights impact several coding non-coding RNAs, suggesting their relationship unlocking phenotypic plasticity for acquisition hallmarks cancer during adaptation phenotypes.

Language: Английский

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