Association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and Helicobacter pylori infection

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 12, 2025

Evidence on the association between non-high-density lipoprotein cholesterol to high-density ratio (NHHR) and Helicobacter pylori (H. pylori) infection remains limited. This study investigates this correlation based U.S. population. cross-sectional research included data 834 participants from National Health Nutrition Examination Survey 1999-2000. The NHHR H. was examined using logistic regression models, restricted cubic spline (RCS) curve subgroup analyses. Individuals with exhibited significantly higher value. A significant positive observed across all three even after adjusting for potential confounders, a stronger noted in males, individuals under 60 years of age, non-Hispanic White participants. These findings suggest may act as non-invasive biomarker detecting populations.

Language: Английский

Association of Helicobacter pylori Infection and Risk of Dyslipidemia: A Systematic Review and Meta‐Analysis

JGH Open, Journal Year: 2025, Volume and Issue: 9(3)

Published: March 1, 2025

ABSTRACT Background Although Helicobacter pylori ( H. ) infections are widespread throughout the world, it is yet unknown whether they linked to systemic illnesses like dyslipidemia. The purpose of this systematic review and meta‐analysis was examine connection between lipid metabolism infection, with a particular emphasis on how affects Methods We conducted thorough search up until October 10, 2024, across databases such as PubMed, Web Science, Embase. Studies that reported profiles in both ‐infected non‐infected patients were considered eligible. primary outcomes triglyceride, LDL‐C, HDL‐C, total cholesterol levels, which examined using random‐effects model R software version 4.4. Results There 17 studies more than 150,000 participants from 681 screened publications. Higher levels LDL (MD: 5.32 mg/dL; 95% CI: 1.315 9.319) 6.28 0.718 11.842), well lower HDL −2.06 −3.212 −0.915), results meta‐analysis. Among those infected, triglyceride likewise higher 7.93 0.413 15.436), but odds ratio (OR) did not show significant increase risk (OR: 1.002; 0.995 1.010). Conclusion infection associated dyslipidemia, suggesting potential link chronic bacterial metabolism. findings emphasize need for further research explore mechanisms therapeutic interventions.

Language: Английский

Clinical significance of serum Helicobacter pylori antibody cytotoxin-associated gene A levels in patients with unstable angina

European journal of medical research, Journal Year: 2024, Volume and Issue: 29(1)

Published: Dec. 18, 2024

We investigated the clinical significance of serum Helicobacter pylori cytotoxin-associated gene A (CagA) antibody levels in 768 patients with unstable angina (UA). Serum CagA were measured using ELISA. Demographic data, biomarkers, and SYNTAX scores collected. Patients followed up for 1 year major adverse cardiac events (MACE). CagA-positive UA had higher total cholesterol hsCRP levels, scores. correlated positively TC, hsCRP, Kaplan–Meier analysis showed shorter MACE-free survival patients. predicted MACE occurrence within year, along H. positivity is associated worse prognosis correlate lipid metabolism inflammatory markers.

Language: Английский