Chlamydia trachomatis: From Urogenital Infections to the Pathway of Infertility

Genes, Journal Year: 2025, Volume and Issue: 16(2), P. 205 - 205

Published: Feb. 7, 2025

Chlamydia trachomatis (CT) is a major cause of sexually transmitted infections (STIs) worldwide, with significant implications for reproductive health. The bacterium's genome contains highly polymorphic regions, influencing both the type and severity infections. These genetic variations, particularly those occurring in outer membrane protein (MOMP) gene, are critical classifying bacterium into distinct serovars enable CT to adapt diverse host environments, contributing its immune evasion, persistence, pathogenicity. Persistent or untreated urogenital can lead chronic inflammation, tissue damage, pelvic inflammatory disease, ultimately increasing risk ectopic pregnancy, spontaneous abortion, infertility. This review consolidates current knowledge on diversity CT, potential role modulating infection outcomes, evasion mechanisms. By integrating scientific evidence linking chlamydial infertility, we underscore urgent need targeted research address this public health challenge.

Language: Английский

Chlamydia trachomatis regulates ferroptosis through the p53/SLC7A11 pathway to promote reproduction

Microbes and Infection, Journal Year: 2025, Volume and Issue: unknown, P. 105505 - 105505

Published: April 1, 2025

Language: Английский

Current Progress in the Development of mRNA Vaccines Against Bacterial Infections

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(23), P. 13139 - 13139

Published: Dec. 6, 2024

Bacterial infections have accompanied humanity for centuries. The discovery of the first antibiotics and subsequent golden era their temporarily shifted balance in this confrontation to side humans. Nevertheless, excessive improper use antibacterial drugs evolution bacteria has gotten better humans again. Therefore, today, search new or development alternative approaches prevention treatment bacterial is relevant topical Vaccination one most effective strategies infections. success new-generation vaccines, such as mRNA fight against viral prompted many researchers design vaccines biology interactions with host's immunity are much more complex compared viruses. In review, we discuss structural features key mechanisms evasion an immune response nine species pathogens which been developed tested animals. We focus on results experiments involving application various animal models possible options improving vaccines' effectiveness. This comprehensive reviews vivo improve our knowledge.

Language: Английский