Integrated metabolomics and intestinal microbiota analysis to reveal anti-post-weaning diarrhea mechanisms of Modified Yupingfeng Granule in Rex rabbits DOI Creative Commons
Dongbo Li, Chao Li,

Ning Liu

et al.

Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 16

Published: April 10, 2025

Post-weaning Diarrhea (PWD) is a kind of physiological stress diarrhea in Rex rabbits after weaning, which can lead to death severe cases. Traditional Chinese medicine (TCM) has been widely used animal due its advantages natural origin, diverse functions, safety, reliability, economy and environmental protection. Modified Yupingfeng Granule (MYPFG) an improved prescription based on the famous traditional (YPF), combined with other TCM obvious synergistic additive activity order obtain excellent for PWD. In this study, 120 weaned were randomly allocated 4 treatment groups, including control (CON), low dose (LD), medium (MD), high (HD). Rabbits fed diet or different MYPFG proportions 30 days. The study 16S rRNA analysis intestinal microbiota cecal contents metabolomics explore effect rabbits. increased average daily gain, villus length crypt depth ratio decreased feed meat ratio, frequency, mortality rate, (p < 0.05). test found that could change abundances Patescibacteria, Sphingobium, Ruminococcus, Oxalobacter. Metabolomics may be related regulation Glycine, serine threonine metabolism, Arginine proline metabolism. Nicotinate nicotinamide regulate metabolic pathway some amino acids alleviate PWD

Language: Английский

Integrated metabolomics and intestinal microbiota analysis to reveal anti-post-weaning diarrhea mechanisms of Modified Yupingfeng Granule in Rex rabbits DOI Creative Commons
Dongbo Li, Chao Li,

Ning Liu

et al.

Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 16

Published: April 10, 2025

Post-weaning Diarrhea (PWD) is a kind of physiological stress diarrhea in Rex rabbits after weaning, which can lead to death severe cases. Traditional Chinese medicine (TCM) has been widely used animal due its advantages natural origin, diverse functions, safety, reliability, economy and environmental protection. Modified Yupingfeng Granule (MYPFG) an improved prescription based on the famous traditional (YPF), combined with other TCM obvious synergistic additive activity order obtain excellent for PWD. In this study, 120 weaned were randomly allocated 4 treatment groups, including control (CON), low dose (LD), medium (MD), high (HD). Rabbits fed diet or different MYPFG proportions 30 days. The study 16S rRNA analysis intestinal microbiota cecal contents metabolomics explore effect rabbits. increased average daily gain, villus length crypt depth ratio decreased feed meat ratio, frequency, mortality rate, (p < 0.05). test found that could change abundances Patescibacteria, Sphingobium, Ruminococcus, Oxalobacter. Metabolomics may be related regulation Glycine, serine threonine metabolism, Arginine proline metabolism. Nicotinate nicotinamide regulate metabolic pathway some amino acids alleviate PWD

Language: Английский

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