Is colloidal oat an effective emollient ingredient for the prevention and treatment of atopic dermatitis in infants? DOI Creative Commons

Joseph F. Fowler,

Lin Ma,

James N. Bergman

et al.

Journal of Dermatological Treatment, Journal Year: 2025, Volume and Issue: 36(1)

Published: April 21, 2025

Atopic dermatitis (AD) is a chronic inflammatory skin condition characterized by barrier dysfunction and immune dysregulation, often leading to increased allergen penetration, sensitization, secondary infections. Colloidal oat emollients are widely used in adult AD management, but their role pediatric treatment, prevention, allergy modulation remains under investigation. A comprehensive literature review evaluated clinical preclinical studies on colloidal oat-containing treatment prevention. Studies assessing function, modulation, food risk, healthcare utilization were included. improved hydration, reduced transepidermal water loss (TEWL), supported repair, fewer flares reliance steroid treatments. suggest that early, consistent use of advanced emollient formulations may lower incidence high-risk infants reduce sensitization rates. Real-world data indicate patients using have clinic visits overall costs. Concerns about remain unsubstantiated most studies. effective, well-tolerated, cost-efficient for management. Their barrier-restorative anti-inflammatory properties risk. Future research should focus head-to-head comparisons optimize strategies.

Language: Английский

Subcutaneous Injection and Brush Application of Ovalbumin–Aluminum Salt Solution Induces Dermatitis-like Changes in Mice DOI Open Access
Gabriel Siquier-Dameto, Ainhoa Iguaran-Pérez,

Javier Gimeno-Beltrán

et al.

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(5), P. 1701 - 1701

Published: March 3, 2025

Background: Intraperitoneal sensitization combined with topical and/or epicutaneous treatment using an ovalbumin (OVA)–aluminum salt solution (OVA-AL) represents a model for inducing atopic dermatitis (AD). However, the combination of subcutaneous and cutaneous application OVA-AL via brush has not been explored as method AD. Methods: Adult mice were subcutaneously injected following on days 0, 7, 14 treated to dorsal skin fortnightly until 35 49. Concomitant alloknesis changes assessed. Mice Balb/c ICR-CD1 strains day 35, only strain continuing Control animals received saline. At 49 days, was harvested processed histological analysis. Results: developed dry skin, no scratching or alloknesis. Histological examination revealed increase in mast cells collagen deposition. Conclusions: Dermatitis-like symptoms observed this administration method.

Language: Английский

Citations

0
Is colloidal oat an effective emollient ingredient for the prevention and treatment of atopic dermatitis in infants? DOI Creative Commons

Joseph F. Fowler,

Lin Ma,

James N. Bergman

et al.

Journal of Dermatological Treatment, Journal Year: 2025, Volume and Issue: 36(1)

Published: April 21, 2025

Atopic dermatitis (AD) is a chronic inflammatory skin condition characterized by barrier dysfunction and immune dysregulation, often leading to increased allergen penetration, sensitization, secondary infections. Colloidal oat emollients are widely used in adult AD management, but their role pediatric treatment, prevention, allergy modulation remains under investigation. A comprehensive literature review evaluated clinical preclinical studies on colloidal oat-containing treatment prevention. Studies assessing function, modulation, food risk, healthcare utilization were included. improved hydration, reduced transepidermal water loss (TEWL), supported repair, fewer flares reliance steroid treatments. suggest that early, consistent use of advanced emollient formulations may lower incidence high-risk infants reduce sensitization rates. Real-world data indicate patients using have clinic visits overall costs. Concerns about remain unsubstantiated most studies. effective, well-tolerated, cost-efficient for management. Their barrier-restorative anti-inflammatory properties risk. Future research should focus head-to-head comparisons optimize strategies.

Language: Английский

Citations

0