Journal of the American Heart Association,
Journal Year:
2022,
Volume and Issue:
11(6)
Published: March 2, 2022
Background
MAT9001
is
an
omega-3
free
fatty
acid
(FFA)
formulation
containing
mainly
eicosapentaenoic
(EPA)
and
docosapentaenoic
(DPA).
Compared
with
icosapent
ethyl
(EPA-ethyl
esters
[EE]),
EPA+DPA-FFA
previously
showed
enhanced
triglyceride
lowering
higher
plasma
EPA
when
both
were
administered
once
daily
a
very-low
fat
diet.
This
trial
compared
pharmacodynamic
responses
levels
following
twice
dosing,
meals,
of
EPA-EE
in
hypertriglyceridemic
subjects
consuming
Therapeutic
Lifestyle
Changes
Methods
Results
open-label,
randomized,
2-way
crossover
trial,
28-day
treatment
periods
separated
by
≥28-day
washout,
was
conducted
at
8
US
centers
included
100
fasting
triglycerides
1.70
to
5.64
mmol/L
(150-499
mg/dL)
(median
2.31
[204
mg/dL];
57%
women,
average
age
60.3
years).
The
primary
end
point
least
squares
geometric
mean
percent
change
from
baseline
triglycerides.
In
the
94
analyzable
data
for
periods,
reduced
baseline:
20.9%
18.3%,
respectively
(P=not
significant).
high-sensitivity
C-reactive
protein
5.8%;
increased
8.5%
(P=0.034).
EPA,
DPA,
total
(EPA+docosahexaenoic
acid+DPA)
concentrations
848%,
177%,
205%,
respectively,
corresponding
changes
692%,
140%,
165%
(all
P<0.001).
docosahexaenoic
1.7%;
decreased
3.3%
(P=0.011).
Lipoprotein
cholesterol
apolipoprotein
did
not
differ
between
treatments.
Conclusions
raised
significantly
more
than
EPA-EE.
also
without
increasing
low-density
lipoprotein
cholesterol.
Registration
URL:
https://www.clinicaltrials.gov;
Unique
identifier:
NCT04177680.
Nutrients,
Journal Year:
2023,
Volume and Issue:
15(7), P. 1748 - 1748
Published: April 3, 2023
A
great
number
of
chemically
diverse
pancreatic
lipase
(PL)
inhibitors
have
been
identified
to
tackle
obesity;
however,
very
few
them
entered
clinical
studies.
The
ethanolic
extract
sesame
meal
is
a
potent
PL
inhibitor,
and
its
activity
hinges
exclusively
on
two
free
fatty
acids:
linoleic
acid
oleic
acid,
which
were
proven
reduce
postprandial
triglyceride
excursion
in
rats.
Herein,
investigate
the
efficacy
extract,
crossover
trial,
30
healthy
volunteers
randomized
receive
containing
experimental
food
or
placebo
along
with
high-fat
meal.
Treatment
significantly
lowered
incremental
serum
concentration
reduced
area
under
curve
(iAUC)
by
16.8%
(p-value
=
0.03)
compared
placebo.
Significant
decreases
remnant-like
lipoprotein
particle
cholesterol
low-density
particles
also
observed,
whereas
high-density
was
increased.
These
results
suggest
that
treatment
triglycerides
improved
lipidemic
profile
after
high
dietary
fat
intake
individuals,
indicating
substantial
potential
natural
products
rich
these
compounds
for
management
obesity
related
conditions.
