Indian Heart Journal,
Journal Year:
2023,
Volume and Issue:
76(2), P. 94 - 100
Published: Dec. 7, 2023
The
purpose
of
this
narrative
review
is
to
provide
a
comprehensive
overview
current
research
on
heart-gut
cross
talk
and
its
implications
for
cardiovascular
disease.
To
uncover
relevant
preclinical
clinical
examining
talk,
thorough
literature
search
was
undertaken
utilising
electronic
databases.
chosen
publications
were
critically
examined,
major
findings
synthesised
offer
perspective
the
subject.
We
want
synthesise
most
recent
study
findings,
explain
underlying
mechanisms,
potential
treatment
techniques.
By
exploring
bidirectional
connection
between
heart
gut,
we
shed
light
novel
future
options
prevention
diseases.
an
exciting
field
with
Understanding
complex
gastrointestinal
tract
may
lead
development
therapeutic
targets
therapies
management
Future
should
concentrate
identifying
specific
processes
driving
crosstalk
as
well
assessing
efficacy
targeting
gut
microbiota
gut-brain
axis
in
improving
outcomes.
Communications Biology,
Journal Year:
2025,
Volume and Issue:
8(1)
Published: Jan. 16, 2025
As
global
temperatures
rise,
heat-related
chronic
health
disorders
are
predicted
to
become
more
prevalent.
We
tested
whether
a
single
exposure
acute
heat
illness,
using
preclinical
mouse
model
of
exertional
stroke
(EHS),
can
induce
late-emerging
that
progress
into
disease.
Following
EHS,
mice
were
followed
for
3
months;
after
two
weeks
recovery,
half
placed
on
Western
diet
determine
if
previous
EHS
amplifies
the
negative
consequences
an
atherogenic
diet.
When
compared
sham
exercise
controls,
EHS-exposed
exhibit
accelerated
diet-induced
obesity,
develop
low
level
cardiac
hypertrophy,
liver
steatosis,
severe
hypoproteinemia
and
loss
metabolic
flexibility
in
myocardium.
The
latter
is
characterized
by
shift
towards
predominant
glucose
metabolism
glycolysis.
These
results
demonstrate
illness
long-lasting
unexpected
mammals
increased
vulnerability
secondary
stressors.
Life Sciences,
Journal Year:
2025,
Volume and Issue:
363, P. 123407 - 123407
Published: Jan. 17, 2025
Butyrate,
a
short-chain
fatty
acid,
has
shown
potential
to
improve
left
ventricular
(LV)
function
and
induce
vasorelaxation
in
rodents.
Butyrate
may
either
be
produced
by
the
microbiome
colon,
ingested
or
administered
intravenously.
This
study
aimed
evaluate
effects
of
butyrate
on
cardiac
output
(CO)
associated
hemodynamic
variables
porcine
model.
In
randomized,
blinded
crossover
study,
ten
healthy
60-kg
pigs
were
given
three
hour
infusions
600
mM
equimolar
sodium
chloride
(control).
CO
was
measured
thermodilution
via
pulmonary
artery
catheter.
LV
contractility
assessed
using
pressure-volume
admittance
catheterization.
Additionally,
isolated
coronary
arteries
exposed
wire
myograph
vasorelaxation.
infusion
increased
plasma
concentration
0.53
(95
%
confidence
interval
(CI):
0.49
0.58
mM,
P
<
0.001)
1.6
L/min
CI:
1.0
2.1
L/min,
compared
with
control.
Heart
rate,
ejection
fraction,
efficiency
dP/dtmax
rose,
while
systemic
vascular
resistance,
arterial
elastance,
mean
pressure
end-systolic
volume
decreased.
Loadindependent
stroke
did
not
significantly
differ.
myograph,
relaxed
response
concentration-dependent
manner.
increases
lowers
resistance
large
animal
model,
through
HR
Load-independent
altered.
We
observed
indices
end-organ
perfusion.
These
potentially
beneficial
cardiovascular
properties
should
further
studied.
Journal of Cardiovascular Development and Disease,
Journal Year:
2025,
Volume and Issue:
12(2), P. 42 - 42
Published: Jan. 25, 2025
Mitochondria
play
a
crucial
role
in
multiple
cellular
processes
such
as
energy
metabolism,
generation
of
reactive
oxygen
species,
excitation-contraction
coupling,
cell
survival
and
death.
Dysfunction
mitochondria
contributes
to
the
development
cancer;
neuromuscular,
cardiovascular/congenital
heart
disease;
metabolic
diseases,
including
diabetes.
Mitochondrial
dysfunction
can
result
excessive
decrease
production,
mitophagy
apoptosis.
All
these
are
known
be
dysregulated
cardiovascular
diseases.
The
focus
this
review
is
summarize
our
current
knowledge
mitochondrial
dysfunction,
apoptosis,
pediatric
congenital
disease
due
maternal
diabetes
or
structural
cardiac
defects,
with
on
single-ventricle
disease.
We
also
discuss
recent
mitochondria-targeted
therapies
for
Biomedicines,
Journal Year:
2025,
Volume and Issue:
13(2), P. 343 - 343
Published: Feb. 3, 2025
Short-chain
fatty
acids
(SCFAs),
produced
through
fermentation
of
dietary
fibers
by
gut
bacteria,
play
a
central
role
in
modulating
cardiovascular
function
and
heart
failure
(HF)
development.
The
progression
HF
is
influenced
intestinal
barrier
dysfunction
microbial
translocation,
where
SCFAs
serve
as
key
mediators
the
gut–heart
axis.
This
review
examines
complex
metabolic
interactions
between
other
microbiota
metabolites
HF,
including
their
relationships
with
trimethylamine
N-oxide
(TMAO),
aromatic
amino
(AAAs),
B
vitamins,
bile
(BAs).
We
analyze
associations
SCFA
production
clinical
parameters
such
left
ventricular
ejection
fraction
(LVEF),
N-terminal
pro-B-type
natriuretic
peptide
(NT-proBNP),
glomerular
filtration
rate
(GFR).
Gaining
insights
into
networks
offers
new
potential
therapeutic
targets
prognostic
markers
for
managing
failure,
although
significance
needs
further
exploration.
Cellular and Molecular Life Sciences,
Journal Year:
2025,
Volume and Issue:
82(1)
Published: April 2, 2025
Propionic
acidemia
is
an
inborn
error
of
metabolism
caused
by
mutations
in
either
the
PCCA
or
PCCB
genes.
Patients
with
propionic
experience
a
range
complications,
including
life-threatening
cardiac
dysfunctions.
However,
pathological
mechanisms
underlying
acidemia-associated
diseases
remain
largely
unknown.
To
gain
insights
into
metabolic
alterations
acidemia,
we
studied
human
induced
pluripotent
stem
cell-derived
cardiomyocytes
generated
from
patient
two
pathogenic
(p.Cys616_Val633del
and
p.Gly477Glufs9*)
healthy
individual.
Using
stable
isotope-based
flux
analysis,
confirmed
that
lead
to
impaired
propionyl-CoA
carboxylase
activity
cardiomyocytes.
In
addition
being
converted
propionylcarnitine,
accumulated
can
also
be
hydrolyzed
propionate
exported
out
cell,
serving
as
secondary
"pressure
valve"
regulate
cellular
levels.
Interestingly,
deficiency
was
found
shift
fuel
fatty
acid
oxidation
increased
glucose
patients
acidemia.
This
switch
less
energy-efficient
may
contribute
development
chronic
dysfunction
Biomedicines,
Journal Year:
2025,
Volume and Issue:
13(4), P. 911 - 911
Published: April 9, 2025
Heart
failure
(HF)
has
become
an
immense
health
concern
affecting
almost
1–2%
of
the
population
globally.
It
is
a
complex
syndrome
characterized
by
activation
sympathetic
nervous
system
and
Renin–Angiotensin–Aldosterone
(RAAS)
axis
as
well
endothelial
dysfunction,
oxidative
stress,
inflammation.
The
recent
literature
points
towards
interaction
between
intestinal
flora
heart,
also
called
gut–heart
axis.
human
gastrointestinal
tract
naturally
inhabited
various
microbes,
which
are
distinct
for
each
patient,
regulating
functions
many
organs.
Alterations
gut
microbiome,
process
dysbiosis,
may
result
in
systemic
diseases
have
been
associated
with
heart
through
inflammatory
autoimmune
mechanisms.
disorder
permeability
favors
translocation
microbes
metabolites
capable
inducing
inflammation,
thus
further
contributing
to
deterioration
normal
cardiac
function.
Besides
diet
modifications
exercise
training,
studies
revealed
possible
microbiota
targeted
treatments
managing
failure.
aim
this
review
demonstrate
impact
environment
induced
microbiome
its
on
elucidation
these
novel
therapeutic
approaches.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(9), P. 4264 - 4264
Published: April 30, 2025
Cardiovascular
diseases
(CVDs),
including
heart
failure
(HF),
hypertension,
myocardial
infarction
(MI),
and
atherosclerosis,
are
increasingly
linked
to
gut
microbiota
dysbiosis
its
metabolic
byproducts.
HF,
affecting
over
64
million
individuals
globally,
is
associated
with
systemic
inflammation
barrier
dysfunction,
exacerbating
disease
progression.
Similarly,
hypertension
MI
correlate
reduced
microbial
diversity
an
abundance
of
pro-inflammatory
bacteria,
contributing
vascular
increased
cardiovascular
risk.
Atherosclerosis
also
influenced
by
dysbiosis,
key
metabolites
such
as
trimethylamine-N-oxide
(TMAO)
short-chain
fatty
acids
(SCFAs)
playing
crucial
roles
in
pathogenesis.
Emerging
evidence
highlights
the
therapeutic
potential
natural
compounds,
flavonoids,
omega-3
acids,
resveratrol,
curcumin,
marine-derived
bioactives,
which
modulate
confer
cardioprotective
effects.
These
insights
underscore
a
critical
regulator
health,
suggesting
that
targeting
may
offer
novel
preventive
strategies.
Further
research
needed
elucidate
underlying
mechanisms
optimize
microbiome-based
interventions
for
improved
outcomes.
