Computational Biology in the Discovery of Biomarkers in the Diagnosis, Treatment and Management of Cardiovascular Diseases

Cardiology and Cardiovascular Medicine, Journal Year: 2024, Volume and Issue: 8(5)

Published: Jan. 1, 2024

Cardiovascular diseases are the leading cause of mortality worldwide, with a disproportionately high burden in low- and middle-income countries. Biomarkers play crucial role early detection, diagnosis, treatment cardiovascular by providing valuable insights into normal abnormal conditions heart vascular system. The biomarkers derived from cells tissues can be identified quantified blood other body fluids tissues. Changes their expression level under pathological condition provide clinical information on underlying pathophysiology that could have predictive, diagnostic, prognostic value disease process, therefore incorporated guidelines. This enhances effectiveness risk stratification therapeutic decisions personalized medicine improvement patient outcomes. protein, carbohydrate, or genome-based may also lipids nucleic acids. Computational biology has emerged as powerful discipline biomarker discovery, leveraging computational techniques to identify validate biological markers for prognosis, drug response prediction. convergence advanced technologies, such artificial intelligence, multi-omics profiling, liquid biopsies, imaging, led significant shift discovery development biomarkers, enabling integration data multiple scales more comprehensive understanding complex signaling transcriptional networks pathogenesis. In this article, we reviewed integrated genomics, proteomics, metabolomics, together machine learning predictive modeling diseases. We discussed specific including epigenetic, metabolic, emerging extracellular vesicles, miRNAs, circular RNAs,

Language: Английский

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CVD Atlas: a multi-omics database of cardiovascular disease

Nucleic Acids Research, Journal Year: 2024, Volume and Issue: 53(D1), P. D1348 - D1355

Published: Oct. 1, 2024

Cardiovascular disease (CVD) is the leading cause of illness and death worldwide. Numerous studies have been conducted into underlying mechanisms molecular characteristics CVD using various omics approaches. However, there still a need for comprehensive resources on CVD. To fill this gap, we present Atlas, accessed at https://ngdc.cncb.ac.cn/cvd. This database compiles knowledge information from manual curation, large-scale data analysis, existing databases, utilizing multi-omics to understand CVDs comprehensively. The current version Atlas contains 215,333 associations gathered 308 publications, 652 datasets 7 databases. It covers 190 diseases 44 traits across multiple levels. Additionally, it provides an interactive graph that integrates disease-gene two types analysis tools, offering engaging way query display relationships. also features user-friendly web interface allows users easily browse, search, download all association information, research metadata, annotation details. In conclusion, valuable resource enhances accessibility utility related CVD, benefiting human health communities.

Language: Английский

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Targeting Intrinsically Disordered Proteins (IDPs) in Drug Discovery

Published: Nov. 29, 2024

"Revolutionizing Drug Delivery Through Computational Design: Nanotechnology and Personalized Therapeutics" explores the transformative potential of computational methodologies in advancing drug delivery systems. This chapter delves into intersection nanotechnology personalized medicine, highlighting how design techniques have revolutionized development targeted efficient drug-delivery vehicles. integration advanced algorithms modeling approaches, researchers can optimize formulations, enhance efficiency, tailor treatments to individual patient profiles. Key topics include role artificial intelligence, nanomaterials, real-time monitoring shaping future delivery. Furthermore, emphasizes importance interdisciplinary collaboration driving innovation overcoming challenges this rapidly evolving field. The promise therapeutics improving outcomes is underscored, with a focus on precision medicine approaches. Overall, provides insights current state research outlines directions for harnessing address unmet medical needs.

Language: Английский

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A retrospective case-control study for Clinical Validation of mutated ZNF208 as a novel biomarker of fatal blast crisis in Chronic Myeloid Leukemia

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: March 15, 2024

Abstract The hallmark of Chronic Myeloid Leukemia (CML) is Philadelphia chromosome t(9:22), which leads to formation BCR-ABL1 fusion oncogene. induces genetic instability, causing the progression chronic myeloid leukemia from manageable Phase (CP-CML) accelerated phase (AP-CML) and ultimately lethal blast crisis (BC-CML). precise mechanism responsible for CML are not well comprehended, there a lack specific molecular biomarkers advanced CML. Mutations in transcription factors (TFs) have significant role cancer initiation, relapses, invasion, metastasis, resistance anti-cancer drugs. Recently, our group reported association novel factor, ZNF208, with was dire need clinical validation this biomarker. Therefore, aim study clinically validate mutated ZNF208 as biomarker larger cohort AP- BC-CML patients using control-case studies. A total 73 (N=73) King Saud University Medical City Riyadh Abdulaziz National Guard Hospital, Al-Ahsa, Saudi Arabia were enrolled (2020-2023), experimental (cases) consisting AP-CML (n=20) (n=12). controls consisted age/sex matched CP-CML (n=41). approved by Research Ethics Committees participating institutes all provided informed consent study. Clinical evaluations conducted according guidelines established European LeukemiaNet 2020. Targeted resequencing ZNF 208 employed Illumina NextSeq500 instrument (Illumina, San Diego, CA, USA) mutations confirmed Sanger sequencing. Both next generation sequencing identified missense mutation (c.64G>A) ZNF208. 56 (93.3) and12 (100) CP-, respectively, while none (0%) or healthy genomic databases (p=0.0001). studies show that very AP-and patients. other such proteins may cause carcinogenesis interacting KAP-1 repressor silence many target genes thus prove be drug targets well. we recommend carrying out prospective trials further its utilization decision, investigating pathogenesis investigate potential Simple Summary type blood caused oncogene, leading instability changes. This results advancement (CP) an (AP) finally (BC). development known, dearth dependable shared indicators. Transcription class molecules that, when altered, significantly contribute cancer, including has been factor gene associated BC-CML. Here, carried targeted resequencing. detected 0 (0%), respectively (p=0.0001) demonstrating high specificity shows progression. We

Language: Английский

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Multi-Omic Reveal that Gamabufotalin Exerts an Anti-Hepatocellular Carcinoma Effect by Regulation of Amino Acid Metabolism Via Targeting Stambpl1

Published: Jan. 1, 2024

Language: Английский

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Diagnose des akuten Koronarsyndroms

Angewandte Nuklearmedizin, Journal Year: 2024, Volume and Issue: 47(03), P. 192 - 199

Published: Sept. 1, 2024

Zusammenfassung Das akute Koronarsyndrom ist in vielen Fällen die erste klinische Manifestation der zugrunde liegenden Atherosklerose und stellt häufig eine Notfallsituation dar. In kurzer Zeit müssen Ursache ggf. mögliche Differenzialdiagnosen erkannt zügig gehandelt werden. Die richtige Interpretation von Anzeichen Symptomen entsprechende Auswahl diagnostischen Methode sind Basis für weitere Therapie.

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Delivery of liquid metal particles and tanshinone IIA into the pericardial cavity for myocardial infarction treatment

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

The SA/LM/TA, prepared by liquid metal (LM) and Tanshinone IIA (TA) drugs dispersed into sodium alginate (SA) solution ultrasonication, can be used for myocardial infarction treatment.

Language: Английский

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Multicellular 3D models to study myocardial ischemia–reperfusion injury

Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12

Published: Nov. 15, 2024

Coronary heart disease is a major global health threat, with acute myocardial ischemia–reperfusion injury (IRI) being contributor to damage following an ischemic event. IRI occurs when blood flow tissues restored and exacerbates the cellular caused by ischemia/hypoxia. Although animal studies investigating have provided valuable insights, their translation into clinical outcomes has been limited, medical practice remains cumbersome. Recent advancements in engineered three-dimensional human vitro models could offer promising avenue bridge “therapeutic valley of death” from bench bedside, enhancing understanding pathology. This review summarizes current state-of-the-art cardiovascular 3D models, including spheroids, organoids, cardiac microtissues, organ-on-a-chip systems. We provide overview advantages limitations context IRI, particular emphasis on crucial roles cell–cell communication multi-omics approaches enhance our pathophysiological processes involved its treatment. Finally, we discuss currently available multicellular IRI.

Language: Английский

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Artificial Bee Colony Algorithm in Multi-omics Analysis: A Case Study

Springer tracts in nature-inspired computing, Journal Year: 2024, Volume and Issue: unknown, P. 183 - 199

Published: Jan. 1, 2024

Language: Английский

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Multi-Omics Research on Angina Pectoris: A Novel Perspective

Aging and Disease, Journal Year: 2024, Volume and Issue: unknown, P. 0 - 0

Published: Jan. 1, 2024

Angina pectoris (AP), a clinical syndrome characterized by paroxysmal chest pain, is caused insufficient blood supply to the coronary arteries and sudden temporary myocardial ischemia hypoxia. Long-term AP typically induces other cardiovascular events, including infarction heart failure, posing serious threat patient safety. However, AP's complex pathological mechanisms developmental processes introduce significant challenges in rapid diagnosis accurate treatment of its different subtypes, stable angina (SAP), unstable (UAP), variant (VAP). Omics research has contributed significantly revealing various diseases with development high-throughput sequencing approaches. The application multi-omics approaches effectively interprets systematic information on from perspective genes, RNAs, proteins, metabolites. Integrating introduces novel avenues for identifying biomarkers distinguish subtypes. This study reviewed articles related elaborate progress (including genomics, transcriptomics, proteomics, metabolomics), summarized their applications screening employed discriminate multiple delineated integration methods Finally, we discussed advantages disadvantages applying single-omics approach distinguishing diverse Our review demonstrated that technologies preferable quick precise three types, namely SAP, UAP, VAP.

Language: Английский

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