Rice Husk Derived Activated Carbon‐Catalyzed Synthesis of Coumarin Derivatives: Study of Anti‐Cancer Activity DOI
Geetika Patel, Ashok R. Patel, Namrata Kahar

et al.

ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(37)

Published: Sept. 26, 2024

Abstract Herein, we report the fabrication of biomass rice husk‐derived chemically activated carbon (RCAC) sheets which are self‐assembled to 2D hollow porous materials and demonstrated their catalytic efficiency in domino Knoevenagel−Michael addition reaction for synthesis various bio‐active coumarin derivatives excellent yields under metal‐free conditions mild conditions. Particularly, have illustrated a facile, eco‐friendly, economical, sustainable method bis‐(4‐hydroxycoumarin)methanes, bis‐dimedones, 4‐hydroxy‐3‐thiomethylcoumarins, via three‐component reactions 4‐hydroxy coumarin/demedone, aldehydes or thiophenols. Moreover, Michael chalcone leading warfarin has also been using RCAC as catalyst. The cytotoxicity potential performed against human liver cancer cell line Hep‐G2 cells all synthesized products by 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyl tetrazolium bromide (MTT) method. study results indicates that compounds capable killing line. most potent anti‐proliferative activity was observed 3 g , 5 b c 9 cells.

Language: Английский

Peripheral Artery Disease: Molecular Mechanisms and Novel Therapies DOI
Anand Athavale, Eri Fukaya, Nicholas J. Leeper

et al.

Arteriosclerosis Thrombosis and Vascular Biology, Journal Year: 2024, Volume and Issue: 44(6), P. 1165 - 1170

Published: May 22, 2024

Language: Английский

Citations

7
Percutaneous Left Atrial Appendage Closure: Supporting Evidence, Limitations and Future Directions DOI Open Access

G. Imperatore,

Stijn Lochy,

Mohamed Ben Yedder

et al.

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(7), P. 2300 - 2300

Published: March 27, 2025

Percutaneous Left Atrial Appendage Occlusion (LAAO) has emerged as a promising intervention for stroke prevention in patients with atrial fibrillation who are contraindicated long-term anticoagulation therapy. Despite its growing adoption, comprehensive review of the LAAO procedure is essential to consolidate supporting evidence, identify limitations, and outline future directions. This aims evaluate efficacy safety LAAO, drawing on clinical trials real-world studies provide balanced perspective. Additionally, we address limitations current research, including variability patient selection, procedural techniques, follow-up protocols. By highlighting gaps knowledge areas improvement, this guide research efforts optimize expand therapeutic potential LAAO.

Language: Английский

Citations

0
Unraveling the Paradox: Can Anticoagulation Improve Outcomes in Patients With Heart Failure and Increased Bleeding Risk? DOI Open Access

Danish Saeed,

Daniel Fuenmayor,

Jose A Niño Medina

et al.

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: April 3, 2024

Heart failure (HF) patients frequently present with comorbidities such as atrial fibrillation (AF) or other cardiovascular conditions, elevating their risk of thromboembolic events. Consequently, anticoagulation therapy is often considered for thromboprophylaxis, although its initiation in HF complicated by concomitant bleeding factors. This review explores the paradoxical relationship between HF, increased risk, and potential benefits anticoagulation. Through an examination existing evidence from clinical trials, observational studies, meta-analyses, we aim to elucidate role risk. Despite guidelines recommending certain AF factors, uncertainty persists regarding optimal management strategy those at heightened bleeding. The discusses pathophysiological mechanisms linking thrombosis, challenges assessment, strategies minimize while optimizing thromboprophylaxis. Shared decision-making clinicians emphasized essential individualized treatment plans that balance against complications. Furthermore, it examines emerging anticoagulant agents management, highlighting need further research delineate inform evidence-based practice. In conclusion, holds promise improving outcomes patients, careful consideration patient-specific factors ongoing efforts are optimize therapeutic this population.

Language: Английский

Citations

1
Early versus Later Anticoagulation in Post-Stroke patients with Atrial Fibrillation: A systematic review and Meta-analysis DOI Open Access
Carlos Zavaleta-Corvera, Gino Vasquez-Paredes,

Joaquín Sarmiento-Falen

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: April 22, 2024

ABSTRACT Background Atrial fibrillation (AF) is the most common cardiac arrhythmia and significantly increases risk of ischemic stroke, one its serious complications. The intricate relationship between AF stroke necessitates careful consideration in timing anticoagulant therapy initiation to prevent recurrence, hemorrhagic transformation, other Aim This study aims evaluate efficacy safety early versus late treatment patients with after an addressing critical gap optimal balance recurrent against bleeding risks. Methods A systematic review meta-analysis was conducted following PRISMA-2020 guidelines, searches performed across multiple databases including PubMed, Scopus, Web Science, EMBASE, Cochrane. Randomized controlled trials comparing later anticoagulation post-stroke were included. Data synthesis using a random-effects model, considering symptomatic intracerebral hemorrhage, mortality as primary outcomes. Results From 1444 identified records, three studies 2989 included, comprising diverse population terms geography demographics. Meta-analysis revealed that might be associated reduced (RR 0.72, 95% CI [0.51-1.00])(p=0.05), although statistical significance borderline. No significant differences found hemorrhage or rates initiation. Early intervention was, however, reduction adverse outcomes [0.54-0.96])(p=0.03). Conclusions post-ischemic may offer protective effect events no increase suggests can safely considered, particularly light reducing

Language: Английский

Citations

0
Rice Husk Derived Activated Carbon‐Catalyzed Synthesis of Coumarin Derivatives: Study of Anti‐Cancer Activity DOI
Geetika Patel, Ashok R. Patel, Namrata Kahar

et al.

ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(37)

Published: Sept. 26, 2024

Abstract Herein, we report the fabrication of biomass rice husk‐derived chemically activated carbon (RCAC) sheets which are self‐assembled to 2D hollow porous materials and demonstrated their catalytic efficiency in domino Knoevenagel−Michael addition reaction for synthesis various bio‐active coumarin derivatives excellent yields under metal‐free conditions mild conditions. Particularly, have illustrated a facile, eco‐friendly, economical, sustainable method bis‐(4‐hydroxycoumarin)methanes, bis‐dimedones, 4‐hydroxy‐3‐thiomethylcoumarins, via three‐component reactions 4‐hydroxy coumarin/demedone, aldehydes or thiophenols. Moreover, Michael chalcone leading warfarin has also been using RCAC as catalyst. The cytotoxicity potential performed against human liver cancer cell line Hep‐G2 cells all synthesized products by 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyl tetrazolium bromide (MTT) method. study results indicates that compounds capable killing line. most potent anti‐proliferative activity was observed 3 g , 5 b c 9 cells.

Language: Английский

Citations

0