Pore-Forming VDAC Proteins of the Outer Mitochondrial Membrane: Regulation and Pathophysiological Role (Review) DOI
Natalia V. Belosludtseva, Mikhail V. Dubinin, Konstantin N. Belosludtsev

et al.

Биохимия, Journal Year: 2024, Volume and Issue: 89(6), P. 1049 - 1069

Published: Dec. 25, 2024

Voltage-dependent anion channels of the outer membrane mitochondria are a family pore-forming β-barrel proteins (VDAC1-3), which carry out controlled “filtration” small molecules and ions between cytoplasm mitochondria. The possibility temporary conformational transitions closed open states VDAC proteins, as well their interaction with number cytoplasmic mitochondrial allows these not only to regulate permeability for major metabolites ions, but also participate in control vital intracellular processes pathological conditions. This work is devoted analysis novel data obtained on putative molecular structure, regulatory mechanisms, pathophysiological role possible future directions this area research.

Language: Английский

Pore-Forming VDAC Proteins of the Outer Mitochondrial Membrane: Regulation and Pathophysiological Role DOI
Natalia V. Belosludtseva, Mikhail V. Dubinin, Konstantin N. Belosludtsev

et al.

Biochemistry (Moscow), Journal Year: 2024, Volume and Issue: 89(6), P. 1061 - 1078

Published: June 1, 2024

Language: Английский

Citations

6
Mitochondria associated membranes in dilated cardiomyopathy: connecting pathogenesis and cellular dysfunction DOI Creative Commons
Pingge He, Hongbo Chang, Ying Qiu

et al.

Frontiers in Cardiovascular Medicine, Journal Year: 2025, Volume and Issue: 12

Published: March 17, 2025

Dilated cardiomyopathy (DCM) is a leading cause of heart failure, yet therapeutic options remain limited. While traditional research has focused on mechanisms such as energy deficits and calcium dysregulation, increasing evidence suggests that mitochondria-associated membranes (MAMs) could provide new insights into understanding treating DCM. In this narrative review, we summarize the key role MAMs, crucial endoplasmic reticulum (ER)-mitochondria interfaces, in regulating cellular processes homeostasis, lipid metabolism, mitochondrial dynamics. Disruption MAMs function may initiate pathological cascades, including ER stress, inflammation, cell death. These disruptions MAM lead to further destabilization homeostasis. Identifying modulators cardiac health novel for early diagnosis targeted therapies

Language: Английский

Citations

0
Endoplasmic Reticulum-Mitochondrial Encounter Structure regulates the mitochondrial morphology, DON biosynthesis and toxisome formation in Fusarium graminearum DOI

Song Ji-chang,

Yige Li, Ziyang Zhang

et al.

Microbiological Research, Journal Year: 2024, Volume and Issue: 289, P. 127892 - 127892

Published: Sept. 3, 2024

Language: Английский

Citations

1
Pore-Forming VDAC Proteins of the Outer Mitochondrial Membrane: Regulation and Pathophysiological Role (Review) DOI
Natalia V. Belosludtseva, Mikhail V. Dubinin, Konstantin N. Belosludtsev

et al.

Биохимия, Journal Year: 2024, Volume and Issue: 89(6), P. 1049 - 1069

Published: Dec. 25, 2024

Voltage-dependent anion channels of the outer membrane mitochondria are a family pore-forming β-barrel proteins (VDAC1-3), which carry out controlled “filtration” small molecules and ions between cytoplasm mitochondria. The possibility temporary conformational transitions closed open states VDAC proteins, as well their interaction with number cytoplasmic mitochondrial allows these not only to regulate permeability for major metabolites ions, but also participate in control vital intracellular processes pathological conditions. This work is devoted analysis novel data obtained on putative molecular structure, regulatory mechanisms, pathophysiological role possible future directions this area research.

Language: Английский

Citations

0