Novel insights into RNA polymerase II transcription regulation: transcription factors, phase separation, and their roles in cardiovascular diseases DOI
Mengmeng Liu, Rui Li,

Xin Yuan

et al.

Biochemistry and Cell Biology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 14, 2024

Transcription factors (TFs) are specialized proteins that bind DNA in a sequence-specific manner and modulate RNA polymerase II (Pol II) multiple steps of the transcription process. Phase separation is spontaneous or driven process can form membrane-less organelles called condensates. By creating different liquid phases at active sites, formation condensates reduce water content condensate lower dielectric constant biological systems, which turn alters structure function nucleic acids condensate. In Pol transcription, phase shortens time TFs to target sites promotes transcriptional bursting. engaged developing several diseases, such as cardiovascular disease, by regulating mediating occurrence separation. This review aims summarize advances molecular mechanisms regulation, particular effect The role regulation disease will be elucidated, providing potential therapeutic targets for management treatment disease.

Language: Английский

Novel insights into RNA polymerase II transcription regulation: transcription factors, phase separation, and their roles in cardiovascular diseases DOI
Mengmeng Liu, Rui Li,

Xin Yuan

et al.

Biochemistry and Cell Biology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 14, 2024

Transcription factors (TFs) are specialized proteins that bind DNA in a sequence-specific manner and modulate RNA polymerase II (Pol II) multiple steps of the transcription process. Phase separation is spontaneous or driven process can form membrane-less organelles called condensates. By creating different liquid phases at active sites, formation condensates reduce water content condensate lower dielectric constant biological systems, which turn alters structure function nucleic acids condensate. In Pol transcription, phase shortens time TFs to target sites promotes transcriptional bursting. engaged developing several diseases, such as cardiovascular disease, by regulating mediating occurrence separation. This review aims summarize advances molecular mechanisms regulation, particular effect The role regulation disease will be elucidated, providing potential therapeutic targets for management treatment disease.

Language: Английский

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