Atherosclerosis Plus,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 1, 2024
A
large
body
of
evidence
has
shown
that
modulation
the
nuclear
receptors
peroxisome
proliferator-activated
(PPARs),
liver
X
(LXRs),
proprotein
convertase
subtilisin/kexin
type
9
(PCSK9)
and
inflammatory
processes
by
natural
compounds
hypolipidemic
anti-atherosclerotic
effects.
These
beneficial
outcomes
are
certainly
related
to
crucial
function
these
targets
in
maintaining
cholesterol
homeostasis
regulating
systemic
inflammation.
Currently,
therapeutic
scenario
for
cardiovascular
diseases
(CVD)
offers
a
plethora
widely
validated
functional
pharmacological
treatments
improve
health
status
patients.
However,
patients
increasingly
sceptical
which
often
associated
with
moderate
severe
side
The
aim
our
review
is
provide
collection
most
recent
scientific
on
common
phytochemicals,
used
centuries
Mediterranean
diet
traditional
chinese
medicine
act
key
regulators
inflammation,
could
constitute
important
tools
CVD
management.
Cell Death Discovery,
Journal Year:
2025,
Volume and Issue:
11(1)
Published: March 17, 2025
Abstract
Glioblastoma
is
a
highly
malignant
tumor
of
the
central
nervous
system
with
high
mortality
rate.
The
mechanisms
driving
glioblastoma
onset
and
progression
are
complex,
posing
substantial
challenges
for
developing
precise
therapeutic
interventions
to
improve
patient
survival.
Over
century
ago,
discovery
Warburg
effect
underscored
importance
abnormal
glycolysis
in
tumors,
marking
pivotal
moment
cancer
research.
Subsequent
studies
have
identified
mitochondrial
energy
conversion
as
fundamental
driver
growth.
Recently,
lipid
metabolism
has
emerged
critical
factor
cell
survival,
providing
an
alternative
source.
Research
shown
that
reprogrammed
glioblastoma,
playing
vital
role
shaping
biological
behavior
cells.
In
this
review,
we
aim
elucidate
impact
on
tumorigenesis
explore
potential
targets.
Additionally,
provide
insights
into
regulatory
govern
metabolism,
emphasizing
roles
key
genes
regulators
involved
essential
metabolic
process.
Molecules,
Journal Year:
2025,
Volume and Issue:
30(7), P. 1626 - 1626
Published: April 5, 2025
Caigua
(Cyclanthera
pedata
(L.)
Schrad.)
is
a
traditional
herbal
remedy
traditionally
used
in
Latin
America
for
its
health
benefits
and
to
treat
metabolic
disorders,
including
diabetes.
Despite
interest
use,
the
phytochemical
properties
of
caigua’s
secondary
metabolites
are
poorly
known.
This
study
aimed
isolate
main
flavone
glycosides
from
leaves
caigua
landrace
cultivated
Camonica
Valley
(Italy)
using
flash
chromatography
evaluate
their
potential
activity
toward
peroxisome
proliferator-activated
receptors
(PPARs)
transient
receptor
(TRP)
ion
channels
through
luciferase
intracellular
calcium
assays.
We
found
that
species-specific
glycoside,
chrysin-6-C-fucopyranoside,
showed
potent
selective
PPARγ,
with
no
effects
on
other
PPAR
subtypes
or
TRP
channels.
These
findings
indicate
plant
could
offer
safer
alternative
conventional
PPARγ
agonists,
whose
use
as
antidiabetic
drugs
limited
by
severe
side
currently
restrict
clinical
agonists.
Journal of Nanobiotechnology,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: April 23, 2025
Atherosclerosis
is
a
complex
cardiovascular
disease
driven
by
multiple
factors,
including
aging,
inflammation,
oxidative
stress,
and
plaque
rupture.
The
progression
of
this
often
covert,
emphasizing
the
need
for
early
biomarkers
effective
intervention
measures.
In
recent
years,
advancements
in
therapeutic
strategies
have
highlighted
potential
targeting
specific
processes
atherosclerosis,
such
as
localization,
macrophage
activity,
key
enzymes.
Based
on
this,
review
discusses
role
targeted
drugs
treatment
atherosclerosis.
It
also
focuses
their
clinical
efficacy
anti-atherosclerosis
ability
to
provide
more
precise
approaches.
findings
underscore
that
future
research
can
concentrate
exploring
newer
drug
delivery
systems
further
refine
enhance
long-term
dynamic
management
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(16), P. 8979 - 8979
Published: Aug. 18, 2024
Chronic
low-grade
inflammation
(CLGI)
is
associated
with
obesity
and
one
of
its
pathogenetic
mechanisms.
Lipopolysaccharide
(LPS),
a
component
Gram-negative
bacterial
cell
walls,
the
principal
cause
CLGI.
Studies
have
found
that
capsaicin
significantly
reduces
relative
abundance
LPS-producing
bacteria.
In
present
study,
Pharmaceuticals,
Journal Year:
2024,
Volume and Issue:
17(11), P. 1451 - 1451
Published: Oct. 30, 2024
:
Mexican
people
use
Smilax
dominguensis
as
a
traditional
medicine
for
diabetes
control.
Some
reports
have
shown
an
anti-hyperglycemic
effect
in
animal
models.
In
the
current
research,
chemical
bio-guided
fractionation
vitro
and
silico
was
performed
to
identify
compounds
with
hypolipidemic
effects
through
PPARγ/α
dual
agonist
activity
because
they
regulate
genes
involved
energy
storage
burning,
such
GLUT4
FATP.
Frontiers in Cardiovascular Medicine,
Journal Year:
2024,
Volume and Issue:
11
Published: Oct. 23, 2024
Objective
In
this
study,
we
aimed
to
compare
the
levels
of
inflammatory
markers
(C-reactive
protein,
CRP;
procalcitonin,
PCT)
and
blood
lipids
(total
cholesterol,
TC;
triglyceride,
TG;
high-density
lipoprotein
HDL-C;
low-density
LDL-C)
between
patients
with
stable
angina
control
group,
explore
correlation
these
parameters
severity
prognosis
angina.
Methods
We
retrospectively
selected
113
128
group
from
medical
record
system,
compared
their
factors
lipids.
also
assessed
using
Canadian
Cardiovascular
Society
(CCS)
classification
followed
up
for
1
year
any
cardiovascular
events.
Results
found
that
had
significantly
higher
CRP,
TC,
TG,
LDL-C,
lower
HDL-C
than
group.
Moreover,
LDL-C
were
positively
correlated
angina,
while
was
negatively
correlated.
During
follow-up
period,
37
experienced
events,
they
those
who
did
not.
Conclusion
Our
study
suggests
inflammation
dyslipidemia
are
closely
related
can
be
used
as
indicators
Applied Sciences,
Journal Year:
2024,
Volume and Issue:
14(21), P. 9994 - 9994
Published: Nov. 1, 2024
Background:
Peroxisome-proliferator-activated
receptors
(PPARs)
constitute
nuclear
transcription
factors
controlling
gene
expression
associated
with
cell
growth
and
proliferation,
diverse
proteins,
lipids,
glucose
metabolism,
being
related
to
several
other
pathophysiological
states
such
as
metabolic
disorders,
atherogenesis,
carcinogenesis,
etc.
The
present
survey
aims
analyze
the
natural
compounds
that
can
act
agonists
for
PPAR-α,
PPAR-β/δ,
PPAR-γ
system
targeting,
highlighting
how
amazing
biochemical
diversity
of
yield
new
insights
into
this
“hotspot”
scientific
field.
Methods:
A
narrative
review
was
performed
by
searching
recent
international
literature
last
two
decades
in
most
authoritative
databases,
like
PubMed,
Scopus,
Web
Science,
Embase,
using
appropriate
keywords.
Results:
Several
and/or
their
synthetic
derivatives
ligands
PPARs,
stimulating
transcriptional
activity
enabling
use
preventive
therapeutic
agents
disease
states,
inflammation,
oxidative
stress,
disturbances,
carcinogenesis.
Although
are
increasingly
used
drugs
manage
health
problems,
serious
side
effects
have
been
observed,
while
analogues
exhibit
only
few
minor
effects.
Conclusions:
Further
clinical
studies
on
PPARs
evaluation
molecular
mechanisms
needed
implement
an
effective
strategy
concerning
pharmaco-technology,
food
chemistry,
nutrition
introduce
them
part
dietary
practice.
Nutrition Research and Practice,
Journal Year:
2024,
Volume and Issue:
18(6), P. 774 - 774
Published: Jan. 1, 2024
Atherosclerosis
is
a
primary
cause
of
cardiovascular
disease
associated
with
inflammation
and
lipid
metabolism
disorders.
The
accumulation
cholesterol-containing
macrophage
foam
cells
characterizes
the
early
stages.
