Predicting Severe COVID-19 Outcomes in the Elderly: The Role of Systemic Immune Inflammation, Liver Function Tests, and Neutrophil-to-Lymphocyte Ratio DOI Open Access

Adrian Vasile Bota,

Felicia Marc,

Adelina Mavrea

et al.

Healthcare, Journal Year: 2024, Volume and Issue: 12(23), P. 2429 - 2429

Published: Dec. 3, 2024

: Patients aged 80 years and above are at increased risk for severe COVID-19 outcomes. This study aimed to evaluate the prognostic utility of derived neutrophil-to-lymphocyte ratio (dNLR), aspartate-aminotransferase-to-lymphocyte index (ALRI), aspartate-aminotransferase-to-platelet (APRI), systemic immune inflammation (SII) in predicting disease, intensive care unit (ICU) admission, mortality among patients older.

Language: Английский

AGING THROUGH THE LENS OF THE GUT MICROBIOME: CHALLENGES AND THERAPEUTIC OPPORTUNITIES DOI Creative Commons

N.V. Kanimozhi,

M. Sukumar

Archives of Gerontology and Geriatrics Plus, Journal Year: 2025, Volume and Issue: unknown, P. 100142 - 100142

Published: March 1, 2025

Language: Английский

Citations

0
Rosuvastatin restores liver tissue-resident NK cell activation in aged mice by improving mitochondrial function DOI
Johnny Amer,

Ahmad Salhab,

Rifaat Safadi

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2025, Volume and Issue: 186, P. 118000 - 118000

Published: March 24, 2025

Language: Английский

Citations

0
Risk of Neutropenia Associated With Duloxetine DOI

Masahiro Ono,

S Eguchi,

Tetsuya Hagiwara

et al.

Journal of Clinical Psychopharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: March 26, 2025

Language: Английский

Citations

0
Current status of research on the role of natural products and their active ingredients in the treatment of cardiovascular aging: a narrative review DOI
Luying Zhang, Hongyan Pei, Muhammad Akmal

et al.

Aging advances., Journal Year: 2025, Volume and Issue: 2(2), P. 67 - 74

Published: April 8, 2025

Aging is a multifaceted physiological process marked by alterations in human appearance and the progressive decline organ function. With intensification of global population aging, health older individuals has emerged as critical concern, particularly given significant impact cardiovascular aging on overall outcomes. Although an inevitable natural process, strategies aimed at delaying its progression can enhance In recent years, products have garnered increasing attention for their potential disease intervention, attributed to high efficacy relatively low side-effect profiles. These demonstrated anti-aging effects several studies. This review provides comprehensive overview mechanisms underlying reviews biological activities various active constituents combating aging. It encompasses latest findings trends from both vitro vivo studies, thereby offering theoretical foundation development novel, side effect, rapidly acting drugs that target Natural exert anti-cardiovascular through multiple mechanisms, including antioxidant activity, apoptosis inhibition, anti-thrombosis, anti-fibrosis, anti-atherosclerosis, blood pressure regulation. For instance, water-soluble components Salvia miltiorrhiza , such tanshinone salvianolic acid B, improve function modulating oxidative stress inflammatory responses. Ligustrazine Rhizoma Chuanxiong reduces myocardial injury activating phosphatidylinositol 3-kinase-protein kinase B signaling pathway, whereas Ginkgo biloba leaf extract enhances vascular regulating inflammation. Additionally, animal-derived products, antler peptides royal jelly, cardioprotective effects. However, current studies possess limitations, with insufficient evidence supporting clinical application many products. Their long-term safety humans require further validation. Despite these challenges, hold improving among elderly. continued research into action advancement trials, they are expected become important tools enhancing quality life Future should explore develop safer more effective drugs, contributing positively societal health.

Language: Английский

Citations

0
Unveiling the Interconnected Dynamics of Mitochondrial Dysfunction Associated With Age-Related Cardiovascular Risk: A Cross-Sectional Pilot Study DOI Open Access
Nikita Soni,

Prasan Kaur,

Vikas Gurjar

et al.

Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: April 25, 2025

Language: Английский

Citations

0
Integrating aging biomarkers and immune function to predict kidney health: insights from the future of families and child wellbeing study DOI
Saanie Sulley, Zhou Yan,

Memory Ndanga

et al.

GeroScience, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 21, 2024

Language: Английский

Citations

1
Advances in Understanding Diabetic Kidney Disease Progression and the Mechanisms of Acupuncture Intervention DOI Creative Commons
Shan Jiang, Ziyi Cao, Siming Yu

et al.

International Journal of General Medicine, Journal Year: 2024, Volume and Issue: Volume 17, P. 5593 - 5609

Published: Nov. 1, 2024

Diabetic kidney disease (DKD) is a form of damage resulting from diabetes and represents common, severe complication the disease. Globally, DKD leading cause chronic (CKD). occurs in both type 1 2 patients, with early clinical manifestations including microalbuminuria hypertension. As condition progresses, symptoms such as massive proteinuria, hypoalbuminemia, edema may appear. The key to treating lies controlling blood glucose pressure, reducing slowing deterioration function. Acupuncture, traditional Chinese medicine treatment, has shown some therapeutic effects on through mechanisms regulating glucose, improving renal flow microcirculation, antioxidation anti-inflammation, modulating gut microbiota.

Language: Английский

Citations

0
Predicting Severe COVID-19 Outcomes in the Elderly: The Role of Systemic Immune Inflammation, Liver Function Tests, and Neutrophil-to-Lymphocyte Ratio DOI Open Access

Adrian Vasile Bota,

Felicia Marc,

Adelina Mavrea

et al.

Healthcare, Journal Year: 2024, Volume and Issue: 12(23), P. 2429 - 2429

Published: Dec. 3, 2024

: Patients aged 80 years and above are at increased risk for severe COVID-19 outcomes. This study aimed to evaluate the prognostic utility of derived neutrophil-to-lymphocyte ratio (dNLR), aspartate-aminotransferase-to-lymphocyte index (ALRI), aspartate-aminotransferase-to-platelet (APRI), systemic immune inflammation (SII) in predicting disease, intensive care unit (ICU) admission, mortality among patients older.

Language: Английский

Citations

0