Genotype-Phenotype Correlations in Inherited Cardiomyopathies, Their Role in Clinical Decision-Making and Implications in Personalized Cardiac Medicine in Multi-omics as Well as Disease Modelling Eras DOI Open Access

Yaqob Samir Taleb,

Paras Memon,

Aftab Ahmed Jalbani

et al.

Published: Aug. 9, 2024

Inherited cardiomyopathies are a diverse group of heart muscle diseases caused by genetic mutations that result in structural and functional abnormalities the myocardium. Understanding genotype-phenotype correlations these conditions is vital for personalized cardiac medicine, enabling targeted therapeutic strategies predictive diagnostics. This review explores major types inherited cardiomyopathies—hypertrophic cardiomyopathy (HCM), dilated (DCM), arrhythmogenic right ventricular (ARVC), restrictive (RCM)—and provides detailed insights into how different manifest as clinical features. The integration multi-omics approaches advanced disease modeling techniques has enhanced our ability to dissect correlations. also discusses implications findings including tailored strategies, diagnostics, future research directions.

Language: Английский

Genotype–phenotype correlations in inherited cardiomyopathies, their role in clinical decision-making, and implications in personalized cardiac medicine in multi-omics as well as disease modeling eras DOI Creative Commons

Yaqob Samir Taleb,

Paras Memon,

Aftab Ahmed Jalbani

et al.

Saudi Journal for Health Sciences, Journal Year: 2025, Volume and Issue: 14(1), P. 30 - 41

Published: Jan. 1, 2025

Inherited cardiomyopathies are a diverse group of heart muscle diseases caused by genetic mutations that result in structural and functional abnormalities the myocardium. Understanding genotype–phenotype correlations these conditions is vital for personalized cardiac medicine, enabling targeted therapeutic strategies predictive diagnostics. This review explores major types inherited cardiomyopathies–hypertrophic cardiomyopathy, dilated arrhythmogenic restrictive cardiomyopathy–and provides detailed insights into how different manifest as clinical features. The integration multi-omics approaches advanced disease modeling techniques has enhanced our ability to dissect correlations. also discusses implications findings including tailored strategies, diagnostics, future research directions. JOURNAL/sjfhs/04.03/01772839-202501000-00004/figure1/v/2025-04-19T121403Z/r/image-tiff

Language: Английский

Citations

0
Genotype-Phenotype Correlations in Inherited Cardiomyopathies, Their Role in Clinical Decision-Making and Implications in Personalized Cardiac Medicine in Multi-omics as Well as Disease Modelling Eras DOI Open Access

Yaqob Samir Taleb,

Paras Memon,

Aftab Ahmed Jalbani

et al.

Published: Aug. 9, 2024

Inherited cardiomyopathies are a diverse group of heart muscle diseases caused by genetic mutations that result in structural and functional abnormalities the myocardium. Understanding genotype-phenotype correlations these conditions is vital for personalized cardiac medicine, enabling targeted therapeutic strategies predictive diagnostics. This review explores major types inherited cardiomyopathies—hypertrophic cardiomyopathy (HCM), dilated (DCM), arrhythmogenic right ventricular (ARVC), restrictive (RCM)—and provides detailed insights into how different manifest as clinical features. The integration multi-omics approaches advanced disease modeling techniques has enhanced our ability to dissect correlations. also discusses implications findings including tailored strategies, diagnostics, future research directions.

Language: Английский

Citations

1