Shared molecular, cellular, and environmental hallmarks in cardiovascular disease and cancer: any place for drug repurposing? DOI Creative Commons
Elisa Avolio, Barbara Bassani, Marzia Campanile

et al.

Pharmacological Reviews, Journal Year: 2024, Volume and Issue: 77(2), P. 100033 - 100033

Published: Dec. 24, 2024

Cancer and cardiovascular disease (CVD) are the 2 biggest killers worldwide. Specific treatments have been developed for diseases. However, mutual therapeutic targets should be considered because of overlap cellular molecular mechanisms. research has grown at a fast pace, leading to an increasing number new mechanistic treatments. Some these drugs could prove useful treating CVD, which realizes concept cancer drug repurposing. This review provides comprehensive outline shared hallmarks primarily ischemic heart failure. We focus on chronic inflammation, altered immune response, stromal vascular cell activation, underlying signaling pathways causing pathological tissue remodeling. There is obvious scope targeting those mechanisms, thereby achieving reciprocal preventive benefits. Major attention devoted illustrating logic, advantages, challenges, viable examples repurposing discussing potential influence sex, gender, age, ethnicity in realizing this approach. Artificial intelligence will help refine personalized application patients with CVD. SIGNIFICANCE STATEMENT: (CVD), worldwide, share several So far, specific therapies tackle development slow compared drugs. Understanding intersection between mechanisms diseases basis therapeutics CVD treatment. approach allow rapid CVDs.

Language: Английский

Endothelial-Protective Actions of Diethylether Extract from Gentiana kochiana and Xanthone Gentiacaulein Against Oxidized LDL-Induced Injury—In Vitro Evaluation DOI Open Access
Gordana Tovilović, Nevena Zogović, Đurđica Ignjatović

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 1351 - 1351

Published: Feb. 5, 2025

Endothelial dysfunction is an early pathophysiological event in atherosclerosis. The endothelial-protective abilities of diethylether extract (EE) from the Gentiana kochiana (Gentianaceae) herb and its main component, xanthone aglycone gentiacaulein (GC), were evaluated oxidized low-density lipoprotein (oxLDL)-treated EA.hy926 endothelial cell line. EE GC actions assessed using viability assays, flow cytometry, immunoblot, DPPH, NBT, TBARS, conjugated diene formation, Griess tests. Both prevented oxLDL-induced apoptosis by reducing intracellular reactive oxygen species levels, mitochondrial depolarization, caspase activation cells. dose-dependently diminished cellular lipid peroxidation. In cell-free conditions, moderately scavenged superoxide anions had no affinity toward DPPH radicals, did not interact with either investigated free while both effectively delayed Cu²⁺-induced LDL oxidation. upregulated oxLDL-suppressed protective Akt/CREB/eNOS ERK signals restored oxLDL-reduced nitric oxide levels. Therefore, counteract oxidative stress, promoting recovery, enhancing prosurvival axis activity. Our study first to demonstrate that xanthone-rich aerial parts G. alleviate injury, underscoring their potential for cardiovascular protection.

Language: Английский

Citations

0
Omentin-1 as a promising biomarker and therapeutic target in hypertension and heart failure: a comprehensive review DOI
Mohammad Yasin Zamanian, Saba Maleki, Enwa Felix Oghenemaro

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: March 24, 2025

Language: Английский

Citations

0
Inhibition of MEK1/2 Signaling Pathway Limits M2 Macrophage Polarization and Interferes in the Dental Socket Repair Process in Mice DOI Creative Commons
Angélica Cristina Fonseca, Priscila Maria Colavite, Michelle de Campos Soriani Azevedo

et al.

Biology, Journal Year: 2025, Volume and Issue: 14(2), P. 107 - 107

Published: Jan. 21, 2025

Dental socket repair theoretically involves a constructive inflammatory immune response, which evolves from an initial M1 prevalence to subsequent M2 dominance. In this scenario, the MEK1/2 signaling pathway is allegedly involved in polarization. This study aimed evaluate impact of pharmacological inhibition local host response and outcome. C57Bl/6-WT 8-week-old male mice were submitted extraction right upper incisor treated (or not, control group) with inhibitor PD0325901 (10 mg/kg/24 h/IP, MEK1/2i analyzed at 0, 3, 7, 14 days using microcomputed tomography, histomorphometry, birefringence, immunohistochemistry, PCR array analysis. The results demonstrate that limits development over time, being associated lower expression M2, MSCs, bone markers, levels growth osteogenic factors, along higher iNOS, IL-1b, IL-6, TNF-α, as well chemokines, indicating predominantly pro-inflammatory environment. modulation impaired formation demonstrated by microtomographic histomorphometric data. show delays after tooth extraction, supporting concept macrophages are essential elements for regulation proper repair.

Language: Английский

Citations

0
Shared molecular, cellular, and environmental hallmarks in cardiovascular disease and cancer: any place for drug repurposing? DOI Creative Commons
Elisa Avolio, Barbara Bassani, Marzia Campanile

et al.

Pharmacological Reviews, Journal Year: 2024, Volume and Issue: 77(2), P. 100033 - 100033

Published: Dec. 24, 2024

Cancer and cardiovascular disease (CVD) are the 2 biggest killers worldwide. Specific treatments have been developed for diseases. However, mutual therapeutic targets should be considered because of overlap cellular molecular mechanisms. research has grown at a fast pace, leading to an increasing number new mechanistic treatments. Some these drugs could prove useful treating CVD, which realizes concept cancer drug repurposing. This review provides comprehensive outline shared hallmarks primarily ischemic heart failure. We focus on chronic inflammation, altered immune response, stromal vascular cell activation, underlying signaling pathways causing pathological tissue remodeling. There is obvious scope targeting those mechanisms, thereby achieving reciprocal preventive benefits. Major attention devoted illustrating logic, advantages, challenges, viable examples repurposing discussing potential influence sex, gender, age, ethnicity in realizing this approach. Artificial intelligence will help refine personalized application patients with CVD. SIGNIFICANCE STATEMENT: (CVD), worldwide, share several So far, specific therapies tackle development slow compared drugs. Understanding intersection between mechanisms diseases basis therapeutics CVD treatment. approach allow rapid CVDs.

Language: Английский

Citations

1