The impact of immune-related adverse events on the outcome of advanced gastric cancer patients with immune checkpoint inhibitor treatment DOI Creative Commons
Tianhang Zhang, Haitao Lv,

J. Li

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 24, 2024

Background The occurrence of immune-related adverse events (irAEs) seemed to be associated with better outcomes in advanced gastric cancer (AGC) patients. However, research focusing on the impact single-organ irAE (uni-irAE) or multi-organ irAEs (multi-irAEs) AGC outcome is relatively limited. In this study, we investigated individually different survival as well co-occurrence patterns multi-irAEs. Methods uni-irAE, multi-irAEs, and non-irAE were identified based National Comprehensive Cancer Network (NCCN) guidelines. ICI efficacy for disease control rate (DCR) objective response (ORR) was assessed Response Evaluation Criteria Solid Tumors (RECIST) Version 1.1. association progression-free (PFS) overall (OS) analyzed using Kaplan–Meier method Cox regression model. We also performed pairwise correlation analysis identify irAEs. Results A total 288 patients including 175 non-irAE, 73 40 multi-irAE evaluated their outcome. displayed higher DCR (78.8% vs. 67.4%, p =0.037) when compared those patients, both uni-irAE (82.2% =0.019) (72.5% =0.534) showed than that multivariate analyses revealed multi-irAEs an independent risk factor PFS (hazard ratio [HR] 0.63, 95% confidence interval [CI] 0.41~0.96, =0.031) OS (HR 0.47, CI 0.29~0.76, =0.002), whereas not obtained. thyroid, adrenal gland, heart, skin, lung exhibited a high organ-specific experiencing skin had favorable without these Conclusion Multi-irAEs some can used predictive indicators treatment are often accompanied by occurrence.

Language: Английский

Extracorporeal photopheresis vs. systemic immunosuppression for immune-related adverse events: Interim analysis of a prospective two-arm study DOI Creative Commons

Claudia Ertl,

T. Ruf,

Linda Hammann

et al.

European Journal of Cancer, Journal Year: 2024, Volume and Issue: 212, P. 115049 - 115049

Published: Sept. 27, 2024

Language: Английский

Citations

4
Autopsy Results and Registry Data: Two Sides of One Coin DOI

Umberto Macciò,

Zsuzsanna Varga,

H. Moch

et al.

Modern Pathology, Journal Year: 2025, Volume and Issue: 38(4), P. 100732 - 100732

Published: Feb. 22, 2025

Language: Английский

Citations

0
Optimized monitoring for immune checkpoint inhibitor induced Myocarditis using high-sensitivity troponin-T DOI Creative Commons
Dirk Tomsitz, Ulrich Grabmaier, Judith Spiro

et al.

European Journal of Cancer, Journal Year: 2024, Volume and Issue: 216, P. 115186 - 115186

Published: Dec. 15, 2024

Language: Английский

Citations

0
The impact of immune-related adverse events on the outcome of advanced gastric cancer patients with immune checkpoint inhibitor treatment DOI Creative Commons
Tianhang Zhang, Haitao Lv,

J. Li

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 24, 2024

Background The occurrence of immune-related adverse events (irAEs) seemed to be associated with better outcomes in advanced gastric cancer (AGC) patients. However, research focusing on the impact single-organ irAE (uni-irAE) or multi-organ irAEs (multi-irAEs) AGC outcome is relatively limited. In this study, we investigated individually different survival as well co-occurrence patterns multi-irAEs. Methods uni-irAE, multi-irAEs, and non-irAE were identified based National Comprehensive Cancer Network (NCCN) guidelines. ICI efficacy for disease control rate (DCR) objective response (ORR) was assessed Response Evaluation Criteria Solid Tumors (RECIST) Version 1.1. association progression-free (PFS) overall (OS) analyzed using Kaplan–Meier method Cox regression model. We also performed pairwise correlation analysis identify irAEs. Results A total 288 patients including 175 non-irAE, 73 40 multi-irAE evaluated their outcome. displayed higher DCR (78.8% vs. 67.4%, p =0.037) when compared those patients, both uni-irAE (82.2% =0.019) (72.5% =0.534) showed than that multivariate analyses revealed multi-irAEs an independent risk factor PFS (hazard ratio [HR] 0.63, 95% confidence interval [CI] 0.41~0.96, =0.031) OS (HR 0.47, CI 0.29~0.76, =0.002), whereas not obtained. thyroid, adrenal gland, heart, skin, lung exhibited a high organ-specific experiencing skin had favorable without these Conclusion Multi-irAEs some can used predictive indicators treatment are often accompanied by occurrence.

Language: Английский

Citations

0