Metabolic Dysfunction-Associated Steatotic Liver Disease: Pathogenetic Links to Cardiovascular Risk

Biomolecules, Journal Year: 2025, Volume and Issue: 15(2), P. 163 - 163

Published: Jan. 22, 2025

Metabolic dysfunction-associated steatotic liver disease (MASLD) is correlated with an increased cardiovascular risk, independent of other traditional risk factors. The mechanisms underlying this pathogenic link are complex yet remain incompletely elucidated. Among these, the most significant visceral adiposity, low-grade inflammation and oxidative stress, endothelial dysfunction, prothrombotic status, insulin resistance, dyslipidemia postprandial hyperlipemia, gut dysbiosis, genetic mutations. Cardiovascular diseases leading cause death in patients MASLD. These have incidence coronary artery disease, carotid structural functional cardiac abnormalities, valvulopathies, as well arrhythmias conduction disorders. In review, we present latest data on association between MASLD focusing that explain correlation these two pathologies. Given high rates morbidity mortality among MASLD, consider it imperative to raise awareness risks associated condition within general population. Further research essential clarify linked This understanding may facilitate identification new diagnostic prognostic biomarkers for patients, novel therapeutic targets.

Language: Английский

Insulin resistance has closer correlation with the occurrence of metabolic dysfunction associated steatotic liver disease diagnosed by liver biopsy

Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11

Published: Nov. 15, 2024

Objective To explore any correlation between serum urate (SU) level or insulin resistance (IR) and metabolic dysfunction associated steatotic liver disease (MASLD) in patients with syndrome (MS). Methods Data from all MASLD patients, diagnosed by biopsy, were enrolled divided into alone group MS group. They subdivided hyperuricemia normal SU to find SU/IR independent risk factors for MASLD. Results 539 analyzed. Body mass index (BMI) ( p = 0.000), waist circumference (WC) 0.004), low-density lipoprotein (LDL) 0.000) dramatically higher than those alone; had significantly more family history of diabetes hypertension alone. Height weight BMI WC 0.001), LDL 0.007) SU. was inversely age high-density (HDL) 0.003), positively correlated TG 0.000). Logistic Regression analysis showed that 0.031), 0.002), 0.010), HbA1c 0.026), may be patient MS. Conclusion Insulin MS, but not levels, has closer the occurrence having BMI, LDL, HbA1c.

Language: Английский

The association between triglyceride-glucose index and neutrophil-lymphocyte ratio and all-cause mortality in the general US population: NHANES 2001–2018

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 10, 2024

The association between the triglyceride-glucose (TyG) index and mortality in general population remains controversial, with inconsistent findings across studies.

Language: Английский