Apolipoprotein B and Glycemic Dysregulation: New Predictors of Type 2 Diabetes in High-Cardiovascular-Risk Populations DOI Open Access
Makhabbat Bekbossynova, T Ivanova-Razumova,

Aknur Kali

et al.

Journal of Personalized Medicine, Journal Year: 2025, Volume and Issue: 15(5), P. 163 - 163

Published: April 23, 2025

Background: Apolipoprotein B (ApoB), a key component of atherogenic lipoproteins, has been increasingly implicated in cardiometabolic disorders beyond dyslipidemia. However, its role glycemic dysregulation remains unclear. This study aimed to investigate the association between ApoB levels and parameters, including fasting glucose, insulin resistance, glycated hemoglobin (HbA1c), individuals without diagnosed diabetes. Methods: was conducted at National Research Cardiac Surgery Center (Kazakhstan) over period 2023 2024 as cross-sectional analysis. Adults aged ≥ 20 years diabetes with complete data on their markers were included. Associations plasma glucose (FPG), HbA1c, HOMA-IR assessed using multivariable linear logistic regression models adjusted for demographic, lifestyle, metabolic covariates. Results: Higher significantly associated increased (β = 2.07 mg/dL per 1-SD increase ApoB, p < 0.001), higher HbA1c 0.06%, elevated 0.54, 0.001). Participants highest quartile had 53% odds prediabetes (adjusted OR 1.53; 95% CI: 1.22–1.91; 0.001) compared lowest quartile. These associations remained significant after adjusting BMI, lipid levels, other confounders. Conclusions: Elevated is independently adverse profiles nondiabetic individuals, suggesting potential early metabolism disturbances.

Language: Английский

Apolipoprotein B and Glycemic Dysregulation: New Predictors of Type 2 Diabetes in High-Cardiovascular-Risk Populations DOI Open Access
Makhabbat Bekbossynova, T Ivanova-Razumova,

Aknur Kali

et al.

Journal of Personalized Medicine, Journal Year: 2025, Volume and Issue: 15(5), P. 163 - 163

Published: April 23, 2025

Background: Apolipoprotein B (ApoB), a key component of atherogenic lipoproteins, has been increasingly implicated in cardiometabolic disorders beyond dyslipidemia. However, its role glycemic dysregulation remains unclear. This study aimed to investigate the association between ApoB levels and parameters, including fasting glucose, insulin resistance, glycated hemoglobin (HbA1c), individuals without diagnosed diabetes. Methods: was conducted at National Research Cardiac Surgery Center (Kazakhstan) over period 2023 2024 as cross-sectional analysis. Adults aged ≥ 20 years diabetes with complete data on their markers were included. Associations plasma glucose (FPG), HbA1c, HOMA-IR assessed using multivariable linear logistic regression models adjusted for demographic, lifestyle, metabolic covariates. Results: Higher significantly associated increased (β = 2.07 mg/dL per 1-SD increase ApoB, p < 0.001), higher HbA1c 0.06%, elevated 0.54, 0.001). Participants highest quartile had 53% odds prediabetes (adjusted OR 1.53; 95% CI: 1.22–1.91; 0.001) compared lowest quartile. These associations remained significant after adjusting BMI, lipid levels, other confounders. Conclusions: Elevated is independently adverse profiles nondiabetic individuals, suggesting potential early metabolism disturbances.

Language: Английский

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