Association between lactate-to-albumin ratio and all-cause mortality in critically ill cirrhotic patients with sepsis: a retrospective analysis of the MIMIC-IV database DOI Creative Commons
Yuanji Ma,

Lingyao Du,

Lang Bai

et al.

BMC Gastroenterology, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 24, 2025

The impact of lactate-to-albumin ratio (LAR) on mortality critically ill cirrhotic patients with sepsis is scant. Critically were obtained from the MIMIC-IV database (v3.0). Cox regression models alone and in combination restricted cubic splines, generalized additive smoothed curve fitting used to investigate relationship between LAR all-cause mortality. A total 1864 included. 30-day, 90-day, 180-day rates 38.0%, 46.3%, 49.5%, respectively. Higher significantly nonlinearly associated higher risks (all adjusted HR = 1.17, P < 0.001). L-shaped associations observed, an inflection point 1.05 (P for log-likelihood 0.01). Compared 1.05, ≥ had (adjusted (95% CI): 1.48 (1.27–1.72), 1.44 (1.25–1.66), 1.38 (1.21–1.57), respectively). No potential modifiers found was positively sepsis. Thus, it could be as a prognostic biomarker.

Language: Английский

Association between lactate-to-albumin ratio and all-cause mortality in critically ill cirrhotic patients with sepsis: a retrospective analysis of the MIMIC-IV database DOI Creative Commons
Yuanji Ma,

Lingyao Du,

Lang Bai

et al.

BMC Gastroenterology, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 24, 2025

The impact of lactate-to-albumin ratio (LAR) on mortality critically ill cirrhotic patients with sepsis is scant. Critically were obtained from the MIMIC-IV database (v3.0). Cox regression models alone and in combination restricted cubic splines, generalized additive smoothed curve fitting used to investigate relationship between LAR all-cause mortality. A total 1864 included. 30-day, 90-day, 180-day rates 38.0%, 46.3%, 49.5%, respectively. Higher significantly nonlinearly associated higher risks (all adjusted HR = 1.17, P < 0.001). L-shaped associations observed, an inflection point 1.05 (P for log-likelihood 0.01). Compared 1.05, ≥ had (adjusted (95% CI): 1.48 (1.27–1.72), 1.44 (1.25–1.66), 1.38 (1.21–1.57), respectively). No potential modifiers found was positively sepsis. Thus, it could be as a prognostic biomarker.

Language: Английский

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