Transplantation of Fecal Flora from Patients with Atherosclerosis to Mice Can Increase Serum Low-Density Lipoprotein Cholesterol and Affect Intestinal Flora and Its Metabolites DOI Creative Commons

Liang Feng,

J. Feng,

Li He

et al.

Applied Microbiology, Journal Year: 2025, Volume and Issue: 5(1), P. 29 - 29

Published: March 13, 2025

Atherosclerosis (AS) is emerging as a major global public health problem. Researchers are developing and implementing various anti-AS strategies. This study aimed to investigate gut microbiota metabolite changes associated with elevated serum low-density lipoprotein cholesterol (LDL-c). Mice were divided into two equal groups: Group C (mice from healthy subjects) B AS). At the end of 8-week study, blood samples collected for lipid analysis; rectal feces microbial 16S rRNA sequencing analysis metabolomics analysis. Our results showed that group significantly increased levels LDL-c. However, no statistically significant differences observed in richness diversity microbiota, but we an increase ratio Firmicutes Bacteroidetes abundance Parabacteroides Goldstein. In addition, untargeted metabolomic fecal revealed 128 metabolites differentially expressed between groups B. Notably, was found have involved metabolism pathways, such estrogen glucuronide, ginsenoside f1, Pe (16:1e/14,15-epete), prostaglandin E1. Those data highlight importance understanding AS perspective establish foundation future research on AS.

Language: Английский

Transplantation of Fecal Flora from Patients with Atherosclerosis to Mice Can Increase Serum Low-Density Lipoprotein Cholesterol and Affect Intestinal Flora and Its Metabolites DOI Creative Commons

Liang Feng,

J. Feng,

Li He

et al.

Applied Microbiology, Journal Year: 2025, Volume and Issue: 5(1), P. 29 - 29

Published: March 13, 2025

Atherosclerosis (AS) is emerging as a major global public health problem. Researchers are developing and implementing various anti-AS strategies. This study aimed to investigate gut microbiota metabolite changes associated with elevated serum low-density lipoprotein cholesterol (LDL-c). Mice were divided into two equal groups: Group C (mice from healthy subjects) B AS). At the end of 8-week study, blood samples collected for lipid analysis; rectal feces microbial 16S rRNA sequencing analysis metabolomics analysis. Our results showed that group significantly increased levels LDL-c. However, no statistically significant differences observed in richness diversity microbiota, but we an increase ratio Firmicutes Bacteroidetes abundance Parabacteroides Goldstein. In addition, untargeted metabolomic fecal revealed 128 metabolites differentially expressed between groups B. Notably, was found have involved metabolism pathways, such estrogen glucuronide, ginsenoside f1, Pe (16:1e/14,15-epete), prostaglandin E1. Those data highlight importance understanding AS perspective establish foundation future research on AS.

Language: Английский

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