Unraveling the SARS-CoV-2 spike protein long-term effect on neuro-PASC DOI Creative Commons
Filipe Menezes, Julys da Fonseca Palmeira, Juliana dos Santos Oliveira

et al.

Frontiers in Cellular Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: Dec. 18, 2024

The persistence or emergence of long-term symptoms following resolution primary SARS-CoV-2 infection is referred to as long COVID post-acute sequelae COVID-19 (PASC). PASC predominantly affects the cardiovascular, neurological, respiratory, gastrointestinal, reproductive, and immune systems. Among these, central nervous system (CNS) significantly impacted, leading a spectrum symptoms, including fatigue, headaches, brain fog, cognitive impairment, anosmia, hypogeusia, neuropsychiatric peripheral neuropathy (neuro-PASC). However, risk factors pathogenic mechanisms responsible for neuro-PASC remain unclear. This review hypothesis discusses hypotheses regarding pathophysiological involved in COVID/PASC, focusing on neuro-PASC. We propose vascular dysfunction mediated by activation astrocytes pericytes followed blood-brain barrier (BBB) disruption underlying neurological manifestations. Additionally, we provide insights into role spike protein at interface. Finally, explore potential initiated interaction between cellular receptors endothelial tissue levels.

Language: Английский

Unraveling the SARS-CoV-2 spike protein long-term effect on neuro-PASC DOI Creative Commons
Filipe Menezes, Julys da Fonseca Palmeira, Juliana dos Santos Oliveira

et al.

Frontiers in Cellular Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: Dec. 18, 2024

The persistence or emergence of long-term symptoms following resolution primary SARS-CoV-2 infection is referred to as long COVID post-acute sequelae COVID-19 (PASC). PASC predominantly affects the cardiovascular, neurological, respiratory, gastrointestinal, reproductive, and immune systems. Among these, central nervous system (CNS) significantly impacted, leading a spectrum symptoms, including fatigue, headaches, brain fog, cognitive impairment, anosmia, hypogeusia, neuropsychiatric peripheral neuropathy (neuro-PASC). However, risk factors pathogenic mechanisms responsible for neuro-PASC remain unclear. This review hypothesis discusses hypotheses regarding pathophysiological involved in COVID/PASC, focusing on neuro-PASC. We propose vascular dysfunction mediated by activation astrocytes pericytes followed blood-brain barrier (BBB) disruption underlying neurological manifestations. Additionally, we provide insights into role spike protein at interface. Finally, explore potential initiated interaction between cellular receptors endothelial tissue levels.

Language: Английский

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