Breaking the resistance: integrative approaches with novel therapeutics against Klebsiella pneumoniae DOI

V. K. Koul,

Apoorva Sharma,

Diksha Kumari

et al.

Archives of Microbiology, Journal Year: 2024, Volume and Issue: 207(1)

Published: Dec. 26, 2024

Language: Английский

An Insight into Bacteriocins for Combating Microbial Infections and Ensuring Food Safety DOI

Mithu Howlader,

Shuvo Chandra Das, Shipan Das Gupta

et al.

International Journal of Peptide Research and Therapeutics, Journal Year: 2025, Volume and Issue: 31(2)

Published: Feb. 6, 2025

Language: Английский

Citations

1
Second harmonic generation-mediated Photodynamic Therapy for Staphylococcus aureus: A novel approach using Bismuth Ferrite-Protoporphyrin IX conjugates DOI Creative Commons

Manu Kumar,

Avinash Jukanti,

Rivka Cahan

et al.

Photodiagnosis and Photodynamic Therapy, Journal Year: 2025, Volume and Issue: unknown, P. 104512 - 104512

Published: Feb. 1, 2025

Photodynamic therapy (PDT) is a minimally invasive treatment modality that utilizes photosensitizing agents, light, and molecular oxygen to produce cytotoxic reactive species (ROS) treat cancerous cells bacterial infections. However, the effectiveness of PDT often limited by penetration depth light used activate photosensitizer (PS). We propose an effective method address this challenge using Second Harmonic Generation (SHG), nonlinear optical process in which two identical photons combine form new photon with double frequency. This technique enables utilization longer wavelengths for enhanced tissue penetration, subsequently converting them into shorter align absorption characteristics photosensitizer. Thus, achieve highly production SHG, we successfully synthesized Nanoparticle (HNP), Bismuth Ferrite (BFO). Subsequently, BFO was conjugated Protoporphyrin IX (PPIX) get BFO-PPIX conjugates treatment. These were exposed Near Infrared (NIR) femtoseconds pulsed laser wavelength 798 nm. experiments 8-minute irradiation nm pulse reduced survival rate cultured Staphylococcus aureus (S. aureus) 44.5% ± 3.4%. To best our knowledge, have not been previously advancing conventional SHG deeper precise S. aureus.

Language: Английский

Citations

0
Recent insights on phage therapy against multidrug-resistant Acinetobacter baumannii DOI Creative Commons
Ann A. Elshamy, Salwa M. Kamal, Mohamed Basyony

et al.

AMB Express, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 12, 2025

Abstract Acinetobacter baumannii is a prevalent clinical pathogen commonly found to be multidrug-resistant (MDR), causing serious life-threatening infections, particularly hospital-acquired infections with limited therapeutic options. The MDR phenotype developed against this critical increasingly globally, reaching pan-drug-resistant conferring non-susceptibility all antimicrobials used in its treatment according the standard guidelines. Therefore, it develop innovative approaches, such as phage therapy, considering rise drug-resistant A. infections. In review, we highlight and discuss up-to-date antimicrobial resistance of , use phages, their limitations, future perspectives treating addition, combination phages antimicrobials, preclinical studies including pharmacokinetics pharmacodynamics properties have been discussed.

Language: Английский

Citations

0
“Genomic Adaptations of Methicillin-Resistant Staphylococcus aureus in Healthcare Environments” DOI

Vishnu Priya Panneerselvam,

Leela Kagithakara Vajravelu,

Jayaprakash Thulukanam

et al.

Ecological Genetics and Genomics, Journal Year: 2025, Volume and Issue: unknown, P. 100331 - 100331

Published: Jan. 1, 2025

Language: Английский

Citations

0
Breaking the resistance: integrative approaches with novel therapeutics against Klebsiella pneumoniae DOI

V. K. Koul,

Apoorva Sharma,

Diksha Kumari

et al.

Archives of Microbiology, Journal Year: 2024, Volume and Issue: 207(1)

Published: Dec. 26, 2024

Language: Английский

Citations

1