An update on bone in diabetes DOI

Ornpicha Laohajaroensombat,

Methavee Poochanasri,

Parinya Samakkarnthai

et al.

Current Opinion in Endocrinology Diabetes and Obesity, Journal Year: 2025, Volume and Issue: unknown

Published: April 10, 2025

Purpose of review As the prevalence diabetes mellitus (DM) increases due to urbanization, aging populations, and lifestyle changes, it is crucial understand mechanisms, diagnosis, treatment diabetes-related bone disorders. This highlights recent advancements in field explores their implications for clinical practice research. Recent findings studies have elucidated complex interplay between health, emphasizing roles advanced glycation end-products (AGEs), inflammation, oxidative stress, senescence, molecular signaling pathways such as Wnt, mammalian target rapamycin (mTOR), exosome-mediated mechanisms. Key highlight significance marrow adipose tissue (BMAT) metabolism impact sarcopenia on fracture risk. Novel diagnostic tools, including miRNA biomarkers emerging therapeutic strategies like exosome-based therapies glycogen synthase kinase 3 beta (GSK3β) inhibitors, offer promising opportunities improving health diabetic patients. Summary The underscore need integrated managing complications. Clinicians should prioritize early screening, interventions, personalized pharmacological treatments mitigate risk improve Future research focus optimizing tools developing targeted address unique challenges disorders related diabetes.

Language: Английский

An update on bone in diabetes DOI

Ornpicha Laohajaroensombat,

Methavee Poochanasri,

Parinya Samakkarnthai

et al.

Current Opinion in Endocrinology Diabetes and Obesity, Journal Year: 2025, Volume and Issue: unknown

Published: April 10, 2025

Purpose of review As the prevalence diabetes mellitus (DM) increases due to urbanization, aging populations, and lifestyle changes, it is crucial understand mechanisms, diagnosis, treatment diabetes-related bone disorders. This highlights recent advancements in field explores their implications for clinical practice research. Recent findings studies have elucidated complex interplay between health, emphasizing roles advanced glycation end-products (AGEs), inflammation, oxidative stress, senescence, molecular signaling pathways such as Wnt, mammalian target rapamycin (mTOR), exosome-mediated mechanisms. Key highlight significance marrow adipose tissue (BMAT) metabolism impact sarcopenia on fracture risk. Novel diagnostic tools, including miRNA biomarkers emerging therapeutic strategies like exosome-based therapies glycogen synthase kinase 3 beta (GSK3β) inhibitors, offer promising opportunities improving health diabetic patients. Summary The underscore need integrated managing complications. Clinicians should prioritize early screening, interventions, personalized pharmacological treatments mitigate risk improve Future research focus optimizing tools developing targeted address unique challenges disorders related diabetes.

Language: Английский

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