Burns, Journal Year: 2022, Volume and Issue: 49(2), P. 476 - 480
Published: Aug. 30, 2022
Language: Английский
Journal of Clinical Medicine, Journal Year: 2021, Volume and Issue: 10(5), P. 1085 - 1085
Published: March 5, 2021
Background: The first objective of this review was to present, based on recent literature, the most frequently applied medical options (oral contraceptive pills (OCPs) and progestogens) for management symptomatic endometriosis, evaluate their effectiveness in treating premenopausal women with endometriosis-associated pelvic pain, dysmenorrhea, non-menstrual pain dyspareunia. second concept progesterone resistance newly available treatment options. Methods: We reviewed relevant papers (n = 73) efficacy OCPs progestogens as therapy well those new alternatives gonadotropin-releasing hormone (GnRH) antagonist). Eleven papers, essentially reviews, were selected scrutinized from among 94 discussing resistance. Results: Having significant we can confirm that are effective two-thirds suffering but other required case failure (in one-third due resistance) or intolerance these compounds. It is clear there a need long-term oral capable managing endometriosis symptoms, while mitigating impact side effects. Biochemical, histological clinical evidence show estrogens play critical role pathogenesis so lowering levels circulating should be considered an approach. three GnRH antagonists discussed basis published studies. Conclusion: There place trials conducted, taking into account different phenotypes order propose novel algorithms.
Language: Английский
Citations
143
Fertility and Sterility, Journal Year: 2023, Volume and Issue: 119(5), P. 727 - 740
Published: March 21, 2023
We performed a comprehensive narrative synthesis of systematic reviews with meta-analysis published in the last 5 years on association endometriosis and adenomyosis reproductive obstetric outcomes. This review aimed to define information which base preconceptional counseling clarify whether cases pregnant women should be referred tertiary care centers followed as high-risk patients. Reduced pregnancy live birth rates an increased miscarriage rate were observed adenomyosis. The effect was larger than those endometriosis. Women superficial peritoneal ovarian do not appear at considerably risk major neonatal complications, whereas severe endometriosis, operated or not, are several-fold placenta previa. Moreover, deep infiltrating is factor for spontaneous hemoperitoneum associated surgical complications cesarean section. Overall, various adverse outcomes, including preeclampsia, preterm delivery, fetal malpresentation, postpartum hemorrhage, low weight, small gestational age. Most studies included considered characterized by substantial qualitative quantitative heterogeneity. makes reliable assessment available evidence difficult, caution exercised when attempting derive clinical indications. Nevertheless, high can benefit from referral where they safely through delivery. Whether same apply also minimal forms currently uncertain. Emerging suggests that some outcomes are, fact, coexisting
Language: Английский
Citations
101
Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14
Published: Feb. 14, 2023
Endometriosis, an estrogen-dependent chronic inflammatory disease characterized by the growth of endometrium-like tissues outside uterine cavity, affects 10% reproductive-age women. Although pathogenesis endometriosis is uncertain, it widely accepted that retrograde menstruation results in ectopic endometrial tissue implantation. Given not all women with develop endometriosis, immune factors have been hypothesized to affect endometriosis. In this review, we demonstrate peritoneal microenvironment, including innate immunity and adaptive immunity, plays a central role Current evidence supports fact cells, such as macrophages, natural killer (NK) dendritic cells (DCs), neutrophils, T B well cytokines mediators, contribute vascularization fibrogenesis endometriotic lesions, accelerating implantation development lesions. Endocrine system dysfunction influences microenvironment through overexpressed estrogen progesterone resistance. light limitations hormonal therapy, describe prospects for potential diagnostic biomarkers nonhormonal therapy based on regulation microenvironment. Further studies are warranted explore available immunological therapeutic strategies
Language: Английский
Citations
68
Molecular Pain, Journal Year: 2023, Volume and Issue: 19
Published: May 23, 2023
Chronic pain is a refractory health disease worldwide causing an enormous economic burden on individuals and society. Accumulating evidence suggests that inflammation in the peripheral nervous system (PNS) central (CNS) major factor pathogenesis of chronic pain. The early- late phase may have distinctive effects initiation resolution pain, which can be viewed as friend or foe. On one hand, painful injuries lead to activation glial cells immune PNS, releasing pro-inflammatory mediators, contribute sensitization nociceptors, leading pain; neuroinflammation CNS drives promotes development other macrophages PNS promote via anti-inflammatory mediators specialized pro-resolving (SPMs). In this review, we provide overview current understanding deterioration Further, summarize number novel strategies used prevent treat by controlling inflammation. This comprehensive view relationship between its specific mechanism will targets for treatment
Language: Английский
Citations
56
Science Translational Medicine, Journal Year: 2023, Volume and Issue: 15(684)
Published: Feb. 22, 2023
Current pharmacological treatments for endometriosis are limited to hormonal agents that can relieve pain but cannot cure the disease. Therefore, development of a disease-modifying drug is an unmet medical need. By studying human endometriotic samples, we found progression was associated with inflammation and fibrosis. In addition, IL-8 expression highly up-regulated in tissues closely correlated disease progression. We created long-acting recycling antibody against (AMY109) evaluated its clinical potency. Because rodents do not produce experience menstruation, analyzed lesions cynomolgus monkeys spontaneously developed surgically induced monkey model. Both demonstrated pathophysiology similar endometriosis. Once-a-month subcutaneous injection AMY109 reduced volume nodular lesions, lowered Revised American Society Reproductive Medicine score as modified monkeys, ameliorated fibrosis adhesions. experiments using cells derived from revealed inhibited recruitment neutrophils production monocyte chemoattractant protein-1 neutrophils. Thus, may represent therapy patients
Language: Английский
Citations
55
Cells, Journal Year: 2025, Volume and Issue: 14(1), P. 58 - 58
Published: Jan. 6, 2025
Endometriosis is a gynecologic condition characterized by the growth of endometrium-like stroma and glandular elements outside uterine cavity. The involvement hormonal dysregulation, specifically estrogen, well established in initiation, progression, maintenance condition. Evidence also highlights association between endometriosis altered immune states. human endometrium highly dynamic tissue that undergoes frequent remodeling response to regulation during menstrual cycle. Similarly, shares this propensity, compounded unclear pathogenic mechanisms, presenting unique challenges defining its etiology pathology. Here, we provide lens understand interplay estrogen innate adaptive systems throughout cycle pathogenesis endometriosis. Estrogen closely linked many inflammatory immunomodulatory states, affecting both tissue-resident circulatory cells. This review summarizes estrogenic interactions with specific myeloid lymphoid cells, highlighting their implications progression
Language: Английский
Citations
2
Proceedings of the National Academy of Sciences, Journal Year: 2021, Volume and Issue: 118(6)
Published: Feb. 3, 2021
Significance Endometriosis is a chronic, incurable inflammatory disorder impacting 190 million women worldwide. Immune cells called macrophages are implicated in promoting endometriosis. Macrophages have different origins and their origin can dictate function. In this study we demonstrate that endometriotic lesion-resident derived from the uterine lining (endometrium), abdominal (peritoneal) cavity, recruited bone-marrow precursors (monocytes). triggers continuous recruitment of monocytes differentiate into differ those usually present within peritoneal cavity. By depleting populations, endometrial “proendometriosis” while monocyte-derived “antiendometriosis” acting to protect cavity lesion establishment. future, immune-based therapies may allow targeting prodisease and/or harnessing antiendometriosis
Language: Английский
Citations
88
Archives of Gynecology and Obstetrics, Journal Year: 2021, Volume and Issue: 304(5), P. 1363 - 1373
Published: April 11, 2021
Language: Английский
Citations
81
Scientific Reports, Journal Year: 2021, Volume and Issue: 11(1)
Published: June 7, 2021
Abstract Endometriosis (EMS) is a disease that shows immune dysfunction and chronic inflammation characteristics, suggesting role of complement system in its pathophysiology. To find out the hub genes pathways involved pathogenesis EMs, three raw microarray datasets were recruited from Gene Expression Omnibus database (GEO). Then, series bioinformatics technologies including gene ontology (GO), Hallmark pathway enrichment, protein–protein interaction (PPI) network co-expression correlation analysis performed to identify genes. The further verified by Real-time quantitative polymerase chain reaction (RT-PCR) Western Blot (WB). We identified 129 differentially expressed (DEGs) which 78 up-regulated 51 down-regulated. Through GO functional enrichment analysis, we found DEGs are mainly enriched cell adhesion, extracellular matrix remodeling, chemokine regulation, angiogenesis epithelial proliferation, et al. In coagulation showed great significance terms included central factors. Moreover, dominating PPI network. Combined with experimental verification, expression (C1S, C1QA, C1R, C3) was positively related tissue factor (TF) EMs. this study, discovered over positive between TF suggested may play within pathophysiology EMS.
Language: Английский
Citations
67
International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(19), P. 10792 - 10792
Published: Oct. 6, 2021
Endometriosis is an estrogen-dependent gynecological disorder, defined as the growth of endometrial stromal cells and glands at extrauterine sites. Endometriotic lesions are more frequently located into abdominal cavity, although they can also be implanted in distant places. Among its etiological factors, presence immune dysregulation occupies a prominent place, pointing out beneficial harmful outcomes macrophages pathogenesis this disease. Macrophages tissue-resident that connect innate adaptive immunity, playing key role maintaining local homeostasis healthy conditions being critical development sustainment many inflammatory diseases. accumulate peritoneal cavity women with endometriosis, but their ability to clear migrated fragments seems inefficient. Hence, characteristics system endometriosis must further studied facilitate search for new diagnostic therapeutic tools. In review, we summarize recent relevant advances obtained both mouse, main animal model used study human, focusing on from endometriotic patients donors, under perspective future clinical translation these play pathology.
Language: Английский
Citations
66