First Clarification of the Involvement of Glycosyltransferase MdUGT73CG22 in the Detoxification Metabolism of Nicosulfuron in Apple

Plants, Journal Year: 2024, Volume and Issue: 13(9), P. 1171 - 1171

Published: April 23, 2024

Nicosulfuron, an acetolactate synthase (ALS) inhibitor herbicide, is a broad-spectrum and highly effective post-emergence herbicide. Glycosyltransferases (GTs) are widely found in organisms transfer sugar molecules from donors to acceptors form glycosides or esters, thereby altering the physicochemical properties of acceptor molecule, such as participating detoxification. In this study, nine glycosyltransferases group D apple glycosyltransferase family I were predicted possibly be involved detoxification metabolism ALS-inhibiting herbicides based on gene chip data published online. order confirm this, we analysed whether expression genes was induced by previously reported real-time PCR (polymerase chain reaction). It that herbicide nicosulfuron significantly increased MdUGT73CG22 D. Further investigation mechanism action revealed glycosylated modified both vivo ex glycosides, which metabolism. conclusion, new glycosyltransferase, MdUGT73CG22, identified for first time can glycosylate modifications may process plants, help further improve knowledge non-targeted herbicides.

Language: Английский

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Potential Role of Glyphosate, Glyphosate-Based Herbicides, and AMPA in Breast Cancer Development: A Review of Human and Human Cell-Based Studies

International Journal of Environmental Research and Public Health, Journal Year: 2024, Volume and Issue: 21(8), P. 1087 - 1087

Published: Aug. 17, 2024

The potential connection between exposure to glyphosate and glyphosate-based herbicides (GBHs) breast cancer risk is a topic of research that rapidly gaining the public's attention due conflicting reports surrounding glyphosate's carcinogenicity. In this review, we synthesize current published biomedical literature works have explored associations glyphosate, its metabolite, aminomethylphosphonic acid (AMPA), GBHs with in humans human cell-based models. Using PubMed as our search engine, identified total 14 articles were included review. four studies, urinary and/or AMPA associated risk, endocrine disruption, oxidative stress biomarkers, changes DNA methylation patterns. Among most 10 exhibited induced altered gene expression, increased damage, cell viability, while more cytotoxic than alone. summary, numerous studies shown AMPA, carcinogenic, cytotoxic, or endocrine-disruptive properties. However, need be conducted order for definitive supported conclusions made on their effects risk.

Language: Английский

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Maternal pesticide exposure and risk of preterm birth: A systematic review and meta-analysis

Environment International, Journal Year: 2023, Volume and Issue: 178, P. 108043 - 108043

Published: June 16, 2023

Maternal pesticide exposure might be associated with adverse pregnancy outcomes through triggering inflammation and oxidative stress disrupting endocrine functions. Yet the association between prenatal risk of preterm birth remains inconclusive. To conduct a systematic review meta-analysis human observational studies using Office Health Assessment Translation (OHAT) framework to explore per ten-fold increase concentrations in maternal biological samples during length gestational age at birth. Five English (PubMed, Embase, Cochrane Library, Web Science Scopus) 3 Chinese databases (China national knowledge infrastructure (CNKI), Wanfang Data, Biomedical Literature Database (CBM)) were searched till Jan 18th, 2023. included, should measured log-transformed forms. The primary outcome was secondary Quality evaluated OHAT Risk Bias Tool. Evidence quantitatively synthesized Correlated Hierarchical Effects (CHE) model. confidence rating body evidence done OHAT. A total 21 reported by 18 papers 7 for 19 found potentially (pooled OR = 1.28; 95%CI: 0.93, 1.78) shortened (β −0.10; −0.21, 0.01). Sampling biospecimens different trimesters identified as potential modifier (F 2.77, P < 0.05). For that collected any time pregnancy, −0.43; −0.81, −0.06). "moderate" "very low" birth, respectively. Our result suggested moderate an higher more are still needed larger sample size careful considerations confounders accuracy measurements. Attention is also required on other compounds addition organochlorine organophosphorus pesticides, windows susceptibility.

Language: Английский

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Mapping Potential Population‐Level Pesticide Exposures in Ecuador Using a Modular and Scalable Geospatial Strategy

GeoHealth, Journal Year: 2023, Volume and Issue: 7(7)

Published: July 1, 2023

Human populations and ecosystems are extensively exposed to pesticides. Most nations lack the capacity control pesticide contamination have limited availability of use information. Ecuador is a country with intense high exposure risks humans environment, although relative or combined not well understood. Here, we analyzed distribution application rates in identified regions concern because potential exposure. We used geospatial analysis identify grid cells (∼8 km × 8 km) where highest density human overlap. Furthermore, other based on number amphibian species as an indicator ecosystem integrity location natural protected areas. found that 28% Ecuador's population dwelled areas rate. area ∼512 km2 Amazon region rates, large settlements, overlapped. Additionally, distinguished clusters intersected exemplifies how pesticides disproportionately applied affect health ecosystems' integrity. Global estimates dwelling, environmental factors key prioritizing locations conduct further assessments. The modular scalable nature tools developed can be expanded adapted world data limited.

Language: Английский

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The Herbicide Glyphosate and Its Formulations Impact Animal Behavior across Taxa

Agrochemicals, Journal Year: 2023, Volume and Issue: 2(3), P. 367 - 408

Published: July 10, 2023

Use of glyphosate and glyphosate-based herbicides is ubiquitous in US agriculture widespread around the world. Despite marketing efforts to contrary, numerous studies demonstrate toxicity non-target organisms including animals, primarily focusing on mortality, carcinogenicity, renal toxicity, reproductive, neurological biochemical mechanisms underlying these physiological outcomes. Glyphosate also impacts animal behavior, both model systems agricultural environmentally relevant contexts. In this review, we examine effects behaviors, particularly activity, foraging feeding, anti-predator reproductive learning memory, social behaviors. can be detected food environment, avoided through activity feeding strategies. However, exposure reduces depresses increases susceptibility predation, interferes with courtship, mating, fertility maternal decreases memory capabilities, disrupts Changes behavior as a result are important because their sometimes severe individual fitness, well ecosystem health. Implications for human considered.

Language: Английский

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