Association of the systemic immuno-inflammation index, neutrophil-to-lymphocyte ratio, and platelet-to-lymphocyte ratio with diabetic microvascular complications

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: April 10, 2024

Background The systemic immuno-inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte (PLR) are widely used have been shown to be predictive indicators of various diseases. Diabetic nephropathy (DN), retinopathy (DR), peripheral neuropathy (DPN) the most prominent common microvascular complications, which seriously negative impacts on patients, families, society. Exploring associations with these three diabetic complications main purpose. Methods There were 1058 individuals type 2 diabetes mellitus (T2DM) in this retrospective cross-sectional study. SII, NLR, PLR calculated. diseases diagnosed by endocrinologists. Logistic regression subgroup analysis applied evaluate association between NLP, complications. Results significantly associated risk DN [odds ratios (ORs): 1.52, 1.71, 1.60, respectively] DR [ORs: 1.57, 1.79, 1.55, multivariate logistic regression. When NLR ≥2.66, OR was higher for DPN (OR: 1.985, 95% confidence interval: 1.29–3.05). Subgroup showed no significant positive across different demographics comorbidities, including sex, age, hypertension, HbA1c (glycated hemoglobin), dyslipidemia. Conclusion This study found a relationship DN, DR, DPN. In contrast, SII only DR. Therefore, diagnosis highly valuable.

Language: Английский

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Diabetic complications and prospective immunotherapy

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: July 7, 2023

The incidence of Diabetes Mellitus is increasing globally. Individuals who have been burdened with diabetes for many years often develop complications as a result hyperglycemia. More and more research being conducted highlighting inflammation an important factor in disease progression. In all kinds diabetes, hyperglycemia leads to activation alternative glucose metabolic pathways, resulting problematic by-products including reactive oxygen species advanced glycation end products. This review takes look into the pathogenesis three specific diabetic complications; retinopathy, nephropathy neuropathy well their current treatment options. By considering recent papers investigating effects immunotherapy on relevant conditions animal models, multiple strategies are suggested future prevention emphasis molecular targets associated inflammation.

Language: Английский

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Phase Angle of Bioelectrical Impedance Analysis as an Indicator for Diabetic Polyneuropathy in Type 2 Diabetes Mellitus

The Journal of Clinical Endocrinology & Metabolism, Journal Year: 2024, Volume and Issue: 109(11), P. e2110 - e2119

Published: Jan. 12, 2024

Due to the heterogenous clinical symptoms and deficits, diagnosis of diabetic polyneuropathy (DPN) is still difficult in routines, leading increased morbidity mortality.

Language: Английский

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Diabetic neuropathy: Pathogenesis and evolving principles of management

Disease-a-Month, Journal Year: 2023, Volume and Issue: 69(9), P. 101582 - 101582

Published: May 8, 2023

Language: Английский

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Screening for diabetic peripheral neuropathy in resource-limited settings

Diabetology & Metabolic Syndrome, Journal Year: 2023, Volume and Issue: 15(1)

Published: March 22, 2023

Abstract Background Diabetic neuropathy is the most common microvascular complication of diabetes mellitus and a major risk factor for diabetes-related lower-extremity complications. Diffuse frequently encountered pattern neurological dysfunction presents clinically as distal symmetrical sensorimotor polyneuropathy. Due to increasing public health significance its complications, screening diabetic peripheral essential. Consequently, review principles that guide practices, especially in resource-limited clinical settings, urgently needed. Main body Numerous evidence-based assessments are used detect neuropathy. In accordance with current guideline recommendations from American Diabetes Association, International Federation, Working Group on Foot, National Institute Health Care Excellence, algorithm based multiphasic assessment, stratification according developing foot syndrome, individualized treatment, scheduled follow-up suggested use settings. Conclusions Screening settings requires practical comprehensive approach order promptly identify affected individuals. The are: approach, stratification, follow-up. Regular disease using simple may improve patient outcomes.

Language: Английский

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Time to diabetic neuropathy and its predictors among adult type 2 diabetes mellitus patients in Amhara regional state Comprehensive Specialized Hospitals, Northwest Ethiopia, 2022: A retrospective follow up study

PLoS ONE, Journal Year: 2023, Volume and Issue: 18(4), P. e0284568 - e0284568

Published: April 28, 2023

Diabetic neuropathy is the primary cause of foot ulcers and amputations in both industrialized poor countries. In spite this, most epidemiological research on diabetic Ethiopia have only made an effort to estimate prevalence, information underlying condition's beginning not well-established. Therefore, determining time its variables among adult patients with type 2 diabetes mellitus at Compressive Specialized Hospitals Amhara region was aim this study.

Language: Английский

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Morphometry of the sural nerve in diabetic neuropathy: a systematic review

Journal of Ultrasound, Journal Year: 2024, Volume and Issue: 27(2), P. 225 - 239

Published: March 8, 2024

The aim of this systematic review is to evaluate the usefulness sural nerve ultrasonography in diagnosing diabetes mellitus (DM) and diabetic polyneuropathy (DPN), latter which a common long-term complication for patients that frequently involves nerve.

Language: Английский

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Factors associated with severity and anatomical distribution of diabetic foot ulcer in Uganda: a multicenter cross-sectional study

BMC Public Health, Journal Year: 2023, Volume and Issue: 23(1)

Published: March 10, 2023

Abstract Background Diabetic foot ulcer (DFU) is a devastating complication of diabetes mellitus (DM) that associated with increased mortality, morbidity, amputation rate and economic burden. This study aimed at identifying the anatomical distribution factors severity DFU in Uganda. Methodology was multicenter cross-sectional conducted seven selected referral hospitals A total 117 patients were enrolled this between November 2021 January 2022. Descriptive analysis modified Poisson regression performed 95% confidence interval; p-value < 0.2 bivariate considered for multivariate analysis. Results The right affected 47.9% (n = 56) patients, 44.4% 52) had on plantar region an > 5 cm diameter. majority (50.4%, n 59) one ulcer. 59.8% 69) severe DFU, 61.5% 72) female 76.9% uncontrolled blood sugar. mean age years 57.5 (standard deviation 15.2 years). Primary (p 0.011) secondary 0.001) school educational levels, moderate 0.003) visual loss 0.011), 2 ulcers eating vegetables regularly protective against developing 0.03). Severity 3.4 2.7 times more prevalent mild neuropathies 0.01), respectively. Also, 1.5 2.5 higher 5–10 0.047) those 10 diameter 0.002), Conclusion Most located foot. location not severity. Neuropathies but primary education level protective. Early management precipitating important to reduce burden DFU.

Language: Английский

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Endocan expression and correlation with other endothelial determinants in developing a score for early identification of diabetic peripheral neuropathy

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 5, 2025

Diabetic peripheral neuropathy is a common complication of diabetes mellitus that has dire outcomes, affecting the economic profile country. Despite multifactorial background pathogenesis this disease, mechanism underlying still unclear. Endothelial damage new determinant pathogenesis, with endocan as potential biomarker for endothelial dysfunction in diabetic patients. In cross-sectional study, 49 patients and 48 without neuropathy, biomarkers such endocan, hs-CRP, vitamin D, lipid profiles were measured analyzed both groups. The standardized scores dyslipidemia, inflammation, D calculated. All these significantly altered A strong correlation between levels hs-CRP was detected. inflammatory score combined including all above might help early stratification who are at greater risk developing neuropathy.

Language: Английский

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TangBi Formula for Painful Diabetic Distal Symmetric Polyneuropathy: A Multicenter, Randomized, Double‐Blind, Placebo‐Controlled and Parallel‐Group Trial

Journal of Diabetes, Journal Year: 2025, Volume and Issue: 17(1)

Published: Jan. 1, 2025

To determine whether the use of herbal medicines combined with conventional treatment is more effective than medication alone in improving clinical symptoms patients diabetic distal symmetric polyneuropathy (DSPN).

Language: Английский

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