Adult sex change leads to extensive forebrain reorganization in clownfish DOI Creative Commons
Coltan G. Parker, George W. Gruenhagen,

Brianna E. Hegarty

et al.

Biology of Sex Differences, Journal Year: 2024, Volume and Issue: 15(1)

Published: July 23, 2024

Abstract Background Sexual differentiation of the brain occurs in all major vertebrate lineages but is not well understood at a molecular and cellular level. Unlike most vertebrates, sex-changing fishes have remarkable ability to change reproductive sex during adulthood response social stimuli, offering unique opportunity understand mechanisms by which nervous system can initiate coordinate sexual differentiation. Methods This study explores forebrain using single nucleus RNA-sequencing anemonefish Amphiprion ocellaris , producing first atlas brain. Results We uncover extensive differences cell type-specific gene expression, relative proportions cells, baseline neuronal excitation, predicted inter-neuronal communication. Additionally, we identify cholecystokinin, galanin, estrogen systems as central axes Supported these findings, propose model conserved decision-making network spanning multiple subtypes neurons glia, including subpopulations within preoptic area that are positioned regulate gonadal Conclusions work deepens our understanding defines rich suite pathways differentiate adult anemonefish.

Language: Английский

Male-specific vasotocin expression in the medaka tuberal hypothalamus: androgen dependence and probable role in aggression DOI Open Access
Yukika Kawabata-Sakata, Shinji Kanda, Kataaki Okubo

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Sept. 13, 2023

Abstract Terrestrial vertebrates have a population of androgen-dependent vasotocin (VT)-expressing neurons in the extended amygdala that are more abundant males and mediate male-typical social behaviors, including aggression. Teleosts lack these but instead novel male-specific VT-expressing tuberal hypothalamus. Here we found medaka vt expression is dependent on post-pubertal gonadal androgens can act to directly stimulate transcription via androgen receptor subtype Ara. Furthermore, administration exogenous VT induced aggression females alterations milieu led correlated changes levels hypothalamic both sexes. However, genetic ablation failed prevent androgen-induced females. Collectively, our results demonstrate marked dependence teleost hypothalamus, although its relevance needs be further validated.

Language: Английский

Citations

1
Neuroendocrine effects of polychlorinated biphenyls (PCBs) DOI
Andrea C. Gore, R. Thomas Zoeller, Margarita Currás‐Collazo

et al.

Advances in neurotoxicology, Journal Year: 2023, Volume and Issue: unknown, P. 81 - 135

Published: Jan. 1, 2023

Language: Английский

Citations

1
Adult sex change leads to extensive forebrain reorganization in clownfish DOI Creative Commons
Coltan G. Parker, George W. Gruenhagen,

Brianna E. Hegarty

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 30, 2024

Sexual differentiation of the brain occurs in all major vertebrate lineages but is not well understood at a molecular and cellular level. Unlike most vertebrates, sex-changing fishes have remarkable ability to change reproductive sex during adulthood response social stimuli, offering unique opportunity understand mechanisms by which nervous system can initiate coordinate sexual differentiation. This study explores forebrain using single nucleus RNA-sequencing anemonefish

Language: Английский

Citations

0
Genetic adaptations for the oceanic success of fish eggs DOI Creative Commons
Roderick Nigel Finn, Joan Cerdà

Trends in Genetics, Journal Year: 2024, Volume and Issue: 40(6), P. 540 - 554

Published: Feb. 23, 2024

Genetic adaptations of organisms living in extreme environments are fundamental to our understanding where life can evolve. Water is the single limiting parameter this regard, yet when released oceans, single-celled eggs marine bony fishes (teleosts) have no means acquiring it. They strongly hyposmotic seawater and lack osmoregulatory systems. Paradoxically, modern teleosts successfully release vast quantities saline environment recorded most explosive radiation vertebrate history. Here, we highlight key genetic that evolved solve paradox by filling pre-ovulated with water. The degree water acquisition uniquely prevalent teleosts, permitting survival oceanic dispersal their eggs.

Language: Английский

Citations

0
Adult sex change leads to extensive forebrain reorganization in clownfish DOI Creative Commons
Coltan G. Parker, George W. Gruenhagen,

Brianna E. Hegarty

et al.

Biology of Sex Differences, Journal Year: 2024, Volume and Issue: 15(1)

Published: July 23, 2024

Abstract Background Sexual differentiation of the brain occurs in all major vertebrate lineages but is not well understood at a molecular and cellular level. Unlike most vertebrates, sex-changing fishes have remarkable ability to change reproductive sex during adulthood response social stimuli, offering unique opportunity understand mechanisms by which nervous system can initiate coordinate sexual differentiation. Methods This study explores forebrain using single nucleus RNA-sequencing anemonefish Amphiprion ocellaris , producing first atlas brain. Results We uncover extensive differences cell type-specific gene expression, relative proportions cells, baseline neuronal excitation, predicted inter-neuronal communication. Additionally, we identify cholecystokinin, galanin, estrogen systems as central axes Supported these findings, propose model conserved decision-making network spanning multiple subtypes neurons glia, including subpopulations within preoptic area that are positioned regulate gonadal Conclusions work deepens our understanding defines rich suite pathways differentiate adult anemonefish.

Language: Английский

Citations

0