Clinical Spectrum of Long COVID: Effects on Female Reproductive Health

Viruses, Journal Year: 2024, Volume and Issue: 16(7), P. 1142 - 1142

Published: July 16, 2024

The COVID-19 pandemic caused by SARS-CoV-2 has presented numerous health challenges, including long-term COVID, which affects female reproductive health. This review consolidates the current research on impact of menstrual cycle, ovarian function, fertility, and overall gynecological study emphasizes role angiotensin-converting enzyme receptors in viral entry subsequent tissue-specific pathological effects. It also explores potential influence long COVID hormonal balance immune responses, contributing to irregularities impaired function. findings indicate a higher prevalence among women, highlighting substantial implications for need sex-sensitive longitudinal studies. Enhanced surveillance targeted are essential develop effective interventions that prioritize women's well-being following infection. advocates sex-informed approach ongoing healthcare strategies, aiming provide up-to-date pertinent data providers general public, ultimately improving outcomes females affected COVID.

Language: Английский

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Clinical and epidemiological insights into early puberty in Thai girls: a 5-year study

Annals of Pediatric Endocrinology & Metabolism, Journal Year: 2025, Volume and Issue: 30(1), P. 17 - 24

Published: Feb. 26, 2025

There is growing global concern about the shift to earlier onset of puberty among girls; however, prevalences precocious and normal variant Thai girls are uncertain. We conducted a study at King Chulalongkorn Memorial Hospital in Bangkok from 2018 2022 (amid coronavirus disease 2019 pandemic) investigate prevalence, characteristics, treatment early large cohort girls. The medical records 583 who had been evaluated for were reviewed. Demographic clinical approaches analyzed. analyses found significant annual increase evaluations signs (P-value trend 0.04). majority (71.2%) cases categorized as gonadotropin-releasing-hormone (GnRH)-dependent or central (CPP), with 16 showing abnormal brain magnetic resonance imaging findings. Among puberty, was most common category (10.5%), followed by premature thelarche (9.5%), slow-progressive (6.6%), adrenarche (2.2%). Median age presentation, basal luteinizing hormone (LH) follicle-stimulating (FSH), bone differed significantly groups. Importantly, 97% CPP received GnRH agonists. Girls exhibited higher body mass index z-scores LH FSH compared those puberty. Our highlighted impact obesity on pubertal timing. findings underscore need preventive weight management country-specific guideline updates enhance healthcare strategies young

Language: Английский

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Growing Up in the Pandemic: Examining Associations Between Reproductive Development and Depressive Symptoms in Pre- and Pandemic Girls

Research on Child and Adolescent Psychopathology, Journal Year: 2025, Volume and Issue: unknown

Published: April 24, 2025

Language: Английский

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Research summary, possible mechanisms and perspectives of gut microbiota changes causing precocious puberty

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: April 25, 2025

The increasing global incidence of precocious puberty, linked to environmental, metabolic, and genetic factors, necessitates innovative therapies beyond gonadotropin-releasing hormone (GnRH) analogs. Accumulating evidence implicates gut microbiota dysbiosis as a pivotal regulator pubertal timing via interactions with metabolism (e.g., estrogen reactivation β -glucuronidase), neuroendocrine pathways (nitric oxide signaling), immune-inflammatory responses. This review delineates taxonomic alterations in central puberty (CPP) obesity-related subtypes, including Streptococcus enrichment Alistipes depletion, alongside functional shifts microbial metabolite production. Mechanistic insights highlight microbiota-driven modulation the hypothalamic–pituitary-gonadal (HPG) axis, leptin/insulin dynamics, epigenetic regulation. Emerging interventions-probiotics, fecal transplantation (FMT), dietary modifications-demonstrate efficacy preclinical models early clinical studies for delaying onset restoring hormonal balance. Translational efforts validate these strategies are critical addressing psychosocial challenges posed by positioning novel therapeutic frontier pediatric endocrinology.

Language: Английский

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Central precocious puberty in boys: secular trend and clinical features

European Journal of Endocrinology, Journal Year: 2024, Volume and Issue: 190(3), P. 211 - 219

Published: March 1, 2024

Abstract Objective Recent studies suggest that boys enter puberty at a younger age, and the incidence of male central precocious (CPP) is increasing. In this study, we explore CPP identify key clinical auxological indicators for organic (OCPP). Design A retrospective registry-based study. Methods The medical records 43 treated with Helsinki University Hospital between 1985 2014 were reviewed. Clinical, auxological, endocrine data patients included in analyses. Results Based on brain MRI, 26% had OCPP. Between 2010 2014, was 0.34 per 10 000 (95% CI 0.20-0.60). 1990 increased (incidence rate ratio [IRR] 1.10, P = .001). This increase driven by rising idiopathic (ICPP) (IRR 1.11, 95% 1.05-1.19, < .001), while OCPP remained stable (P .41). Compared ICPP, .006), shorter .003), higher basal serum testosterone levels .038). Combining 2 to 4 these readily available cues resulted good excellent (all, area under curve 0.84-0.97, .001) overall performance, differentiating etiology from idiopathic. Conclusions estimated 000, cases associated intracranial pathology. ICPP rates. Patients characterized stature, levels, providing valuable differentiation addition MRI. Utilizing multiple could guide diagnostic decision-making.

Language: Английский

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Endocrinological Involvement in Children and Adolescents Affected by COVID-19: A Narrative Review

Journal of Clinical Medicine, Journal Year: 2023, Volume and Issue: 12(16), P. 5248 - 5248

Published: Aug. 11, 2023

Since the advent of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, an increased incidence several endocrinological anomalies in acute-phase and/or long-term complications has been described. The aim this review is to provide a broad overview available literature regarding changes worldwide epidemiology involvement children since December 2019 and report evidence supporting its association with disease (COVID-19). Although little known endocrine organs during COVID-19 children, current adults epidemiological studies on pediatric population suggest presence causal between virus endocrinopathies. Untreated transient thyroid dysfunction, sick euthyroid syndrome, nonthyroidal illness hypothalamic-pituitary-adrenal (HPA) axis central precocious puberty have observed infection multisystem inflammatory development. Furthermore, higher frequency ketoacidosis at onset new diagnosis type 1 diabetes reported literature. direct not confirmed yet, data development different endocrinopathies both as result complications, reported. This information primary importance guide management patients previous or COVID-19.

Language: Английский

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Characterization of Puberty in an Australian Population-Based Cohort Study

Journal of Adolescent Health, Journal Year: 2023, Volume and Issue: 74(4), P. 665 - 673

Published: Oct. 9, 2023

Abstract

Purpose

Current knowledge of the characteristics puberty beyond age at menarche and thelarche is limited, particularly within population-based cohorts. Secular trends concerns health effects early reinforce value contemporary studies characterizing timing, tempo, duration, synchronicity puberty.

Methods

The Childhood to Adolescence Transition Study a unique Australian cohort individuals followed annually from late childhood adolescence, with up eight assessments pubertal stage 9 19 years (N = 1,183; 636 females). At each assessment, females reported their Tanner Stage breast pubic hair development, while males on genital/pubic development. Nonlinear mixed-effects models characterized trajectories were used derive individual's estimates synchronicity. Parametric survival estimate overall duration

Results

Timing mid-puberty (Tanner 3) ranged 12.5 13.5 years, developing approximately 6 months before males. Pubertal tempo (at mid-puberty) was similar across sex (between half one per year), but slightly shorter in Most exhibited asynchronous changes

Discussion

Estimates timing are consistent reports cohorts two or more decades ago, suggesting stabilization certain predominantly White populations. However, our understanding individual differences (e.g., physical changes) remains limited.

Language: Английский

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Clinical Management and Therapy of Precocious Puberty in the Sapienza University Pediatrics Hospital of Rome, Italy

Children, Journal Year: 2023, Volume and Issue: 10(10), P. 1672 - 1672

Published: Oct. 10, 2023

Puberty identifies the transition from childhood to adulthood. Precocious puberty is onset of signs pubertal development before age eight in girls and nine boys, it has an incidence 1/5000–1/10,000 with F:M ratio ranging 3:1 20:1. can be divided into central, also known as gonadotropin-dependent precocious or true puberty, peripheral, recognized gonadotropin-independent pseudopuberty. Thus, main aim this narrative report describe standard clinical management therapy according experience expertise pediatricians pediatric endocrinologists at Policlinico Umberto I, Sapienza University Rome, Italy. In suspicion early sexual maturation, important collect information regarding onset, speed maturation secondary features, exposure exogenous sex steroids presence neurological symptoms. The objective examination, addition evaluation characteristics, must include auxological parameters. Initial laboratory investigations should serum gonadotropin levels (LH FSH) steroids. Brain MRI performed indicated by 2009 Consensus Statement all boys regardless chronological 6 years age. gold treatment central represented GnRH analogs, whereas, far peripheral forms are concerned, triggering cause identified treated. At moment there no reliable data establishing criteria for discontinuation analog therapy. However, numerous pieces evidence suggest that suspended physiological which occurs.

Language: Английский

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Screening for central precocious puberty by single basal Luteinizing Hormone levels

Endocrine, Journal Year: 2024, Volume and Issue: 85(2), P. 955 - 963

Published: March 20, 2024

Abstract Purpose To identify cut-off for basal LH levels and pelvic ultrasound uterine ovarian parameters indicating an Hypotalamic–Pituitary–Gonadal (HPG) axis activation as diagnostic of Central Precocious Puberty (CPP). Methods 248 girls referred suspected precocious/early puberty who had undergone a GnRH stimulation test were enrolled divided into three groups: Premature Idiopathic Thelarche (PIT), CPP, Early (EA). For every patient serum Luteinising Hormone (LH) Follicle Stimulating (FSH), LH/FSH ratio ultrasonographic also collected. Through the use Receiver Operating Curves (ROCs) sensitivity (Se) specificity (Sp) LH, FSH, evaluated at each level Area Under Curve (AUC) was measured. Results Basal model ≥0.14 mIU/mL reached highest predictability (90.6% 78.2%, Se Sp, respectively). ≥0.1 showed 85.90% 78.14%, while FSH (≥2.36 mIU/mL) lowest predictability, with less favourable (71%) (70.5%). Cut-off point length 35 mm, (83.5% 42.9% respectively) calculated. volumes, ROC curves very low specificity. Conclusion A single measurement under limit may be adequate to exclude HPG CPP.

Language: Английский

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Spatial distribution and determinants of Early sexual initiation in Ethiopia

BMC Public Health, Journal Year: 2024, Volume and Issue: 24(1)

Published: June 7, 2024

Early sexual initiation has negative health, social, and economic consequences for both women future generations. The trend of early is increasing globally, leading to higher rates sexually transmitted diseases unplanned pregnancies. Ethiopia been challenged various disasters that makes vulnerable position them at heightened risk in the last four years. spatial patterns factors post-conflict-post pandemic settings not well understood. Hence this research aimed mapping Spatial Patterns identifying determinant Post-COVID-Post-Conflict Settings.

Language: Английский

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