Genetically Determined Plasma Docosahexaenoic Acid Showed a Causal Association with Female Reproductive Longevity-Related Phenotype: A Mendelian Randomization Study DOI Open Access
Huajing Gao, Yibin Ying, Jing Sun

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(23), P. 4103 - 4103

Published: Nov. 28, 2024

Background: Female reproductive aging remains irreversible. More evidence is needed on how polyunsaturated fatty acids (PUFAs) affect the female lifespan. Objectives: To identify and validate specific PUFAs that can influence timing of menarche menopause in women. Methods: We utilized a two-sample Mendelian randomization (MR) framework to evaluate causal relationships between various longevity, defined by age at (AAM) natural (ANM). Our analyses leveraged summary statistics from four genome-wide association studies (GWASs) plasma concentrations 10 PUFAs, including 8866 121,633 European individuals 1361 East Asian individuals. Large-scale GWASs for traits provided genetic data AAM ANM over 202,323 females 43,861 females. Causal effects were estimated beta coefficients, representing, each increase standard deviation (SD) PUFA concentration, yearly or ANM. Replications, meta-analyses, cross-ancestry assessed inference. Conclusions: Higher DHA was identified be associated with delayed without affecting menarche, offering potential intervention target extending longevity.

Language: Английский

The Effect of the COVID-19 Pandemic on Precocious Puberty DOI Open Access
Mojdeh Banaei, Fatemeh Darsareh, Nasibeh Roozbeh

et al.

Galen Medical Journal, Journal Year: 2024, Volume and Issue: 13, P. e3112 - e3112

Published: March 11, 2024

-

Citations

0
Impactul alimentaţiei asupra instalării pubertăţii precoce DOI

Heidrun Adu­mi­­trăchioaiei,

Alina Filip

Pediatru ro, Journal Year: 2024, Volume and Issue: 2(74), P. 18 - 18

Published: Jan. 1, 2024

Citations

0
Central Precocious Puberty During the COVID-19 Pandemic Period: A Systematic Review of Literature DOI Open Access

Maria Fanaki,

Lina Michala,

Ervin Nazari

et al.

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 7, 2024

Central precocious puberty (CPP) is a condition where the hypothalamus-pituitary-gonadal axis activated earlier than normal, leading to premature development of secondary sexual characteristics before eight years age in girls and nine boys. The purpose this study was critically systematically evaluate literature regarding CPP rise during COVID-19 pandemic. We searched PubMed Google Scholar for relevant articles using following MeSH terms: "COVID-19, "precocious puberty," "early "pediatric endocrinology," "pandemic effects." included studies calculating risk excluded looking at patients with an identifiable cause or peripheral puberty. primary outcome prevalence central pandemic compared pre-pandemic period. analyzed data anthropometric, biochemical, pelvic ultrasound between two groups. Overall, 16 2.175 subjects were included, which 1.818 diagnosed CPP. There number new diagnoses (985 subjects) period (833 subjects). mean diagnosis first group 7.42 versus 7.54 second group. Notably, associated higher body mass index (BMI) (17.50 17.08). lockdowns led changes lifestyle habits, social isolation, sleep disturbance, excess screen time, increased stress levels. hypothesize that these alterations influenced increase frequency.

Language: Английский

Citations

0
Comparison of central precocious puberty frequency before and during COVID-19: a systematic review and meta-analysis DOI Creative Commons
Jianwei Zhang,

Jinliang Xu,

Xiaoli Tang

et al.

BMC Endocrine Disorders, Journal Year: 2024, Volume and Issue: 24(1)

Published: Oct. 17, 2024

The current systematic review and meta-analysis assessed the prevalence of central precocious puberty (CPP) throughout novel coronavirus disease 2019 (COVID-19) pandemic.

Language: Английский

Citations

0
Genetically Determined Plasma Docosahexaenoic Acid Showed a Causal Association with Female Reproductive Longevity-Related Phenotype: A Mendelian Randomization Study DOI Open Access
Huajing Gao, Yibin Ying, Jing Sun

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(23), P. 4103 - 4103

Published: Nov. 28, 2024

Background: Female reproductive aging remains irreversible. More evidence is needed on how polyunsaturated fatty acids (PUFAs) affect the female lifespan. Objectives: To identify and validate specific PUFAs that can influence timing of menarche menopause in women. Methods: We utilized a two-sample Mendelian randomization (MR) framework to evaluate causal relationships between various longevity, defined by age at (AAM) natural (ANM). Our analyses leveraged summary statistics from four genome-wide association studies (GWASs) plasma concentrations 10 PUFAs, including 8866 121,633 European individuals 1361 East Asian individuals. Large-scale GWASs for traits provided genetic data AAM ANM over 202,323 females 43,861 females. Causal effects were estimated beta coefficients, representing, each increase standard deviation (SD) PUFA concentration, yearly or ANM. Replications, meta-analyses, cross-ancestry assessed inference. Conclusions: Higher DHA was identified be associated with delayed without affecting menarche, offering potential intervention target extending longevity.

Language: Английский

Citations

0