Unveiling follicular thyroid carcinoma by solitary spinal metastasis causing severe neurological deficit in a 67-year-old female: A case report DOI Open Access
Yumna Njoum, Lila H. Abu-Hilal, Duha I. Barghouthi

et al.

International Journal of Surgery Case Reports, Journal Year: 2023, Volume and Issue: 109, P. 108541 - 108541

Published: July 21, 2023

Follicular thyroid carcinoma (FTC) exhibits the ability to metastasize hematogenously distant organs. Spinal metastasis is an unusual site for that even when it does, spinal manifests late in course of disease and frequently linked advanced a bad prognosis. Until 2019, literature only showed 29 cases FTC with as first presenting feature.We present case 67-year-old female who presented acute onset severe neurological deficit ended up bedridden. Magnetic resonance imaging spine revealed lesion causing cord compression. Urgent surgical decompression was performed, histopathology confirmed metastatic FTC. Subsequent comprehensive evaluation, unveiled primary tumor.FTC accounts 1 % all malignancies, Therefore, regardless how irrelevant symptoms may appear at first, important understand risk factors, screening recommendations, diagnostic techniques, treatment, vast range potential symptoms. Just like our patient, had incontinence abrupt loss motor sensory function her lower limbs be diagnosed compression by FTC.This instance emphasizes crucial consider possible differential diagnosis metastasis, there no known cancer. Prompt diagnosis, staging, multidisciplinary management are optimizing outcomes.

Language: Английский

Prognosis and influencing factors of follicular thyroid cancer DOI Creative Commons
Jiafei Shen,

Meiying Yan,

Long Chen

et al.

Cancer Medicine, Journal Year: 2023, Volume and Issue: 13(1)

Published: Dec. 16, 2023

Follicular thyroid cancer (FTC) is prone to distant metastasis, and patients with metastasis often have poor prognosis. In this study, the impact of other relevant factors on prognosis follicular carcinoma was examined.

Language: Английский

Citations

3
Neck Surgery for Non-Well Differentiated Thyroid Malignancies: Variations in Strategy According to Histopathology DOI Open Access
Fernando López, Abir Al Ghuzlan, Mark Zafereo

et al.

Cancers, Journal Year: 2023, Volume and Issue: 15(4), P. 1255 - 1255

Published: Feb. 16, 2023

Lymph node metastases in non-well differentiated thyroid cancer (non-WDTC) are common, both the central compartment (levels VI and VII) lateral neck (Levels II to V). Nodal negatively affect prognosis should be treated maximize locoregional control while minimizing morbidity. In non-WDTC, rate of nodal involvement is variable depends on histology tumor. For medullary carcinomas, poorly anaplastic high frequency lymph makes dissection generally necessary. mucoepidermoid malignant peripheral nerve sheath tumors, sarcomas, teratomas or thyroblastomas, less often necessary, as clinical lymphnode common. We aim summarize medical literature opinions several experts from different parts world current philosophy for managing common types cancer.

Language: Английский

Citations

2
The association between the interval of radioiodine treatment and treatment response, and side effects in patients with lung metastases from differentiated thyroid cancer DOI Creative Commons
Hongxi Wang, Lei Shi, Rui Huang

et al.

Frontiers in Endocrinology, Journal Year: 2023, Volume and Issue: 14

Published: May 31, 2023

Objective Repeat radioiodine (RAI) treatment has been widely implemented for RAI-avid lung metastases and is clinically effective metastatic differentiated thyroid cancer (DTC). We aim to investigate the association between interval of RAI short-term response, side effects in patients with from DTC identify predictors non-effective response next treatment. Methods A total 282 course pairs 91 were established categorized into two groups by neighboring (<12 ≥12 months), characteristics compared. Multivariate logistic regression was used associated response. The former latter compared while taking account interval. Results No significant difference found (p > 0.05). In multivariate analysis, age ≥ 55 years (OR = 7.29, 95% CI 1.66–33.35, p 0.008), follicular 5.00, 1.23–22.18, 0.027), a second as 4.77, 1.42–18.61, 0.016) significantly There no courses Conclusion does not affect metastases. It feasible defer repeat evaluation an at least 12 months obtain reduce risk effects.

Language: Английский

Citations

2
Outcomes of Patients With Metastatic Differentiated Thyroid Cancer After Excellent Response to Treatment DOI Creative Commons
Chia‐Jung Hsu, Kun‐Yu Lai, Yuling Lu

et al.

Frontiers in Endocrinology, Journal Year: 2022, Volume and Issue: 13

Published: June 28, 2022

Background To evaluate the outcomes in differentiated thyroid cancer (DTC) patients who achieved excellent response to initial treatment and developed distant metastasis during follow-up. Methods Thyroid registered Chang Gung Memorial Hospital database between January 1979 December 2019 were assessed. Results Among 1053 DTC with therapy, 14 (1.3%) metastatic disease follow-up, including 6 males 8 females median age of 50.2 years [interquartile range (IQR), 39.9-53.7]. Nine (64.3%) had papillary cancer, four (28.6%) follicular one (7.1%) Hürthle cell cancer. Most (92.9%) stage I at diagnosis. The sites lung (71.4%), bone (7.1%), mediastinum multiple (14.3%). With a follow-up 18.3 (IQR, 14.8-23.8), 2 disease-specific mortality. 5- 10-year survival after diagnosis was 92% 74%, respectively. Multiple associated increased risk mortality (P = 0.022). Conclusions A small proportion an excellence therapy organ metastases conferred worse survival.

Language: Английский

Citations

3
Long-term Outcome of Follicular Thyroid Carcinoma: A Retrospective Cohort Study on 10-year Outcome of Follicular Thyroid Carcinoma DOI Open Access

Sidhu R Sekhar,

Revathy Ajayachandran K Nair,

Misha J. C. Babu

et al.

World Journal of Endocrine Surgery, Journal Year: 2024, Volume and Issue: 15(3), P. 71 - 75

Published: April 20, 2024

Language: Английский

Citations

0
Impact of distant metastasis on overall survival and cancer specific survival of elderly patients with differentiated thyroid cancer DOI Creative Commons

Chen Shu-qian,

Lizhen Xu,

Shuyao Pan

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Oct. 22, 2024

Distant metastases are common in most elderly patients, because patients diagnosed with advanced thyroid cancer due to delayed diagnosis. There is still few specific real-world data regarding prognosis the differentiated (DTC). The purpose of this study evaluate prognostic factors and survival rate DTC metastasis. This retrospective included 14,603 from 2010 2015, including 447 distant metastasis via Surveillance, Epidemiology End Results (SEER) database. overall (OS) cancer-specific (CSS) or non-metastasis were determined by univariate multivariate analysis. Age, primary site operation, radiotherapy, chemotherapy tumor size associated OS CSS Compared without surgery, total thyroidectomy showed significantly better OS. For radiotherapy was improving CSS. Chemotherapy increased risk death. early identification metastasis, prognosis.

Language: Английский

Citations

0
A Rare Case of Functional Metastatic Follicular Thyroid Carcinoma With Concomitant Thyrotoxicosis DOI Creative Commons

Yun Ann Chin,

Sumbul Zaheer,

Yi Lin Teh

et al.

Case Reports in Endocrinology, Journal Year: 2024, Volume and Issue: 2024(1)

Published: Jan. 1, 2024

We report a case of 60‐year‐old lady with metastatic follicular thyroid carcinoma (FTC) who was presented thyrotoxicosis and heart failure symptoms after total thyroidectomy. Clinical features investigations led to the diagnosis functional FTC concomitant thyrotoxicosis. Levothyroxine therapy stopped, she treated propylthiouracil (PTU) followed by serial radioiodine treatments (RAITs) good control metastases. Despite having very high disease burden FTC, has been able maintain her status thus far, 4.5 years initial diagnosis.

Language: Английский

Citations

0
Metástasis de carcinoma folicular de tiroides en el axis DOI

José Luis Alcocer Maldonado,

Luis Gerardo Domínguez Carrillo

Acta Médica Grupo Ángeles, Journal Year: 2024, Volume and Issue: 22(5), P. 399 - 400

Published: Jan. 1, 2024

Citations

0
Atypical Femur Fracture Unmasking Follicular Thyroid Cancer in a 54-year-old Woman DOI Creative Commons

Jennifer S. Hatfield,

Peter N. Bonneau,

Mohamed K M Shakir

et al.

AACE Clinical Case Reports, Journal Year: 2023, Volume and Issue: 9(6), P. 213 - 215

Published: Aug. 3, 2023

A 54-year-old woman presented to the endocrinology clinic after sustaining an atypical fracture her left lesser trochanter. She was sitting in car driveway when husband unintentionally surprised by appearing window. pushed forcefully on brake pedal and felt a crack. had immediate severe pain hip area. went emergency room where x-ray done (Figure 1). Hip MRI showed hyperintense intertrochanteric soft tissue mass of 2) biopsy this revealed crowding, elongated/enlarged nuclei, nuclear grooves, scattered intranuclear pseudoinclusions 3). Her medical history significant for 5.2-cm thyroid follicular adenoma removed 2014, gastric acid reflux. Patient reports little no with ambulation night symptoms. Physical examination unremarkable normal gait, joint/muscle tenderness, range motion.Fig 2MRI femur showing signal intensity near trochanter cortical disruption.View Large Image Figure ViewerDownload Hi-res image Download (PPT)Fig 3High power H&E highlighting features PTC including cytologic pseudoinclusions.View (PPT) FTC is second most common cancer known metastasize hematogenously rather than through lymphatic system which could explain its more spread1Wu M-H, Lee Y-Y, Lu Y-L Lin S-F (2022) Risk Factors Prognosis Metastatic Follicular Thyroid Cancer. Front. Endocrinol. 13:791826Google Scholar. usually presents distant metastasis local metastasis. The incidence approximately 6-20% bones lungs being sites2Omar, Berrada, Hammouda Yassir, Oukessou Youssef, Rouadi Sami, Abada Redalah Larbi, Roubal Mohamed, Mahtar Mohamed rare case carcinoma sacral region: report literature review. International Journal Surgery Case Reports 94:107001.Google Outcomes patients metastatic are poor, 10-year survival 41% among those disease at time diagnosis3Ashorobi, Damilola, Peter Lopez (2021) Cancer Stat pearls NCBI BookShelf. StatPearls. Publishing: 2022Google This patient further evaluated undergoing bone lesion that FTC. On ultrasound she two nodules remaining gland (0.9cm isthmus nodule 0.7cm right lower nodule). Both were biopsied suspicious malignancy, but benign. underwent completion thyroidectomy bilateral central neck dissection pathology 0.6cm papillary cancer-follicular variant negative lymph nodes. histology from initial surgery 2014 reviewed confirmed adenoma. Imaging studies prior treatment I131 also parietal lung nodules. therapy intravenous zoledronic without prophylactic fixation. serum thyroglobulin level has decreased remains detectable. highlights importance thorough investigation because may lead early diagnosis appropriate management cancer.

Language: Английский

Citations

1
Radioactive iodine therapy for follicular thyroid cancer: a 15 years follow-up study of Chinese patients DOI Creative Commons
He Shi, Yang Bo,

Jian-Iin Feng

et al.

Nuclear Medicine Communications, Journal Year: 2023, Volume and Issue: 45(3), P. 169 - 174

Published: Dec. 14, 2023

Purpose To identify long-term predictors of distant metastases (DM) and the overall survival (OS) follicular thyroid cancer (FTC) patients who underwent radioactive iodine (RAI) therapy. And to expand knowledge about clinical course experience RAI treatment for FTC. Materials A total 117 FTC therapy at our institution from 2005 2020 were retrospectively studied. Patient characteristics, serum stimulating thyroglobulin (sTg) antibody levels, process follow-up data collected until 26 April 2022. Results 16 (13.7%) lost follow-up. 23 (19.7%) with DM died all without still alive. was seen in 58.4% (59/101) patients. The most common location metastatic lesions lung. Then bone. mean time 156 months [95% confidence interval (CI): 142–171]. Five-year 10-year cumulative rates them 88.8% 67.4%, respectively. As 80.4% 41.3%, Age diagnosis [odds ratio (OR) = 1.080, P 0.009], sessions (OR 2.959, 0.001) sTg level 1.006, 0.002) predictive occurrence RAI. In group DM, analysis showed that males more likely have a lower OS than females ( 0.039). Conclusion Age, number sessions, Sex would influence DM.

Language: Английский

Citations

1