Exploring the association between exposure to pesticides, polycyclic aromatic hydrocarbons, and phthalates and Metabolic Syndrome in NHANES, 2007-2012: utilizing a multi-step statistical strategy DOI Creative Commons
Yadan Xu, Yifan Xu, Wen Gu

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: July 29, 2024

Abstract Background Pesticides, polycyclic aromatic hydrocarbons (PAHs), and phthalates are recognized as potential contributors to metabolic disorders. Nevertheless, the combined effect of simultaneous exposure these chemicals on MetS remains elusive. Objectives To explore impacts three classes identify critical chemicals. Methods Based NHANES database from 2007–2012, our study included 4,030 non-pregnant individuals aged 20 years or older. We used weighted linear regression model, variable selection models (including LASSO BMA models), well mixture model (WQS model) investigate correlation between MetS. Additionally, stratified analyses were performed based gender age. Results The generalized revealed a positive 2-PHEN with (OR: 1.37, 95% CI: 1.19–1.59, P < 0.001). Both identified significant chemical positively associated WQS showed association overall categories MetS, highest being 2-PHEN, MEOHP 2-NAP, 2,5-DCP. Stratified demonstrated different subgroups in regression, models. Notably, subgroup female (OR = 1.40, 1.08–1.83, 0.05), 2,5-DCP, MEP primary contributions Mets. Conclusion Combined groups was related higher risk PAH group exhibiting most pronounced emerging key consistent robust findings, promoting public health concerns regarding hazards EDCs diseases.

Language: Английский

Estrogen and cardiovascular disease DOI Creative Commons
Felice L Gersh, James H. O’Keefe, Andrew Elagizi

et al.

Progress in Cardiovascular Diseases, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Language: Английский

Citations

31
Neuregulin 4 as a novel adipokine in energy metabolism DOI Creative Commons
Yuanbin Liu, Mingkai Chen

Frontiers in Physiology, Journal Year: 2023, Volume and Issue: 13

Published: Jan. 10, 2023

Adipose tissue has been shown to play a key role in energy metabolism and it regulate metabolic homeostasis through the secretion of adipokines. Neuregulin 4 (Nrg4), novel adipokine secreted mainly by brown adipose (BAT), recently characterized as having an important effect on regulation glucolipid metabolism. Nrg4 can modulate BAT-related thermogenesis increasing sympathetic innervation therefore potential benefits. improves dysregulation various diseases such insulin resistance, obesity, non-alcoholic fatty liver disease, diabetes several mechanisms anti-inflammation, autophagy regulation, pro-angiogenesis, lipid normalization. However, inconsistent findings are found regarding effects clinical settings, this heterogeneity needs be further clarified future studies. The protective suggests that may promising endocrine therapeutic target.

Language: Английский

Citations

25
Unraveling Adipose Tissue Dysfunction: Molecular Mechanisms, Novel Biomarkers, and Therapeutic Targets for Liver Fat Deposition DOI Creative Commons
Marta Lopez‐Yus,

C. Hörndler,

Sofía Borlán

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(5), P. 380 - 380

Published: Feb. 22, 2024

Adipose tissue (AT), once considered a mere fat storage organ, is now recognized as dynamic and complex entity crucial for regulating human physiology, including metabolic processes, energy balance, immune responses. It comprises mainly two types: white adipose (WAT) brown (BAT) thermogenesis, with beige adipocytes demonstrating the plasticity of these cells. WAT, beyond lipid storage, involved in various activities, notably lipogenesis lipolysis, critical maintaining homeostasis. also functions an endocrine secreting adipokines that influence metabolic, inflammatory, processes. However, dysfunction especially related to obesity, leads disturbances, inability properly store excess lipids, resulting ectopic deposition organs like liver, contributing non-alcoholic fatty liver disease (NAFLD). This narrative review delves into multifaceted roles its composition, functions, pathophysiology WAT dysfunction. explores diagnostic approaches adipose-related disorders, emphasizing importance accurately assessing AT distribution understanding relationships between compartments health. Furthermore, it discusses therapeutic strategies, innovative therapeutics adipose-derived mesenchymal stem cells (ADMSCs)-based treatments gene therapy, highlighting potential precision medicine targeting obesity associated complications.

Language: Английский

Citations

14
MASLD: Prevalence, Mechanisms, and Sex-Based Therapies in Postmenopausal Women DOI Creative Commons
Ilaria Milani,

Marianna Chinucci,

Frida Leonetti

et al.

Biomedicines, Journal Year: 2025, Volume and Issue: 13(4), P. 855 - 855

Published: April 2, 2025

Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic influenced by genetic, lifestyle, and environmental factors. While MASLD more prevalent in men, women are at increased risk after menopause, highlighting critical pathogenetic role of sex hormones. The complex interplay between estrogen deficiency, visceral fat accumulation, metabolic syndrome (MetS), inflammation accelerates progression, increases cardiovascular (CV) risk, triggers a cycle worsening adiposity, dysfunction, psychological problems, including eating disorders. Weight loss postmenopausal can significantly improve both outcomes, helping to prevent related conditions. This review examines prevalence MASLD, its comorbidities (type 2 diabetes T2D, CV, mental disorders), mechanisms, pharmacological treatment with GLP-1 receptor agonists (GLP1-RAs), focus on women. Given use GLP1-RAs obesity T2D patients, increase MetS this analyzes potential stable GLP-1–estrogen conjugate as therapeutic approach subgroup. By combining synergistic effects hormones, dual agonist has been shown food intake reward suppression, resulting greater weight improved insulin sensitivity, glucose, lipid metabolism. Therefore, we hypothesize that pharmacotherapy may provide targeted benefits than either hormone alone protecting liver, β-cells, overall health. As these only supported preclinical data, highlights need for future research evaluate confirm mechanisms efficacy clinical settings, particularly

Language: Английский

Citations

1
The role of the thyroid in polycystic ovary syndrome DOI Creative Commons
Huanhuan Fan, Qingling Ren,

Zhejin Sheng

et al.

Frontiers in Endocrinology, Journal Year: 2023, Volume and Issue: 14

Published: Oct. 5, 2023

Polycystic ovary syndrome (PCOS) is the most common endocrine and metabolic disease in women of childbearing age can cause disorder, infertility, increased anxiety depression; as a result, it seriously affect physical mental health fertile women. PCOS highly clinically heterogeneous with unclear etiology pathogenesis, which increases difficulty treatment. The thyroid gland has complex regulatory effects on metabolism, reproduction, emotion, produces hormones that act almost all cells human body. clinical manifestations are similar to some diseases. Furthermore, diseases, such subclinical hypothyroidism (SCH), not only increase incidence rate PCOS, but also exacerbate its associated abnormalities reproductive disorders. Interestingly, However, role remains unclear. This review intended thoroughly explore critical by summarizing comorbidity diseases their combined disorders, related disorders; analyzing potential mechanism through influences development progression symptoms. We hope this will provide valuable reference for PCOS.

Language: Английский

Citations

22
Gut Microbiota and Acylcarnitine Metabolites Connect the Beneficial Association between Estrogen and Lipid Metabolism Disorders in Ovariectomized Mice DOI Creative Commons
Mengmeng Guo,

Xi Cao,

De Ji

et al.

Microbiology Spectrum, Journal Year: 2023, Volume and Issue: 11(3)

Published: May 4, 2023

Our findings establish a role for gut microbes in the progression of estrogen deficiency-induced lipid metabolism disorders and reveal key target bacteria that may have potential to regulate acylcarnitine synthesis. These suggest possible route use or induced by deficiency.

Language: Английский

Citations

11
The methyl-CpG-binding protein 2 (Mecp2) regulates the hypothalamic mitochondrial function and white adipose tissue lipid metabolism DOI
Nuria Llontop,

Cristián Mancilla,

Patricia Ojeda-Provoste

et al.

Life Sciences, Journal Year: 2025, Volume and Issue: unknown, P. 123478 - 123478

Published: Feb. 1, 2025

Language: Английский

Citations

0
Exploring the association between exposure to pesticides, polycyclic aromatic hydrocarbons, and phthalates and metabolic syndrome in National Health and Nutrition Examination Survey in the USA, 2007–2012: utilizing a multi-step statistical strategy DOI Creative Commons
Yadan Xu, Yifan Xu, Wen Gu

et al.

BMC Public Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 14, 2025

Pesticides, polycyclic aromatic hydrocarbons (PAHs), and phthalates are recognized as potential contributors to metabolic disorders. Nevertheless, the combined effect of simultaneous exposure these chemicals on syndrome (MetS) remains elusive. To explore impacts pesticides, PAHs identify critical MetS. Based National Health Nutrition Examination Survey (NHANES) database from 2007—2012, our study included 4030 non-pregnant individuals aged 20 years or older. We used weighted linear regression model, variable selection models (including LASSO BMA models), well a mixture model (WQS model) investigate correlation between Additionally, stratified analyses were performed based gender age. The generalized revealed positive 2-hydroxyphenanthrene (2-PHEN) with MetS (OR: 1.37, 95% CI: 1.19–1.59, P < 0.001). Both identified 2-PHEN significant chemical positively associated WQS showed association overall three categories MetS, highest being 2-PHEN. Stratified demonstrated different subgroups. Notably, in subgroup female (OR = 1.40, 1.08–1.83, 0.05), 2-PHEN, 2,5-dichlorophenol (2,5-DCP), 2-hydroxynaphthalene (2-NAP), mono-ethyl phthalate (MEP) primary contributions Combined groups was an increased risk group exhibiting most pronounced emerging key chemical, underscoring public health concerns regarding risks endocrine-disrupting (EDCs) diseases.

Language: Английский

Citations

0
Thermogenesis and Energy Metabolism in Brown Adipose Tissue in Animals Experiencing Cold Stress DOI Open Access
Xiang Zhang, Xiao Jin, Min Jiang

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 3233 - 3233

Published: March 31, 2025

Cold exposure is a regulatory biological functions in animals. The interaction of thermogenesis and energy metabolism brown adipose tissue (BAT) important for metabolic regulation cold stress. Brown adipocytes (BAs) produce uncoupling protein 1 (UCP1) mitochondria, activating non-shivering (NST) by fuel combustion from ATP production response to stimuli. To elucidate the mechanisms underlying BAT under stress, we explored how triggers activation regulates overall metabolism. First, briefly outline precursor composition function BA. Second, explore roles cAMP- kinase A (PKA) adenosine monophosphate-activated (AMPK) signaling pathways BA during Then, analyze mechanism which mitochondria homeostasis balance This research reveals potential therapeutic targets, such as PKA, AMPK, UCP1 PGC-1α, can be used develop innovative strategies treating diseases. Furthermore, it provides theoretical support optimizing stress strategies, including pharmacological genetic modulation thermogenic pathways, improve livestock.

Language: Английский

Citations

0
Estrogen regulation of the nucleus accumbens as a gateway to understanding menopause associated metabolic dysfunction DOI Creative Commons
Cheryl S. Rosenfeld, Victoria J. Vieira‐Potter

npj Women s Health, Journal Year: 2025, Volume and Issue: 3(1)

Published: April 23, 2025

Language: Английский

Citations

0