Exploring the association between exposure to pesticides, polycyclic aromatic hydrocarbons, and phthalates and Metabolic Syndrome in NHANES, 2007-2012: utilizing a multi-step statistical strategy DOI Creative Commons
Yadan Xu, Yifan Xu, Wen Gu

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: July 29, 2024

Abstract Background Pesticides, polycyclic aromatic hydrocarbons (PAHs), and phthalates are recognized as potential contributors to metabolic disorders. Nevertheless, the combined effect of simultaneous exposure these chemicals on MetS remains elusive. Objectives To explore impacts three classes identify critical chemicals. Methods Based NHANES database from 2007–2012, our study included 4,030 non-pregnant individuals aged 20 years or older. We used weighted linear regression model, variable selection models (including LASSO BMA models), well mixture model (WQS model) investigate correlation between MetS. Additionally, stratified analyses were performed based gender age. Results The generalized revealed a positive 2-PHEN with (OR: 1.37, 95% CI: 1.19–1.59, P < 0.001). Both identified significant chemical positively associated WQS showed association overall categories MetS, highest being 2-PHEN, MEOHP 2-NAP, 2,5-DCP. Stratified demonstrated different subgroups in regression, models. Notably, subgroup female (OR = 1.40, 1.08–1.83, 0.05), 2,5-DCP, MEP primary contributions Mets. Conclusion Combined groups was related higher risk PAH group exhibiting most pronounced emerging key consistent robust findings, promoting public health concerns regarding hazards EDCs diseases.

Language: Английский

Protein-coding mutation inAdcy3increases adiposity and alters emotional behaviors sex-dependently in rats DOI Creative Commons
M.L. Fitzpatrick, Alexandria Szalanczy, Angela Beeson

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: June 16, 2024

has been linked to both obesity and major depressive disorder (MDD). Our lab identified a protein-coding variant in the 2

Language: Английский

Citations

0
Immunisation of the somatostatin gene alters hypothalamic-pituitary-liver gene expressions and enhances growth in Dazu black goats DOI Creative Commons
Ge Qin, Shiyong Fang, Xian-qing Song

et al.

Animal Bioscience, Journal Year: 2024, Volume and Issue: 37(11), P. 1987 - 1999

Published: June 26, 2024

Objective: Somatostatin (SS) plays important regulatory roles in animal growth and reproduction by affecting the synthesis secretion of hormone (GH). However, mechanism which SS regulates development goats is still unclear.Methods: In this study, we randomly selected eight 7-month-old Dazu black (DBGs) similar body weight equally assigned four bucks as immunised negative control groups. The group received Salmonella typhi attenuated vaccine X9241 (ptCS/2SS-asd) orally, whilst empty vector (pVAX-asd) orally.Results: concentration serum was significantly lower than that group, daily gain higher (p<0.05). SS-14 DNA immunisation resulted concentrations growth-related hormones such GH-releasing insulin factor 1 (IGF-1) RNA-seq analysis hypothalamus oral DBGs identified 31 differentially expressed genes (DEGs). Pituitary gland 164 DEGs. A total 246 DEGs were detected liver RNA-seq. Gene ontology enriched mitochondrial envelope, extracellular region, receptor binding cell proliferation. biological metabolic pathways associated with explored Kyoto encyclopedia genomes analysis. pathways, oxidative phosphorylation, vitamin digestion absorption galactose metabolism. These candidate (e.g. DGKK, CYTB, DUSP1, LRAT) may provide references for exploring molecular mechanisms promotes development.Conclusion: Overall, these results demonstrated enhanced altering regulating expression hypothalamic–pituitary–liver axis.

Language: Английский

Citations

0
Biochemical and Histological Effects of Long-Term Administration of Estrogen on Female Mice DOI Open Access
Talal Jabal Hussen, Sattar J. J. AL-Shaeli,

Baidaa H.R. Al-Mahna

et al.

Advances in Animal and Veterinary Sciences, Journal Year: 2024, Volume and Issue: 12(8)

Published: Jan. 1, 2024

Much like the other steroid hormones, estradiol passively diffuses into cell, binds to cytosolic estrogen receptors (ERs) and activates

Language: Английский

Citations

0
Hypothalamic neural circuits regulating energy expenditure DOI
Rashmita Basu, Jonathan N. Flak

Vitamins and hormones, Journal Year: 2024, Volume and Issue: unknown, P. 79 - 124

Published: July 20, 2024

Language: Английский

Citations

0
Exploring the association between exposure to pesticides, polycyclic aromatic hydrocarbons, and phthalates and Metabolic Syndrome in NHANES, 2007-2012: utilizing a multi-step statistical strategy DOI Creative Commons
Yadan Xu, Yifan Xu, Wen Gu

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: July 29, 2024

Abstract Background Pesticides, polycyclic aromatic hydrocarbons (PAHs), and phthalates are recognized as potential contributors to metabolic disorders. Nevertheless, the combined effect of simultaneous exposure these chemicals on MetS remains elusive. Objectives To explore impacts three classes identify critical chemicals. Methods Based NHANES database from 2007–2012, our study included 4,030 non-pregnant individuals aged 20 years or older. We used weighted linear regression model, variable selection models (including LASSO BMA models), well mixture model (WQS model) investigate correlation between MetS. Additionally, stratified analyses were performed based gender age. Results The generalized revealed a positive 2-PHEN with (OR: 1.37, 95% CI: 1.19–1.59, P < 0.001). Both identified significant chemical positively associated WQS showed association overall categories MetS, highest being 2-PHEN, MEOHP 2-NAP, 2,5-DCP. Stratified demonstrated different subgroups in regression, models. Notably, subgroup female (OR = 1.40, 1.08–1.83, 0.05), 2,5-DCP, MEP primary contributions Mets. Conclusion Combined groups was related higher risk PAH group exhibiting most pronounced emerging key consistent robust findings, promoting public health concerns regarding hazards EDCs diseases.

Language: Английский

Citations

0