Journal of Obesity & Metabolic Syndrome, Journal Year: 2023, Volume and Issue: 32(1), P. 98 - 102
Published: Feb. 1, 2023
Background: Bariatric surgery is the most effective intervention for weight loss possibly through modulating subcutaneous adipose tissue (SAT) molecular programs.The post-operative and biological impacts, including gene expression, deserve in-depth investigation especially given small sample sizes in literature.Methods: Five existing datasets (n=237 SATs) were re-processed corrected batch-to-batch variation.Unsupervised approaches robust linear mixed effect model used to compare expression post-(n=126) pre-operation (n=111).Results: Post-operative SATs showed distinct global expression.Forty-four 395 genes over-and under-expressed post-operation (all Bonferroni P<0.05).The significantly enriched 21 processes/pathways P<0.05), 17 (76.2%)and two (9.5%) directly involved immunity amino/proteo-glycan metabolism, respectively.Conclusion: might adopt transcriptomic landscapes undergo a reduction immune-related processes metabolism.
Language: Английский