Archives of Physiology and Biochemistry,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 13
Published: Nov. 11, 2024
The
introduction
of
Tyrosine
Kinase
Inhibitors
(TKIs)
has
revolutionised
cancer
treatment,
yet
concerns
regarding
cardiovascular
toxicity
have
surfaced.
This
piece
delves
into
the
interplay
between
AMP-activated
protein
kinase
(AMPK)
signalling
and
TKI-induced
toxicity.
study
unravels
intricate
relationship
AMPK
activation
toxicity,
aiming
to
ascertain
whether
can
play
a
strategic
role
in
mitigating
adverse
effects.
Beyond
unravelling
mechanistic
insights,
research
sets
stage
for
future
therapeutic
approaches,
envisioning
as
pivotal
connection
balancing
effective
treatment
with
well-being.
As
advances,
potential
not
only
addresses
challenges
but
also
shapes
landscape
personalised
anticancer
therapies.
article
explores
mechanisms
AMPK's
impact
on
health,
implications
alleviating
TKI-associated
toxicities.
Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Aug. 20, 2024
AbstractBackground:
Organic
polymers
are
used
widely
in
daily
necessities,
foods,
and
medicines,
but
recent
reports
show
that
cross-linked
polyacrylic
acid
(CL-PAA),
an
organic
polymer,
induces
severe
lung
disease.
Whereas
most
previous
toxicity
studies
of
CL-PAA
were
intratracheal
instillation
studies,
we
conducted
inhalation
exposure
to
corroborate
those
findings.Methods:
We
5-day
(subacute)
13-week
(subchronic)
using
CL-PAA.
In
the
subacute
study,
male
F344
rats
inhaled
0.2
mg/m3,
2.0
or
20
mg/m3of
for
6
hours/day
5
days.
Rats
sacrificed
3
days
1
month
after
exposure.
subchronic
mg/m3or
mg/
m3of
days/week
13
weeks.
from
months
also
investigated
mechanism
pulmonary
disorders
by
conducting
additional
(CL-PAA
mg/m3)
which
antioxidant
N-acetylcysteine
(NAC)
(200
mg/kg)
was
injected
intraperitoneally.
The
study
on
day
exposure.Results:
Subacute
resulted
concentration-dependent
increases
neutrophil
influx,
total
protein,
lactate
dehydrogenase
(LDH),
cytokine-induced
chemoattractant
(CINC)
bronchoalveolar
lavage
fluid
(BALF),
heme
oxygenase-1
(HO-1)
tissue.
Histopathological
findings
tissue
showed
infiltration
a
manner.
Subchronic
persistent
protein
BALF
HO-1
fibrosis.
NAC
administration
decreased
number
neutrophils,
LDH,
CINC
BALF,
improved
infiltration.Conclusion:
Inhalation
induced
inflammation
rats'
lungs.
weeks
fibrosis
considered
no
observed
adverse
effect
level
(NOAEL)
chronic
mg/m3.
Furthermore,
oxidative
stress
associated
with
CL-PAA-induced
inflammation,
attenuated
inflammation.
BMC Genomics,
Journal Year:
2024,
Volume and Issue:
25(1)
Published: Nov. 6, 2024
Odontotermes
formosanus
(Shiraki)
is
a
highly
damaging
agroforestry
pest.
Serratia
marcescens
broad-spectrum
insecticidal
pathogen
and
lethal
to
O.
formosanus.
However,
little
known
about
the
mechanism
between
them.
To
improve
biological
control
of
pests,
more
in-depth
analysis
interactions
pests
pathogens
essential.
We
used
RNA-seq,
enzyme
activity
assays
real-time
fluorescent
quantitative
PCR
(qPCR)
explore
defense
responses
against
SM1.
RNA-seq
results
showed
that
1,160,
2,531
4,536
genes
were
differentially
expressed
at
3,
6
12
h
after
SM1
infection,
Kyoto
Encyclopedia
Genes
Genomes
(KEGG)
indicated
immune
response
energy
metabolism
involved
in
Reactive
oxygen
species
(ROS)
levels
ROS
synthesis
significantly
elevated,
antioxidant
system
induced
infection.
In
addition,
cellular
affected,
Toll,
deficiency
(Imd),
Janus
kinase/signal
transducer
activator
transcription
(JAK/STAT),
c-Jun
N-terminal
Kinase
(JNK)
melanization
pathways
activated.
vitro,
Oftermicin,
an
antimicrobial
peptide,
had
inhibitory
effect
on
Furthermore,
expression
activities
phosphofructokinase
(PFK),
lactate
dehydrogenase
(LDH),
succinate
(SDH)
isocitrate
(IDH)
glycolysis
tricarboxylic
acid
(TCA)
cycles
increased.
Our
clearly
demonstrated
defended
by
activating
system,
innate
immunity
metabolism.
This
study
would
provide
useful
information
for
development
controls
Archives of Physiology and Biochemistry,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 13
Published: Nov. 11, 2024
The
introduction
of
Tyrosine
Kinase
Inhibitors
(TKIs)
has
revolutionised
cancer
treatment,
yet
concerns
regarding
cardiovascular
toxicity
have
surfaced.
This
piece
delves
into
the
interplay
between
AMP-activated
protein
kinase
(AMPK)
signalling
and
TKI-induced
toxicity.
study
unravels
intricate
relationship
AMPK
activation
toxicity,
aiming
to
ascertain
whether
can
play
a
strategic
role
in
mitigating
adverse
effects.
Beyond
unravelling
mechanistic
insights,
research
sets
stage
for
future
therapeutic
approaches,
envisioning
as
pivotal
connection
balancing
effective
treatment
with
well-being.
As
advances,
potential
not
only
addresses
challenges
but
also
shapes
landscape
personalised
anticancer
therapies.
article
explores
mechanisms
AMPK's
impact
on
health,
implications
alleviating
TKI-associated
toxicities.
