Effects of Endocrine-Disrupting Heavy Metals on Human Health

Toxics, Journal Year: 2023, Volume and Issue: 11(4), P. 322 - 322

Published: March 29, 2023

Heavy metals play an important endocrine-disrupting role in the health consequences. However, mechanism of heavy is unclear. There are long-term and low-level metal/element exposure scenes for human body real life. Therefore, animal models exposed to high doses may not provide key information elucidate underlying pathogeny diseases. This review collects current knowledge regarding roles such as lead (Pb), cadmium (Cd), arsenic (As), mercury (Hg), nickel (Ni), copper (Cu), zinc (Zn), manganese (Mn), summarizes possible molecular mechanisms these chemicals (EDCs), briefly evaluates their endocrine toxicity on animals humans.

Language: Английский

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Pharmaceuticals as Emerging Pollutants: Implications for Water Resource Management in Malaysia

Emerging contaminants, Journal Year: 2025, Volume and Issue: unknown, P. 100470 - 100470

Published: Jan. 1, 2025

Language: Английский

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Environmental Aspect Concerning Phthalates Contamination: Analytical Approaches and Assessment of Biomonitoring in the Aquatic Environment

Environments, Journal Year: 2023, Volume and Issue: 10(6), P. 99 - 99

Published: June 10, 2023

This review is a survey of recent progress in studies concerning the impact phthalic acid esters aquatic organisms. After introducing classification, properties, sources, fate, and toxic effects related to phthalates, an overview techniques extraction analysis these substances provided. As result, general concepts environmental bioindicators, biomonitoring systems, other phthalate contamination environment are presented. Recent bioaccumulation data different phthalates summarised table organised according type organism, tissue, geographical area sampling. Bioindicator organisms that more representative highlighted discussed as along with variables may be relevant assessment pollution substances. The final part looks at perspectives suggests new directions research objectives achieved future.

Language: Английский

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RETRACTED ARTICLE: Exposure to pesticide components causes recurrent pregnancy loss by increasing placental oxidative stress and apoptosis: a case–control study

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: June 5, 2023

We investigated the plasma levels of pesticides components namely polychlorinated biphenyls (PCBs), dieldrin, dichlorodiphenyldichloroethylene (DDE), ethion, malathion, and chlorpyrifos in recurrent pregnancy loss (RPL) cases, tested their associations with placental oxidative stress (OS) biomarkers [nitric oxide (NO.), thiobarbituric acid reactive substances (TBARS), reduced glutathione (GSH), superoxide dismutase (SOD)] apoptotic/antiapoptotic indices (Bcl-2 caspase-3), evaluated possible cut-off points to distinguish RPL cases. The study recruited 101 pregnant women divided into; G1 [n = 49, control, normal 1st-trimester pregnancy, obstetric history at least one previous live birth], G2 26, cases missed abortion (< 3 abortions) before 24 weeks gestation], G3 (≥ gestation]. pesticide were analyzed by gas chromatography-mass spectrometry. Plasma human chorionic gonadotrophin (HCG), OS, Bcl-2, caspase-3, corresponding methods kits. PCBs, DDE, ethion significantly higher than pregnancies (p ≤ 0.001). These correlated positively OS apoptosis negatively HCG levels. Also, these reliable markers risk RPL. Malathion not detected any study's participants. Pesticides may be factors spontaneous They are associated an increasing apoptosis. Specific measures should taken decrease maternal exposure pollutants' sources, especially underdeveloped developing countries.

Language: Английский

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Heavy Metal Contamination: Sources, Health Impacts, and Sustainable Mitigation Strategies with Insights from Nigerian Case Studies

F1000Research, Journal Year: 2025, Volume and Issue: 14, P. 134 - 134

Published: Jan. 27, 2025

Heavy metal contamination has gradually become a very much important significant global issue due to its continual existence in the environment and bioaccumulation ecosystems, posing deleterious risks human health. This review aims investigate sources, pathways, toxicological impacts of heavy metals such as cadmium, lead, mercury, arsenic, elucidating their health consequences plausible mitigation strategies. Furthermore, explores dual origins contamination; natural geological processes anthropogenic activities industrial emissions, mining, agricultural practices. These sip into soil, water, food chains, leading bioaccumulation, bio-magnification causing risks, including cardiovascular diseases, neurological disorders, reproductive toxicity. Additionally, addition indigenous case studies from Nigeria, lead poisoning Zamfara State Great Kwa River Cross Rivers underscores disproportionate impact pollution developing nations. reveal socio-economic environmental dimensions issue, providing contextual understanding region-specific vulnerabilities outcomes. To address these problems, evaluates already existing strategies, chelation therapy phytoremediation, while proposing sustainable, cost-effective solutions for reducing exposure mitigating impacts. It emphasizes importance integrative approaches involving policy, community engagement, technological innovations fight effectively. In conclusion, this seminar contributes toxicity, giving showcasing insights sources implications contamination. By integrating theoretical perspectives with practical solutions, provides robust framework informing policy makers advancing sustainable management practices.

Language: Английский

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Heavy Metal Contamination: Sources, Health Impacts, and Sustainable Mitigation Strategies with Insights from Nigerian Case Studies

F1000Research, Journal Year: 2025, Volume and Issue: 14, P. 134 - 134

Published: Feb. 18, 2025

Heavy metal contamination has gradually become a very much important significant global issue due to its continual existence in the environment and bioaccumulation ecosystems, posing deleterious risks human health. This review aims investigate sources, pathways, toxicological impacts of heavy metals such as cadmium, lead, mercury, arsenic, elucidating their health consequences plausible mitigation strategies. Furthermore, explores dual origins contamination; natural geological processes anthropogenic activities industrial emissions, mining, agricultural practices. These sip into soil, water, food chains, leading bioaccumulation, bio-magnification causing risks, including cardiovascular diseases, neurological disorders, reproductive toxicity. Additionally, addition indigenous case studies from Nigeria, lead poisoning Zamfara State Great Kwa River Cross Rivers underscores disproportionate impact pollution developing nations. reveal socio-economic environmental dimensions issue, providing contextual understanding region-specific vulnerabilities outcomes. To address these problems, evaluates already existing strategies, chelation therapy phytoremediation, while proposing sustainable, cost-effective solutions for reducing exposure mitigating impacts. It emphasizes importance integrative approaches involving policy, community engagement, technological innovations fight effectively. In conclusion, this seminar contributes toxicity, giving showcasing insights sources implications contamination. By integrating theoretical perspectives with practical solutions, provides robust framework informing policy makers advancing sustainable management practices.

Language: Английский

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Early-life exposure to mixtures of Endocrine-Disrupting Chemicals and a Multi-domain Health Score in preschool children

Environmental Research, Journal Year: 2025, Volume and Issue: 272, P. 121173 - 121173

Published: Feb. 22, 2025

Language: Английский

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Insights into the Global and Mexican Context of Placental-Derived Pregnancy Complications

Biomedicines, Journal Year: 2025, Volume and Issue: 13(3), P. 595 - 595

Published: March 1, 2025

Placental-derived pregnancy complications encompass a range of disorders that hinder optimal fetal development, significantly impacting maternal and neonatal health outcomes. Key conditions include placental insufficiency, preeclampsia, growth restriction (FGR) or intrauterine (IUGR), overgrowth, gestational diabetes mellitus (GDM), which together contribute to heightened risk preterm birth, perinatal mortality, long-term developmental challenges in affected infants. These are particularly notable because they generate approximately 80% pose significant public concerns across diverse global contexts. Their management continues face challenges, including lack consensus on diagnostic criteria varied implementation care standards. While imaging techniques like magnetic resonance (MRI) Doppler ultrasound have emerged as critical tools clinical assessment, disparities access such technologies exacerbate existing inequalities Maternal is broad services aimed at promoting the well-being women throughout period. However, these often limited by economic, geographical, sociocultural barriers, for marginalized groups low- middle-income countries (LMICs). The targeted interventions designed address specific obstacles faced disadvantaged populations crucial component bridging gap equity care. Public authorities policymakers strive develop evidence-based strategies interplay between healthcare access, socioeconomic factors, effective order mitigate adverse effects placental-derived complications. Continued research data collection essential inform future policies practices improve outcomes mothers

Language: Английский

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Prenatal exposure to polychlorinated biphenyls is associated with markers of inflammation and oxidative stress in cord blood samples

Environmental Sciences Europe, Journal Year: 2025, Volume and Issue: 37(1)

Published: March 12, 2025

Language: Английский

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Development and validation of a survey on reproductive health behaviors to reduce exposure to endocrine-disrupting chemicals in Koreans

Frontiers in Reproductive Health, Journal Year: 2025, Volume and Issue: 7

Published: March 14, 2025

Recently, issues related to climate change and endocrine-disrupting chemicals have come the forefront. In particular, pursuit of convenience has led increased exposure in daily life, posing threats reproductive health, including infertility cancer. Therefore, this study aims develop a questionnaire assess health behaviors Koreans for reducing chemicals, verify its reliability validity. This methodological involved 288 adult men women South Korea conducted item analysis, exploratory factor confirmatory analysis. The developed survey consists four factors 19 detailed items promotion through main routes chemicals: food, respiratory pathways, skin absorption. Based on results study, it is hoped that research aimed at EDC will expand, considering various environments such as national ethnic differences.

Language: Английский

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