Construction of Bone Hypoxic Microenvironment Based on Bone-on-a-Chip Platforms DOI Open Access
Chen Li, Rong Zhao, Hui Yang

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(8), P. 6999 - 6999

Published: April 10, 2023

The normal physiological activities and functions of bone cells cannot be separated from the balance oxygenation level, are different under levels. At present, in vitro cell cultures generally performed a normoxic environment, partial pressure oxygen conventional incubator is set at 141 mmHg (18.6%, close to 20.1% ambient air). This value higher than mean human tissue. Additionally, further away endosteal sinusoids, lower content. It follows that construction hypoxic microenvironment key point experimental investigation. However, current methods cellular research realize precise control levels microscale, development microfluidic platforms can overcome inherent limitations these methods. In addition discussing characteristics tissue, this review will discuss various constructing gradients measuring tension microscale based on technology. integration advantages disadvantages perfect study help us responses more physiological-relevant conditions provide new strategy for future biomedicines.

Language: Английский

Oxidative stress as a key modulator of cell fate decision in osteoarthritis and osteoporosis: a narrative review DOI Creative Commons
Jana Riegger, Astrid Schoppa,

Leonie Ruths

et al.

Cellular & Molecular Biology Letters, Journal Year: 2023, Volume and Issue: 28(1)

Published: Sept. 30, 2023

Abstract During aging and after traumatic injuries, cartilage bone cells are exposed to various pathophysiologic mediators, including reactive oxygen species (ROS), damage-associated molecular patterns, proinflammatory cytokines. This detrimental environment triggers cellular stress subsequent dysfunction, which not only contributes the development of associated diseases, that is, osteoporosis osteoarthritis, but also impairs regenerative processes. To counter ROS-mediated reduce overall tissue damage, possess diverse defense mechanisms. However, antioxidative capacities limited thus ROS accumulation can lead aberrant cell fate decisions, have adverse effects on homeostasis. In this narrative review, we address oxidative as a major driver processes in bone, senescence, misdirected differentiation, death, mitochondrial impaired mitophagy by illustrating consequences homeostasis regeneration. Moreover, elaborate mechanisms, with particular focus response mitophagy, briefly discuss respective therapeutic strategies improve protection.

Language: Английский

Citations

81
Calcium supplementation attenuates fluoride-induced bone injury via PINK1/Parkin-mediated mitophagy and mitochondrial apoptosis in mice DOI
Yingjun Hu, Yuanyuan Li, Meng Li

et al.

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 465, P. 133411 - 133411

Published: Jan. 2, 2024

Language: Английский

Citations

21
Mitochondrial dysfunction and therapeutic perspectives in osteoporosis DOI Creative Commons
Jialing Liu,

Zhonghua Gao,

Xiangjie Liu

et al.

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 2, 2024

Osteoporosis (OP) is a systemic skeletal disorder characterized by reduced bone mass and structural deterioration of tissue, resulting in heightened vulnerability to fractures due increased fragility. This condition primarily arises from an imbalance between the processes resorption formation. Mitochondrial dysfunction has been reported potentially constitute one most crucial mechanisms influencing pathogenesis osteoporosis. In essence, mitochondria play role maintaining delicate equilibrium formation resorption, thereby ensuring optimal health. Nevertheless, disruption this balance can arise as consequence mitochondrial dysfunction. dysfunctional mitochondria, electron transport chain (ETC) becomes uncoupled, ATP synthesis generation reactive oxygen species (ROS). Reinforcement further exacerbated accumulation aberrant mitochondria. review, we investigated analyzed correlation dysfunction, encompassing DNA (mtDNA) alterations, oxidative phosphorylation (OXPHOS) impairment, mitophagy dysregulation, defects biogenesis dynamics, well excessive ROS accumulation, with regards OP ( Figure 1 ). Furthermore, explore prospective strategies currently available for modulating ameliorate Undoubtedly, certain therapeutic still require investigation ensure their safety efficacy clinical treatments. However, perspective, potential establishing effective safe approaches osteoporosis appears promising.

Language: Английский

Citations

20
Intervening with nanozymes in aging-related diseases: Strategies for restoring mitochondrial function DOI
Fanyong Yan, Dongyang Liu,

Baoshan Zhao

et al.

Biomaterials Advances, Journal Year: 2025, Volume and Issue: 169, P. 214193 - 214193

Published: Jan. 18, 2025

Language: Английский

Citations

2
Curcumin-loaded scaffolds in bone regeneration DOI Creative Commons

Mohammad Ebrahim Astaneh,

Fariba Noori, Narges Fereydouni

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(11), P. e32566 - e32566

Published: June 1, 2024

In recent years, there has been a notable surge in the development of engineered bone scaffolds intended for repair defects. While autografts and allografts have traditionally served as primary methods tissue engineering, their inherent limitations spurred exploration novel avenues biomedical implant development. The emergence not only facilitates reconstruction but also offers platform targeted delivery therapeutic agents. There exists pervasive interest leveraging various drugs, proteins, growth factors, biomolecules with osteogenic properties to augment formation, enduring side effects associated current clinical modalities necessitate pursuit safer alternatives. Curcumin, principal bioactive compound found turmeric, demonstrated efficacy regulating proliferation differentiation cells while promoting formation. Nevertheless, its utility is hindered by restricted water solubility poor bioavailability. Strategies aimed at enhancing solubility, stability, bioavailability curcumin, including formulation techniques such liposomes nanoparticles or complexation metals, explored. This investigation dedicated exploring impact curcumin on proliferation, differentiation, migration osteocytes, osteoblasts, osteoclasts.

Language: Английский

Citations

9
Mitochondrial dysfunction and mitophagy blockade contribute to renal osteodystrophy in chronic kidney disease-mineral bone disorder DOI
Shun‐Neng Hsu, Louise A. Stephen, Kanchan Phadwal

et al.

Kidney International, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

2
Identification of mitophagy-related biomarkers in human osteoporosis based on a machine learning model DOI Creative Commons
Yu Su,

Gangying Yu,

Dongchen Li

et al.

Frontiers in Physiology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 8, 2024

Osteoporosis (OP) is a chronic bone metabolic disease and serious global public health problem. Several studies have shown that mitophagy plays an important role in metabolism disorders; however, its osteoporosis remains unclear.

Language: Английский

Citations

7
Understanding the Consequences of Fatty Bone and Fatty Muscle: How the Osteosarcopenic Adiposity Phenotype Uncovers the Deterioration of Body Composition DOI Creative Commons
Kelsey Hu, Elizabeth Deya Edelen, Wenqing Zhuo

et al.

Metabolites, Journal Year: 2023, Volume and Issue: 13(10), P. 1056 - 1056

Published: Oct. 7, 2023

Adiposity is central to aging and several chronic diseases. encompasses not just the excess adipose tissue but also body fat redistribution, infiltration, hypertrophy of adipocytes, shifting mesenchymal stem cell commitment adipogenesis. Bone marrow expansion, inflammatory adipokines, adipocyte-derived extracellular vesicles are development osteopenic adiposity. Adipose infiltration local adipogenesis within muscle critical in developing sarcopenic adiposity subsequent poorer functional outcomes. Ultimately, osteosarcopenic syndrome result all processes noted above: adipocyte expansion redistribution bone, muscle, tissues, resulting bone loss, mass/strength deteriorated tissue, decline. Increased typically referred as obesity expressed by mass index (the latter often used inadequately), now occurring younger age groups, suggesting people will live longer with negative effects This review discusses role deterioration well itself. It reveals how considering including definition diagnosis adiposity, help better understanding pathophysiology each accelerate possible therapies prevention approaches for both relatively healthy individuals or those disease.

Language: Английский

Citations

16
Application of ChatGPT-4 to oculomics: a cost-effective osteoporosis risk assessment to enhance management as a proof-of-principles model in 3PM DOI
Joon Yul Choi,

Eoksoo Han,

Tae Keun Yoo

et al.

The EPMA Journal, Journal Year: 2024, Volume and Issue: 15(4), P. 659 - 676

Published: Aug. 28, 2024

Language: Английский

Citations

6
Irisin Protects Musculoskeletal Homeostasis via a Mitochondrial Quality Control Mechanism DOI Open Access
Chong Zhao, Yonghao Wu,

Shuaiqi Zhu

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(18), P. 10116 - 10116

Published: Sept. 20, 2024

Irisin, a myokine derived from fibronectin type III domain-containing 5 (FNDC5), is increasingly recognized for its protective role in musculoskeletal health through the modulation of mitochondrial quality control. This review synthesizes current understanding irisin’s impact on biogenesis, dynamics, and autophagy skeletal muscle, elucidating capacity to bolster muscle strength, endurance, resilience against oxidative-stress-induced atrophy. The multifunctional nature irisin extends bone metabolism, where it promotes osteoblast proliferation differentiation, offering potential intervention osteoporosis other disorders. Mitochondrial control vital cellular particularly energy-demanding tissues. Irisin’s influence this process highlighted, suggesting integral maintaining homeostasis. also touches upon regulatory mechanisms secretion, predominantly induced by exercise, systemic effects as an endocrine factor. While therapeutic promising, need standardized measurement techniques further elucidation humans acknowledged. collective findings underscore burgeoning interest keystone candidate future strategies.

Language: Английский

Citations

4