Association between obstructive sleep apnea and visceral adiposity index and lipid accumulation product: NHANES 2015–2018

Lipids in Health and Disease, Journal Year: 2024, Volume and Issue: 23(1)

Published: April 10, 2024

Obesity refers to a significant contributor the development of obstructive sleep apnea (OSA). Early prediction OSA usually leads better treatment outcomes, and this study aims employ novel metabolic markers, visceral adiposity index (VAI), lipid accumulation product (LAP) evaluate relationship OSA.

Language: Английский

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Prognostic effect of triglyceride glucose-related parameters on all-cause and cardiovascular mortality in the United States adults with metabolic dysfunction-associated steatotic liver disease

Cardiovascular Diabetology, Journal Year: 2024, Volume and Issue: 23(1)

Published: June 1, 2024

Abstract Backgrounds Insulin resistance (IR) plays a vital role in the pathogenesis of metabolic dysfunction-associated steatotic liver disease (MASLD). However, it remains unclear whether triglyceride–glucose (TyG) related parameters, which serve as useful biomarkers to assess IR, have prognostic effects on mortality outcomes MASLD. Methods Participants National Health and Nutrition Examination Survey (NHANES) database from 1999 2018 years were included. TyG its parameters [TyG-waist circumference (TyG-WC) TyG-waist height ratio (TyG-WHtR)] calculated. Kaplan–Meier curves, Cox regression analysis, restricted cubic splines (RCS) conducted evaluate association between TyG-related indices with all-cause cardiovascular adults The concordance index (C-index) was used prediction accuracy indices. Results A total 8208 (4209 men 3999 women, median age 49.00 years) MASLD included this study. Multivariate-adjusted analysis revealed that high quartile levels significantly associated participants [ adjusted hazard (aHR) = 1.25, 95% confidence interval (CI) 1.05–1.50, P 0.014; TyG-WC aHR for 1.28, CI 1.07–1.52, 0.006; TyG-WHtR 1.50, 1.25–1.80, < 0.001; 1.81, 1.28–2.55, 2.22, 1.55–3.17, 0.001]. C-index predicting 0.563 index, 0.579 0.585 respectively. Regarding mortality, 0.561 0.607 0.615 Nonlinear trends observed ( 0.001 0.012, respectively). non-linear relationship 0.025). Subgroup suggested aged 65 old those without comorbidities more sensitive Conclusion Findings study highlight predictive value indices, especially would be surrogate clinical management

Language: Английский

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Development and validation of machine learning models for MASLD: based on multiple potential screening indicators

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 21, 2025

Background Multifaceted factors play a crucial role in the prevention and treatment of metabolic dysfunction-associated steatotic liver disease (MASLD). This study aimed to utilize multifaceted indicators construct MASLD risk prediction machine learning models explore core within these models. Methods were constructed based on seven algorithms using all variables, insulin-related demographic characteristics other indicators, respectively. Subsequently, partial dependence plot(PDP) method SHapley Additive exPlanations (SHAP) utilized explain roles important variables model filter out optimal for constructing model. Results Ranking feature importance Random Forest (RF) eXtreme Gradient Boosting (XGBoost) found that both homeostasis assessment insulin resistance (HOMA-IR) triglyceride glucose-waist circumference (TyG-WC) first second most variables. The with top 10 was superior previous PDP SHAP methods further screen best (including HOMA-IR, TyG-WC, age, aspartate aminotransferase (AST), ethnicity) model, mean area under curve value 0.960. Conclusions HOMA-IR TyG-WC are predicting risk. Ultimately, our AST, ethnicity.

Language: Английский

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Positive association between different triglyceride glucose index-related indicators and psoriasis: evidence from NHANES

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Dec. 20, 2023

Background Psoriasis is a chronic inflammatory skin disease with effects that extend beyond the skin. Insulin resistance (IR) has been associated psoriasis, but it remains unclear how indicators related to triglyceride glucose (TyG) index, which were associate IR, are condition. Objective The purpose of this study was investigate association between psoriasis and three TyG-related indicators: glucose-body mass index (TyG-BMI), glucose-waist height ratio (TyG-WHtR), circumference (TyG-WC). Methods Data from adults aged 20 80 years in National Health Nutrition Examination Survey (NHANES) 2003 2006 2009 2014 utilized. Institutional Review Board approval documented written consent obtained participants by NHANES (Protocol #2005–06). patients divided into groups based on TyG-BMI, TyG-WC, TyG-WHtR: Q1 (1st quintile), Q2 (2nd-3rd quintiles), Q3 (4th-5th quintiles). Differences further explored. Multivariate logistic regressions used correlation these results expressed as odds ratios (OR) 95% confidence intervals (CI). Subgroup analysis supplementary conducted explore potential influencing factors. Results included 9,291 participants, 260 had psoriasis. Compared TyG-WHtR Q1, there significantly Among indicators, TyG-WC consistently highest OR values Models 1 2 (Model 1: (95% CI) = 2.155 (1.442-3.220); Model 2: 2.029 (1.341-3.069)). While 3, TyG-BMI shows more significant relationship 3 TyG-BMI: 1.948 (1.300-3.000)). Similar observed majority subgroups analysis. Conclusion This identified stable strong positive (TyG-BMI, TyG-WHtR) persisted even after adjusting for multiple It suggested high IR

Language: Английский

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NAFLD in the 21st Century: Current Knowledge Regarding Its Pathogenesis, Diagnosis and Therapeutics

Biomedicines, Journal Year: 2024, Volume and Issue: 12(4), P. 826 - 826

Published: April 9, 2024

Non-alcoholic fatty liver disease (NAFLD) is a major public health issue worldwide. It the most common in Western countries, andits global prevalence estimated to be up 35%. However, its diagnosis may elusive, because biopsy relatively rarely performed and usually only advanced stages of disease. Therefore, several non-invasive scores applied more easily diagnose monitor NAFLD. In this review, we discuss various biomarkers imaging that could useful diagnosing managing Despite fact general measures, such as abstinence from alcohol modulation other cardiovascular risk factors, should applied, mainstay prevention management weight loss. Bariatric surgery suggested means confront addition, pharmacological treatment with GLP-1 analogues or GIP agonist tirzepatide advisable. focus on utility agonists lowering body weight, their pharmaceutical potential, safety profile, already evidenced inanimal human studies. We also elaborate options, use vitamin E, probiotics, especially next-generation prebiotics context. Finally, explore future perspectives regarding administration analogues, agonists, probiotics/prebiotics prevent combat The newest drugs pegozafermin resmetiron, which seem very promising, arealso discussed.

Language: Английский

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Association between different triglyceride glucose index-related indicators and depression in premenopausal and postmenopausal women: NHANES, 2013–2016

Journal of Affective Disorders, Journal Year: 2024, Volume and Issue: 360, P. 297 - 304

Published: May 31, 2024

Language: Английский

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Diagnostic performance of sixteen biomarkers for MASLD: A study in a Mexican cohort

Clinics and Research in Hepatology and Gastroenterology, Journal Year: 2024, Volume and Issue: 48(7), P. 102400 - 102400

Published: June 18, 2024

Language: Английский

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Association between the triglyceride-glucose index and liver fibrosis in adults with metabolism-related fatty liver disease in the United States: a cross-sectional study of NHANES 2017–2020

BMC Gastroenterology, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 2, 2025

This study aimed to examine the association between triglyceride-glucose (TyG) index and liver fibrosis (LF) in U.S. adults with Metabolic Dysfunction-Associated Steatotic Liver Disease (MAFLD). Using data from 2017 2020 National Health Nutrition Examination Survey (NHANES) database, we conducted a population-based cross-sectional 1,324 participants. MAFLD was defined as controlled attenuation parameter (CAP) score ≥ 248 dB/m accompanied by metabolic dysfunction. A median stiffness measurement 8.2 kPa used identify significant (≥ F2). Multivariable logistic regression employed assess impact of TyG on LF outcomes. restricted cubic spline (RCS) model explore nonlinear effects, receiver operating characteristic (ROC) curves were applied evaluate effectiveness predicting. Among participants, 716 men 608 women, aged 20 80 years, representing various racial groups. Significant observed 137 out After adjusting for confounding factors, higher significantly associated an increased incidence MAFLD-related (OR = 2.18, 95% CI, 1.14–4.18; p < 0.05). Elevated levels showed positive correlation fibrosis, odds ratio (OR) exceeding 1 when above 8.054. Subgroup analyses stratified sex, age, body mass (BMI) revealed differences after confounders. The stronger women 2.53, 1.16–5.53) than 1.95, 0.81–4.72). also found obesity status (overweight: OR 4.80, 1.27–18.2; obese: 2.26, 1.20–5.53). In patients 40–59, strongly 2.85, 1.16–6.79). Furthermore, area under ROC curve (AUC) predicting 0.73 (95% 0.68–0.78), indicating moderate predictive ability. general population, elevated positively risk patients.

Language: Английский

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Correlation analysis of the triglyceride–glucose index and related parameters in metabolic dysfunction-associated fatty liver disease

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 2, 2025

Language: Английский

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Markers of insulin resistance associated with non-alcoholic fatty liver disease in non-diabetic population

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: Nov. 22, 2023

Insulin resistance (IR) plays an important role in the development of non-alcoholic fatty liver disease (NAFLD). IR markers are divided into two types: (1) insulin-based marker, homeostatic model assessment (HOMA-IR); and (2) non-insulin-based markers, such as triglyceride-glucose (TyG) index, TyG index with body mass (TyG-BMI), triglyceride/high-density lipoprotein cholesterol ratio (TG/HDL-c), metabolic score for (METS-IR). The often associated lipids. aim this study was to analyse association between NAFLD non-diabetic population. Baseline data non-NAFLD groups were compared. Logistic regression used evaluate relationship five risk. odds ratios (ORs) 95% confidence intervals (CIs) calculated. Receiver operating characteristic (ROC) curves area under curve (AUC) ability different detect NAFLD. Subgroup analyses performed obese non-obese subgroups. This found a positive correlation risk elevation (HOMA-IR, TyG, TyG-BMI, TG/HDL-c, METS-IR). In subjects, AUC TyG-BMI larger than that other four HOMA-IR subjects. population, NAFLD, including can be respectively, better detection compared markers.

Language: Английский

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