Scientific Reports,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: May 3, 2025
Chronic
kidney
disease
(CKD)
is
highly
prevalent,
incurable,
and
lacks
effective
treatments.
Aging
closely
linked
to
various
diseases.
In
this
study,
we
combined
CKD
aging
using
bioinformatics
approaches
identify
potential
anti
drugs
therapeutic
targets
for
CKD.
We
analyzed
datasets
GSE37171
GSE66494
from
the
GEO
database,
identifying
317
differentially
expressed
genes
(DEGs).
By
intersecting
these
DEGs
with
related
genes,
identified
23
associated
differential
(ARDEGs).
A
protein-protein
interaction
(PPI)
network
was
constructed
STRING
top
10
hub
ARDEGs
were
Cytoscape
software.
Potential
drugs,
including
Cinnamaldehyde,
through
ceRNA
transcription
factor
regulatory
networks,
as
well
DGldb
database.
Among
key
in
patient
samples
SOD2,
FGF21,
FOS,
RELA,
DDIT4,
BMI1,
DUSP6,
LGALS3,
CXCR2,
CEBPB.
Cinnamaldehyde
other
found
target
pathways,
suggesting
their
delay
progression
modulating
pathways.
Finally,
verified
low-expression
of
DDIT4
two
unilateral
ureteral
obstruction
(UUO)
animal
model.
Additionally,
shown
reduce
expression
fibrosis
markers
such
fibronectin
(FN)
α-smooth
muscle
actin
(α-SMA)
HK2
cells
under
TGF-β1
stimulation.
This
study
provides
a
foundational
understanding
molecular
offers
new
directions
developing
therapies
treat
Cell Death and Disease,
Journal Year:
2024,
Volume and Issue:
15(5)
Published: May 14, 2024
Abstract
Fibrosis
is
a
reparative
and
progressive
process
characterized
by
abnormal
extracellular
matrix
deposition,
contributing
to
organ
dysfunction
in
chronic
diseases.
The
tumor
suppressor
p53
(p53),
known
for
its
regulatory
roles
cell
proliferation,
apoptosis,
aging,
metabolism
across
diverse
tissues,
appears
play
pivotal
role
aggravating
biological
processes
such
as
epithelial-mesenchymal
transition
(EMT),
senescence.
These
are
closely
intertwined
with
the
pathogenesis
of
fibrotic
disease.
In
this
review,
we
briefly
introduce
background
specific
mechanism
p53,
investigate
fibrosis,
further
discuss
p53’s
relationship
fibrosis
affecting
kidney,
liver,
lung,
heart.
summary,
targeting
represents
promising
innovative
therapeutic
approach
prevention
treatment
fibrosis.
Frontiers in Pharmacology,
Journal Year:
2025,
Volume and Issue:
16
Published: Jan. 22, 2025
Acute
kidney
injury
(AKI)
is
a
common
critical
clinical
disease
that
linked
to
significant
morbidity,
recurrence,
and
mortality.
It
characterized
by
fast
prolonged
loss
in
renal
function
arising
from
numerous
etiologies
pathogenic
pathways.
Renal
fibrosis,
defined
as
the
excessive
accumulation
of
collagen
proliferation
fibroblasts
within
tissues,
contributes
structural
damage
functional
decline
kidneys,
playing
pivotal
role
advancement
Chronic
Kidney
Disease
(CKD).
Until
now,
while
continuous
replacement
therapy
(CRRT)
has
been
utilized
management
severe
AKI,
there
remains
dearth
effective
targeted
therapies
for
AKI
stemming
diverse
etiologies.
Similarly,
identification
specific
biomarkers
pharmacological
targets
treatment
fibrosis
challenge.
Baicalin,
naturally
occurring
compound
classified
flavonoid
group
commonly
found
Chinese
herb
Scutellaria
baicalensis,
shown
range
characteristics,
such
antioxidant,
anti-inflammatory,
antifibrotic,
antitumor
antiviral
effects,
evidenced
research
studies.
Research
shows
Baicalin
potential
treating
diseases
like
fibrosis.
This
review
aims
summarize
Baicalin’s
progress
these
areas,
including
its
molecular
mechanism,
application
treatment,
absorption,
distribution,
metabolism,
excretion.
therapeutic
effects
are
achieved
through
various
pathways,
antifibrosis,
regulation
apoptosis
cell
proliferation.
Besides,
we
also
hope
this
may
give
some
enlightenment
practice.
Lipids,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 25, 2025
Abstract
Lipid‐lowering
drugs
have
been
used
in
clinics
widely.
It
is
unclear
whether
the
an
effect
on
renal
failure.
We
chose
high‐density
lipoprotein
cholesterol
(ieu‐b‐109),
low‐density
(ieu‐a‐300),
triglyceride
(ieu‐b‐111),
and
total
(ebi‐a‐GCST90038690)
as
exposures.
SNPs
near
drug
genes
served
instrumental
variables.
Acute
failure
(ARF)
chronic
(CRF)
Europeans
from
GWAS
catalog
were
selected
outcomes.
Datasets
East
Asians
South
for
validation.
Inverse
variance
weighted
(IVW)
was
primary
method
drug‐targeted
Mendelian
randomization.
In
Europeans,
people
who
PPARG
reduced
ARF
risk
by
69.3%
(OR:
0.307,
95%
CI:
0.171–0.553,
p
=
0.015).
NPC1L1
inhibitors
increased
2.684
times
2.684,
2.027–3.341,
0.003).
APOE
1.987
1.987,
1.062–3.716,
0.032)
but
decreased
CRF
49.7%
0.503,
0.283–0.894,
0.019).
TNFSF12
3.866
3.866,
1.174–12.729,
0.026).
Asians,
85.8%
0.142,
0.054–0.371,
<
0.001).
And
99.8%
0.002,
2.12e‐05‐0.179,
0.007).
revealed
that
could
reduce
of
Asians.
cause
it
protective
Clinicians
need
to
consider
characteristics
local
population
before
administering
patients
different
ethnicities.
The FASEB Journal,
Journal Year:
2025,
Volume and Issue:
39(5)
Published: March 1, 2025
Abstract
Aging
is
a
biological
process
along
with
systemic
and
multiple
organ
dysfunction.
It
more
recognized
that
aging
disease
instead
of
single‐organ
functional
disorder.
Systemic
plays
profound
role
in
diseases
including
neurodegenerative
diseases,
cardiovascular
malignant
diseases.
Aged
organs
communicate
other
accelerate
aging.
Skeletal
muscle,
heart,
bone
marrow,
skin,
liver
each
through
organ–organ
crosstalk.
The
crosstalk
can
be
mediated
by
metabolites
lipids,
glucose,
short‐chain
fatty
acids
(SCFA),
inflammatory
cytokines,
exosomes.
Metabolic
disorders
hyperglycemia,
hyperinsulinemia,
hypercholesterolemia
caused
chronic
hallmarks
leads
to
the
destruction
hemostasis,
causes
release
senescence‐associated
secretory
phenotype
(SASP),
imbalance
microbiota
composition.
Released
factors
further
aggregate
senescence,
which
promotes
solid
organs.
Targeting
senescence
or
delaying
emerging
as
critical
health
strategy
for
solving
age‐related
especially
old
population.
In
current
review,
we
will
delineate
mechanisms
provide
therapeutic
targets
