Fruit Intake and Alzheimer’s Disease: Results from Mendelian Randomization DOI Creative Commons
Wan‐Zhe Liao, Xiaofeng Zhu, Qing Xin

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: May 10, 2023

Abstract Background Alzheimer's disease (AD) is the leading cause of dementia in old age, recognized as a global health priority. The number patients projected to reach 152 million worldwide by mid-century. AD can damage thought, memory, and independence, increasing risk dependence, disability, mortality. aim present study explore precise causality from fruit intake on AD. Methods To causal effect fresh dried liability AD, this utilized genome-wide association (GWAS) developed MRC-IEU for full UK Biobank GWAS FinnGen round 8 conduct Mendelian randomization (MR) analysis. instrumental variables (IVs) each were selected based InSIDE hypothesis exposure-outcome datasets harmonized. used inverse variance weighted (IVW), MR‒Egger, median (WM) approaches MR estimates, scatter plots, funnel leave-one-out plots generated statistical inspection stability results. Results analyses conducted investigate effects using targeted datasets. Little evidence suggested potential relationship between (OR (95%CI) = 0.97 (0.50, 1.91), P-value 0.939), while significant intensive was indicated 4.09 (2.07, 8.10), < 0.001). Stability evaluations showed no heterogeneity pleiotropy affecting interpretability credibility primary analyses. Conclusions We strengthened supporting positive Alzheimer’s disease, failed be demonstrated. Further validation focusing underlying molecular mechanisms expansility ethnicity could strengthen reliability diet intervention throughout prevention

Language: Английский

The BrainLat project, a multimodal neuroimaging dataset of neurodegeneration from underrepresented backgrounds DOI Creative Commons
Pavel Prado, Vicente Medel, Raúl González-Gómez

et al.

Scientific Data, Journal Year: 2023, Volume and Issue: 10(1)

Published: Dec. 9, 2023

Abstract The Latin American Brain Health Institute (BrainLat) has released a unique multimodal neuroimaging dataset of 780 participants from American. includes 530 patients with neurodegenerative diseases such as Alzheimer’s disease (AD), behavioral variant frontotemporal dementia (bvFTD), multiple sclerosis (MS), Parkinson’s (PD), and 250 healthy controls (HCs). This (62.7 ± 9.5 years, age range 21–89 years) was collected through multicentric effort across five countries to address the need for affordable, scalable, available biomarkers in regions larger inequities. BrainLat is first regional collection clinical cognitive assessments, anatomical magnetic resonance imaging (MRI), resting-state functional MRI (fMRI), diffusion-weighted (DWI), high density electroencephalography (EEG) patients. In addition, it demographic information about harmonized recruitment assessment protocols. publicly encourage further research development tools health applications neurodegeneration based on neuroimaging, promoting variability inclusion underrepresented research.

Language: Английский

Citations

19
Causal Relationship Between Different Sleep Traits and Dental Caries: A Bidirectional Mendelian Randomization Study DOI
Dan Zhou, Zehan Zhang, Jianxing Zhang

et al.

International Journal of Behavioral Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 27, 2025

Language: Английский

Citations

0
The causal association between circulating metabolites and Alzheimer’s disease: a systematic review and meta-analysis of Mendelian randomization studies DOI Creative Commons

Yuxuan Wu,

Fangying Chen,

Tingting Zhang

et al.

Metabolomics, Journal Year: 2025, Volume and Issue: 21(3)

Published: April 21, 2025

Some Mendelian randomization (MR) studies have found that there may be a genetic causal relationship between circulating metabolites and Alzheimer 's disease (AD), but the strength of evidence direction association are not always consistent. In this study, systematic review meta-analysis all literature using MR methods to study AD was conducted enhance robustness correlation predicting causality. We comprehensive which within timeframe years 20 December 2023. Circulating were considered as exposure factor, served outcome. Two researchers, each with relevant professional backgrounds, independently evaluated quality extracted data from selected studies. Meta-analysis carried out R Studio version 4.3.1. total, 30 included, 13 for meta-analysis. The results revealed genetically predicted high levels some associated reduced risk AD. (HDL-C: OR = 0.90, 95% CI 0.83-0.97, p 0.004; Testosterone: 0.93, 0.90-0.97, 0.001; Male hormones exclude testosterone: 0.85, 0.75-0.96, 0.007; Glutamine: 0.81-0.89, < 0.001) Meanwhile, LDL-C an increased (LDL-C: 1.52, 1.15-2.00, 0.003). There is enough prove diabetes (OR 1.02, 1.00-1.03, 0.12).

Language: Английский

Citations

0
Progress on early diagnosing Alzheimer’s disease DOI
Yixin Chen, Murad Al‐Nusaif, Song Li

et al.

Frontiers of Medicine, Journal Year: 2024, Volume and Issue: 18(3), P. 446 - 464

Published: May 21, 2024

Language: Английский

Citations

3
Hydrocortisone Mitigates Alzheimer’s-Related Cognitive Decline through Modulating Oxidative Stress and Neuroinflammation DOI Creative Commons

Jinran Li,

Long Chen, Sai Liu

et al.

Cells, Journal Year: 2023, Volume and Issue: 12(19), P. 2348 - 2348

Published: Sept. 25, 2023

Alzheimer's disease (AD), an age-related degenerative disorder, is characterized by β-amyloid deposition, abnormal phosphorylation of tau proteins, synaptic dysfunction, neuroinflammation, and oxidative stress. Despite extensive research, there are no medications or therapeutic interventions to completely treat reverse AD. Herein, we explore the potential hydrocortisone (HC), a natural endogenous glucocorticoid known have potent anti-inflammatory properties, in Aβ1-42-induced AD mouse model. Our investigation highlights beneficial effects HC administration on cognitive impairment, function enhancement, neuronal protection mice. Notably, treatment effectively suppresses hyperactivation microglia astrocytes, leading reduction proinflammatory factors alleviation neuroinflammation. Furthermore, intervention demonstrates capacity mitigate generation ROS These compelling findings underscore application present promising opportunities for its utilization prevention treatment. The implications drawn from our indicate that holds promise as viable candidate adjunctive use with other anti-AD drugs clinical management patients presenting moderate severe

Language: Английский

Citations

8
Circadian rhythm of brain‐derived neurotrophic factor in serum and plasma DOI Creative Commons
M. Ehrhardt, Stefanie Schreiber, Yves Duderstadt

et al.

Experimental Physiology, Journal Year: 2024, Volume and Issue: 109(10), P. 1755 - 1767

Published: Aug. 6, 2024

The neurotrophic growth factor brain-derived (BDNF) plays a crucial role in various neurodegenerative and psychiatric diseases, such as Alzheimer's disease, schizophrenia depression. BDNF has been proposed potential biomarker for diagnosis, prognosis monitoring therapy. Understanding the factors influencing levels whether they follow circadian rhythm is essential interpreting fluctuations measurements. We aimed to investigate of by collecting multiple peripheral venous blood samples from young, healthy male participants at 12 different time points over 24 h. In addition, vital parameters, cortisol insulin like 1 (IGF1) were measured explore regulatory mechanisms, interfering variables their correlations with concentration. findings revealed that plasma did not exhibit any significant h, suggesting absence rhythm. However, serum decreased during sleep. Furthermore, showed positive correlation heart rate but negative IGF1. No was observed between or Although suggests steady-state conditions, decline nocturnal period could be attributed physical inactivity associated reduced haemodynamic flow (heart reduction sleep). type sample collection (peripheral cannula vs. sampling using butterfly system) does significantly affect levels. day analysis, emphasizing importance considering activity rather than timing when designing standardized protocols assessments.

Language: Английский

Citations

2
A two-sample Mendelian randomization study of atherosclerosis and dementia DOI Creative Commons
Qiaoyun Zhang, Guangheng Wu, Xiaoyu Zhang

et al.

iScience, Journal Year: 2023, Volume and Issue: 26(11), P. 108325 - 108325

Published: Oct. 24, 2023

The causality between atherosclerosis and dementia remains unclear. This study aimed to explore the causal effect of related indicators on risk based two-sample Mendelian randomization (MR) using summary statistics genome-wide association studies (GWASs). inverse variance weighted (IVW) method was performed as main analysis, supplemented by different sensitivity analyses. Suggestive evidence indicated that peripheral arterial disease (PAD) (odds ratio (OR): 0.864, 95% confidence interval (CI): 0.797-0.937), coronary (CoAS) (OR: 0.927, CI: 0.860-0.998) atherosclerosis, excluding cerebral, coronary, PAD (ATHSCLE) 0.812, 0.725-0.909) were inversely associated with AD. analysis confirmed a suggestive reverse ATHSCLE frontotemporal (FTD) (OR, CI, 0.725-0.909). Findings provide PAD, CoAS, might be AD or FTD, which requires further exploration in larger samples.

Language: Английский

Citations

2
Causal relationship between psoriasis vulgaris and dementia: Insights from Mendelian randomization analysis DOI
Zehan Zhang, Wenxiu Xu, Yuxiao Zheng

et al.

Experimental Dermatology, Journal Year: 2023, Volume and Issue: 33(1)

Published: Nov. 23, 2023

Abstract Many clinical studies have demonstrated a correlation between psoriasis vulgaris and dementia, yet this remains controversial. Our study employed the Mendelian randomization (MR) method to investigate causal relationship dementia. Data were obtained from summary statistics of genome‐wide association IEU‐OpenGWAS project database. In univariate (UVMR) analysis, was used as exposure. Alzheimer disease (AD), vascular dementia (VaD), with Lewy bodies (DLB), Parkinson's (PDD) frontotemporal (FTD) served outcomes. multivariate (MVMR) VaD outcome. The first MVMR analysis vulgaris, mean platelet volume (MPV), distribution width (PDW) count (PLT) exposures. second vitamin D level 25 hydroxyvitamin main inverse variance weighted method, outcomes evaluated by odds ratio (OR) 95% confidence interval (95% CI). UVMR results depicted that associated (OR: 0.903, CI: 0.818–0.996, p = 0.041). revealed insignificant associations other types. After adjusting effects MPV, PDW PLT in no longer significant ( 0.164). Similarly, after also 0.533). suggests may potentially decrease incidence. However, be impeded platelet‐related indices, level.

Language: Английский

Citations

2
Two-sample Mendelian randomization study: iron deficiency anemia increases the risk of epilepsy DOI

Yu Tong,

Xianyun Liu, Wenqi Yang

et al.

Nutrition & Food Science, Journal Year: 2024, Volume and Issue: 54(8), P. 1478 - 1486

Published: Aug. 20, 2024

Purpose Iron deficiency anemia (IDA) is the most common form of in world, affecting children, women and elderly, while also being a comorbidity several medical conditions. Several studies have suggested possible association between IDA neurological dysfunction. Epilepsy, one disorders, has an unknown with IDA. This pa per aims to investigate whether there causal relationship epilepsy using two-sample Mendelian randomization (MR) design. Design/methodology/approach paper obtained summary data on from FinnGen consortium. Genetic variants significantly associated were used as instrumental variables (IVs). focal generalized outcomes. inverse variance weighted (IVW) primary estimate, other MR methods supplementary measures. Sensitivity analysis was performed assess heterogeneity pleiotropy. Findings IVW estimates genetically predicted risk [odds ratio (OR), 1.15; 95% confidence interval (95% CI), 1.05–1.26; p = 0.002] (OR, 1.978, CI, 1.58–2.48, ≤ 0.0001), no significant found 1.1, 0.94–1.3, 0.24). There evidence horizontal pleiotropy sensitivity analysis. Originality/value study that negative effect development epilepsy. Clinical control may be helpful prevention need for further explain underlying mechanisms this association.

Language: Английский

Citations

0
Neurodegeneration and Cognitive Dysfunction in Multiple Sclerosis DOI Open Access
Ya.V. Spivak

Reports of Vinnytsia National Medical University, Journal Year: 2024, Volume and Issue: 28(3), P. 550 - 561

Published: Sept. 25, 2024

Annotation. In most cases, treatment does not take into account the state of cognition, which always accompanies patient in form cognitive disorders varying degrees severity. To date, there is no established system for comprehensive examination patients with multiple sclerosis that includes only management classic syndromes but also diagnosis and disorders. The objective to review scientific sources on sclerosis, analyze latest data characteristics dysfunction neurodegeneration sclerosis. From databases PubMed, ScienceDirect, UpToDate, Web Science, Scopus, 50 were selected reviewed met query conditions: recent publications (within last 5 years) or this issue regardless age. It currently known disorders, as a result neurodegeneration, significantly affect quality life This generates significant interest, their presence can delay diagnosis, alter progression neurological deficits, reduce physical activity, exacerbate severity primary disease symptoms. Cognitive function understood complex mechanisms by process rational cognition surrounding environment interaction it carried out. assess both series tests evaluation gray matter atrophy MRI studies be helpful. Thus, literature analysis showed impact course relevant requires further study.

Language: Английский

Citations

0