Fruit Intake and Alzheimer’s Disease: Results from Mendelian Randomization DOI Creative Commons
Wan‐Zhe Liao, Xiaofeng Zhu, Qing Xin

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: May 10, 2023

Abstract Background Alzheimer's disease (AD) is the leading cause of dementia in old age, recognized as a global health priority. The number patients projected to reach 152 million worldwide by mid-century. AD can damage thought, memory, and independence, increasing risk dependence, disability, mortality. aim present study explore precise causality from fruit intake on AD. Methods To causal effect fresh dried liability AD, this utilized genome-wide association (GWAS) developed MRC-IEU for full UK Biobank GWAS FinnGen round 8 conduct Mendelian randomization (MR) analysis. instrumental variables (IVs) each were selected based InSIDE hypothesis exposure-outcome datasets harmonized. used inverse variance weighted (IVW), MR‒Egger, median (WM) approaches MR estimates, scatter plots, funnel leave-one-out plots generated statistical inspection stability results. Results analyses conducted investigate effects using targeted datasets. Little evidence suggested potential relationship between (OR (95%CI) = 0.97 (0.50, 1.91), P-value 0.939), while significant intensive was indicated 4.09 (2.07, 8.10), < 0.001). Stability evaluations showed no heterogeneity pleiotropy affecting interpretability credibility primary analyses. Conclusions We strengthened supporting positive Alzheimer’s disease, failed be demonstrated. Further validation focusing underlying molecular mechanisms expansility ethnicity could strengthen reliability diet intervention throughout prevention

Language: Английский

The Role of Adrenaline, Noradrenaline, and Cortisol in the Pathogenesis of the Analgesic Potency, Duration, and Neurotoxic Effect of Meperidine DOI Creative Commons
Mehmet Yılmaz, Bahadır Süleyman, Renad Mammadov

et al.

Medicina, Journal Year: 2023, Volume and Issue: 59(10), P. 1793 - 1793

Published: Oct. 9, 2023

Background and Objectives: The purpose of the study was to investigate role adrenaline (ADR), noradrenaline (NDR), cortisol in pathogenesis analgesic potency, duration, epilepsy-like toxic effect meperidine. Materials Methods: experimental animals were separated into 11 groups six rats. In meperidine (MPD) metyrosine + (MMPD) groups, paw pain thresholds measured before after treatment between first sixth hours (one hour apart). addition, ADR NDR analyses performed treatment, fourth For epilepsy experiment, caffeine, caffeine meperidine, metyrapone created, applied for 1 day or 7 days. Groups created which used at both 150 mg/kg 300 mg/kg. Epileptic seizures observed latent periods determined, serum levels measured. Results: MPD group, increased only second compared pre-treatment, while third hour, leading a decrease thresholds. MMPD increase 6 h accompanied by NDR. (150 mg/kg) 1-day did not cause epileptic seizures, group continued When (300 days receiving days, it found that decreased period decreased. Conclusions: current showed if are kept normal levels, longer-lasting stronger can be achieved with prevented.

Language: Английский

Citations

1
Fruit Intake and Alzheimer’s Disease: Results from Mendelian Randomization DOI Creative Commons
Wan‐Zhe Liao, Xiaofeng Zhu, Qing Xin

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: May 10, 2023

Abstract Background Alzheimer's disease (AD) is the leading cause of dementia in old age, recognized as a global health priority. The number patients projected to reach 152 million worldwide by mid-century. AD can damage thought, memory, and independence, increasing risk dependence, disability, mortality. aim present study explore precise causality from fruit intake on AD. Methods To causal effect fresh dried liability AD, this utilized genome-wide association (GWAS) developed MRC-IEU for full UK Biobank GWAS FinnGen round 8 conduct Mendelian randomization (MR) analysis. instrumental variables (IVs) each were selected based InSIDE hypothesis exposure-outcome datasets harmonized. used inverse variance weighted (IVW), MR‒Egger, median (WM) approaches MR estimates, scatter plots, funnel leave-one-out plots generated statistical inspection stability results. Results analyses conducted investigate effects using targeted datasets. Little evidence suggested potential relationship between (OR (95%CI) = 0.97 (0.50, 1.91), P-value 0.939), while significant intensive was indicated 4.09 (2.07, 8.10), < 0.001). Stability evaluations showed no heterogeneity pleiotropy affecting interpretability credibility primary analyses. Conclusions We strengthened supporting positive Alzheimer’s disease, failed be demonstrated. Further validation focusing underlying molecular mechanisms expansility ethnicity could strengthen reliability diet intervention throughout prevention

Language: Английский

Citations

0