Slovenian Medical Journal,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 8
Published: Feb. 24, 2024
Izhodišča:
SARS-CoV-2,
ki
povzroča
bolezen
covid-19,
vstopa
v
celice
preko
receptorja
za
angiotenzin
konvertazo
2,
je
izražen
tudi
ščitnici.
Pri
okužbi
s
SARS-CoV-2
se
močno
odzove
imunski
sistem,
kar
bi
lahko
vplivalo
na
pojavnost
in
izraženost
avtoimunskih
bolezni
pri
genetsko
dovzetnih
posameznikih.
Zato
smo
želeli
raziskati
vpliv
epidemije
covida-19
Hashimotovega
tiroiditisa
(HT),
najpogostejša
avtoimunska
ščitnice.
Metode:
V
retrospektivno
klinično
raziskavo
zajeli
podatke
iz
zdravstvene
dokumentacije
4.844
bolnikov,
so
bili
prvič
pregledani
Ambulanti
ščitnice
Kliniki
nuklearno
medicino
UKC
Ljubljana
obdobju
11
mesecev
pred
epidemijo
covida-19,
4.084
mesecih
med
covida-19.
Po
opravljenem
kliničnem
pregledu,
ultrazvočnem
pregledu
laboratorijskih
meritvah
specialisti
postavili
diagnozo
ščitnične
bolezni.
Podatke
statistično
analizirali
z
Mann-Whitneyevim
testom
U
χ2.
Rezultati:
Med
ugotovili
značilno
večjo
hipotirotičnega
HT
(p=0,037)
brez
protiteles
(p=0,022),
ne
pa
hipertirotičnega
(p=0,673)
evtirotičnega
(p=0,653).
imeli
hipotirotični
bolniki
višjo
koncentracijo
tirotropina
(p=0,001),
hipertirotični
prostega
tiroksina
(p=0,002)
kot
njo.
Zaključek:
povečala
protiteles.
Hipotiroza
hipertiroza
zaradi
sta
bolj
izraženi
njo.
Frontiers in Endocrinology,
Journal Year:
2025,
Volume and Issue:
15
Published: Feb. 4, 2025
The
coronavirus
disease
2019
(COVID-19)
pandemic,
caused
by
the
severe
acute
respiratory
syndrome
2
(SARS-CoV-2)
virus,
has
presented
multifaceted
health
challenges.
COVID-19
primarily
targets
system
but
also
affects
multiple
organ
systems,
including
endocrine
system.
Emerging
evidence
suggests
interactions
between
thyroid
function,
phase
of
COVID-19,
and
prolonged
symptoms
known
as
post-COVID
sequalae
or
long
COVID.
Several
studies
have
reported
that
can
induce
dysfunction,
leading
to
conditions
such
thyroiditis
alterations
in
hormone
levels.
mechanisms
through
which
SARS-CoV-2
include
direct
viral
infection
cells,
thyroiditis,
causes
inflammation
transient
sustained
well
an
excessive
systemic
immune
response
(cytokine
storm).
This
is
associated
with
elevated
levels
cytokines,
IL-6,
disrupt
function
lead
nonthyroidal
illness
(NTIS).
Medications
administered
during
phase,
corticosteroids
antiviral
drugs,
impact
actions.
involvement
gland
COVID,
postacute
sequelae
infection,
area
not
defined,
potential
implications
for
understanding
managing
this
condition.
Persistent
low-grade
affecting
over
time
ongoing
exacerbate
pre-existing
conditions.
Viral
infections,
SARS-CoV-2,
trigger
worsen
autoimmune
diseases,
Hashimoto’s
Graves’
disease.
Long
COVID
may
hypothalamic–pituitary–adrenal
(HPA)
axis,
can,
turn,
affect
hypothalamic-pituitary-thyroid
(HPT)
abnormal
function.
review
was
designed
systematically
capture
recent
literature
on
COVID-19-related
dysfunction
adult
population,
prognostic
consequences
effects
patients
A
comprehensive
search
PubMed
EMBASE
databases
conducted.
systematic
performed
based
Preferred
Reporting
Items
Systematic
Reviews
Meta-Analyses
(PRISMA)
statement.
Study
quality
assessed
using
Critical
Appraisal
Skills
Programme
(CASP).
total
53
met
inclusion
criteria.
summarises
findings
provides
update
current
spectrum
disorders,
underscoring
complex
nature
its
far-reaching
impacts
human
health.
Frontiers in Endocrinology,
Journal Year:
2025,
Volume and Issue:
15
Published: Jan. 24, 2025
Introduction
Studies
assessing
longitudinal
changes
in
the
prevalence
of
autoimmune
thyroiditis
(AIT)
among
pediatric
population
are
limited.
During
COVID-19
era,
several
papers
proposed
a
rise
AIT
cases.
Our
study
aimed
to
analyze
thyroid
autoimmunity
(TA)
over
10-year
period
spanning
pre-pandemic
and
pandemic
years
who
regularly
screened
for
disturbances.
Materials
methods
This
single-center
retrospective
cohort
analyzed
data
from
1,361
children
young
adults
with
type
1
diabetes
(T1D)
treated
between
2013
2022
Hungary’s
largest
endocrinology
center.
Results
anti-thyroid
autoantibodies
(anti-thyroid
peroxidase/ATPO/and
antithyroglobulin/ATG/),
function
tests
(TFTs)
ultrasound
examinations
were
obtained.
Annual
rates
TA
ultrasound-proven
calculated.
Mean
(±
SD)
follow-up
was
4.7
2.8)
years.
The
overall
our
T1D
22.8%
([20.3;25.5],
310
cases)
significantly
more
girls
affected
(p<0.001).
From
2022,
rose
15.9%
20.6%
(p=0.041).
increase
detected
during
but
not
era.
Ultrasound-confirmed
present
80.0%
examined
Ultrasound
positivity
rate
stable
period.
Among
TA,
28.5%
exhibited
clinically
relevant
thyroid-stimulating
hormone
(TSH)
abnormalities
(most
commonly
subclinical
hypothyroidism)
and/or
prescribed
medication.
Children
had
elevated
risk
dysfunction
compared
those
only
autoantibody
Conclusion
results
show
past
decade,
do
support
assumed
role
SARS-CoV-2
development
disease.
Frontiers in Molecular Biosciences,
Journal Year:
2025,
Volume and Issue:
12
Published: Feb. 25, 2025
The
ongoing
post-COVID-19
syndrome
(PCS)
epidemic,
causing
complications
of
diverse
etiology,
necessitates
the
search
for
new
diagnostic
markers
and
development
widely
accessible
methods
their
detection.
This
would
enable
prognosis
PCS
progression
faster
implementation
targeted
treatments.
One
potential
marker
is
neutrophil
elastase
(NE),
whose
elevated
levels
in
blood
during
may
result
from
organ
damage
caused
by
increased
secretion
severe
inflammatory
mediators
or
amyloidosis
resulting
interaction
NE
with
SARS-CoV-2.
aim
this
publication
to
present
a
step-by-step
method
designing
an
enzymatic
ELISA
test,
enabling
quantitative
assessment
serum
patients.
was
measured
using
designed
test.
study
outlines
all
steps
necessary
optimizing
including
selection
standards,
primary
secondary
antibodies,
dilutions.
Using
were
demonstrated
patients
advanced-stage
diabetic
nephropathy
after
symptomatic
COVID-19,
compared
relative
group
sampled
before
COVID-19.
undertaken
efforts
enabled
test
high
performance
parameters
(initially
set
sensitivity:
≥40
pg/μL;
intra-assay
precision:
7%;
inter-assay
precision
<20%).
No
significant
cross-reactivity
other
tested
proteins
observed.
Serial
dilution
plasma
samples
resulted
proportional
decrease
signal
intensity.
Frontiers in Endocrinology,
Journal Year:
2025,
Volume and Issue:
16
Published: May 19, 2025
The
literature
is
rapidly
evolving
with
regards
to
the
endocrine
consequences
of
coronavirus
disease
2019
(COVID-19),
including
diabetes,
thyroid
dysfunction,
adrenal
and
pituitary
disorders.
There
evidence
suggesting
that
severe
acute
respiratory
syndrome
2
(SARS-CoV-2)
infection
can
lead
dysfunction
long-term
sequelae.
We
aimed
review
current
propose
a
preventive
approach
based
on
published
data
since
beginning
COVID-19
pandemic.
A
comprehensive
was
conducted
using
electronic
databases
PubMed
Google
Scholar.
Two
authors
independently
used
keywords
"Thyroid,
Hypothyroidism,
Hyperthyroidism,
Graves,
Thyroid
Eye
Disease,
or
Thyroiditis"
"Coronavirus,
SARS-CoV-2
COVID-19"
search
these
databases.
screened
titles
abstracts
for
initial
selection
then
reviewed
full
text
relevant
studies
report
outcomes
data.
selected
28
manuscripts.
appears
similar
other
viruses.
It
affects
function
resulting
in
non-thyroidal
illness
syndrome,
which
usually
resolves
spontaneously.
also
causes
subacute
thyroiditis.
may
trigger
autoimmunity
against
leads
autoimmune
Autoimmune
thyroiditis
progress
clinical
subclinical
hypothyroidism
hyperthyroidism.
Patients
pre-existing
probably
have
risks
related
adverse
outcomes.
Evaluation
important
patients.
Improving
efficacy
treatment
reduce
short-term
complications.
https://www.crd.york.ac.uk/prospero,
identifier
CRD42023447994.
Diabetes/Metabolism Research and Reviews,
Journal Year:
2024,
Volume and Issue:
40(5)
Published: June 5, 2024
Abstract
Aims
This
study
reports
the
prevalence
and
characteristics
related
to
development
of
thyroid
autoimmunity
among
children
newly
diagnosed
with
type
I
diabetes
(T1D)
during
COVID‐19
pandemic
in
Kuwait.
Materials
Methods
is
a
prospective
observational
all
under
age
14
years
T1D
We
define
duration
from
official
declaration
first
identified
positive
case
on
24
February
2020
until
31
December
2022.
For
comparison,
we
use
time
period
directly
before
pandemic,
1
January
2017
23
2020.
Results
One
thousand
twenty‐four
(1024)
Kuwait
were
included.
Among
children,
20.3%
tested
for
antibodies
compared
14.5%
pre‐pandemic
(
p
=
0.015).
Children
status
more
likely
present
0.035).
After
adjusting
other
characteristics,
patients
had
double
odds
testing
(Adjusted
ratio
2.173,
95%CI:
1.108,
4.261,
0.024).
Conclusions
Incident
cases
may
be
different
aetiology
or
contextual
factors
leading
higher
risk
autoimmunity.
Longitudinal
studies
are
needed
understand
role
onset
progression
disease.
Current Oncology,
Journal Year:
2024,
Volume and Issue:
31(10), P. 6267 - 6269
Published: Oct. 17, 2024
Thyroid
cancer
is
relatively
rare
in
the
general
population
compared
to
other
malignancies,
but
its
incidence
appears
have
increased
recent
decades
[...]
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(21), P. 11624 - 11624
Published: Oct. 29, 2024
Extensive
research
has
been
conducted
on
the
SARS-CoV-2
virus
in
association
with
various
infectious
diseases
to
understand
pathophysiology
of
infection
and
potential
co-infections.
In
tropical
countries,
exposure
local
viruses
may
alter
course
coinfection.
Notably,
only
a
portion
antibodies
produced
against
proteins
demonstrate
neutralizing
properties,
immune
response
following
natural
tends
be
temporary.
contrast,
long-lasting
IgG
are
common
after
dengue
infections.
cases
where
preexisting
from
an
initial
bind
different
serotype
during
subsequent
infection,
there
is
for
antibody-dependent
enhancement
(ADE)
formation
complexes
associated
disease
severity.
Both
infections
can
result
immunodeficiency.
Viral
both
interfere
host's
IFN-I
signaling.
Additionally,
cytokine
storm
occur
viral
impairing
proper
response,
autoantibodies
wide
array
appear
convalescence.
Most
reported
typically
short-lived.
Vaccines
affecting
enhancing
clearance.
A
comprehensive
analysis
pathogenicity
revisited
prevent
severity,
mortality.