Nutrients,
Journal Year:
2024,
Volume and Issue:
16(24), P. 4299 - 4299
Published: Dec. 12, 2024
Universal
salt
iodisation
(USI)
plays
an
essential
role
in
the
provision
of
iodine
(I)
to
populations
worldwide.
Countries
adopting
USI
programmes,
adhering
strict
criteria
laid
down
by
expert
organisations
such
as
Iodine
Global
Network,
are
estimated
have
reduced
prevalence
I
deficiency
75%
(protecting
720
million
individuals
worldwide).
Despite
this
success,
doubts
been
raised
desirability
continuing
programmes
because
(a)
need
reduce
intake
for
cardiovascular
prevention
and
(b)
induction
thyroid
autoimmunity.
We
present
current
evidence
from
cross-sectional
studies
several
disparate
possible
short-term
modulation
autoimmune
markers,
peroxidase
(TPOAb)
thyroglobulin
antibodies
(TgAb),
with
minimal
disruption
biochemical
function.
also
longer
term,
mainly
studies,
that
indicate
a
reduction
TPOAb
TgAb,
persistence
normal
function
over
long
two
decades
USI.
believe
these
is
safe,
long-term
does
not
cause
increase
disease
studied
should
be
safety
concern
based
on
evidence.
More
better-designed
required.
Ecotoxicology and Environmental Safety,
Journal Year:
2024,
Volume and Issue:
281, P. 116604 - 116604
Published: June 18, 2024
Irritable
bowel
syndrome
(IBS)
patients
exhibit
significantly
lower
levels
of
serum
selenium
(Se)
compared
to
healthy
controls.
This
study
integrates
a
prospective
cohort
analysis
and
animal
experiments
investigate
Se
deficiency
as
potential
risk
factor
for
IBS.
Using
data
from
the
UK
Biobank,
longitudinal
was
conducted
explore
associations
between
dietary
intake
incident
In
study,
C57BL/6
mice
were
fed
diets
with
normal
(0.2
ppm)
or
low
(0.02
assess
impacts
on
IBS
symptoms.
Furthermore,
we
performed
16
S
rRNA
sequencing,
untargeted
colonic
fecal
metabolomics
analysis,
colon
transcriptome
profiling
uncover
regulatory
mechanisms
underlying
deficiency-induced
The
Biobank
revealed
significant
correlation
an
increased
incidence
experimental
diet
induced
symptoms,
evidenced
by
elevated
abdominal
withdrawal
reflex
scores,
inflammation,
severe
pathological
damage
colon.
Additionally,
caused
disturbances
in
gut
microbiota,
characterized
increase
Faecalibaculum
Helicobacter,
decrease
Bifidobacterium
Akkermansia.
Combined
indicated
that
might
trigger
through
disruptions
pathways
related
"bile
excretion",
"steroid
hormone
biosynthesis",
"arachidonic
acid
metabolism",
"drug
metabolism-cytochrome
P450".
These
findings
underscore
adverse
effects
suggest
supplementation
should
be
considered
patients.
Journal of Agricultural and Food Chemistry,
Journal Year:
2024,
Volume and Issue:
72(44), P. 24808 - 24822
Published: Oct. 23, 2024
Selenium
regulates
the
differentiation
and
function
of
immune
cells
mainly
through
selenoproteins.
Selenoprotein
W
(SelW)
has
been
shown
to
mitigate
inflammatory
bowel
disease
in
mice
by
modulating
helper
T
(CD4
Frontiers in Endocrinology,
Journal Year:
2024,
Volume and Issue:
15
Published: Feb. 9, 2024
Background
Thyroid
autoimmunity
is
one
of
the
most
prevalent
autoimmune
diseases.
However,
its
association
with
extra-thyroid
diseases
and
mortality
risk
in
general
population
remains
uncertain.
Our
study
aims
to
evaluate
thyroid
disease
mortality.
Methods
A
prospective
cohort
was
conducted
using
data
from
National
Health
Nutrition
Examination
Survey
(NHANES)
participants
2007–2008,
2009–2010,
2011–2012,
tracking
their
until
2019.
Associations
between
autoimmunity,
which
defined
as
having
positive
peroxidase
antibody
(TPOAb)
and/or
thyroglobulin
(TgAb),
including
diabetes,
hypertension,
cardiovascular
disease,
chronic
lung
arthritis,
cancer
renal
were
investigated.
Results
total
7431
included
this
study.
Positive
The
prevalence
TgAb
7.54%,
TPOAb
11.48%.
significantly
associated
diabetes
(Model
1:
OR=1.64,
95%
CI:1.08-2.50;
Model
2:
OR=1.93,
CI:
1.21-3.08)
hypertension
OR=0.67,
0.49-0.91;
OR=0.62,
0.44-0.88).
a
lower
(model
OR=0.71,
0.54-0.95;
model
0.53-0.95).
No
associations
observed
TgAb,
other
Neither
nor
all-cause
or
heart
Conclusion
linked
higher
while
decreased
disease.
neither
posed
for
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(24), P. 4299 - 4299
Published: Dec. 12, 2024
Universal
salt
iodisation
(USI)
plays
an
essential
role
in
the
provision
of
iodine
(I)
to
populations
worldwide.
Countries
adopting
USI
programmes,
adhering
strict
criteria
laid
down
by
expert
organisations
such
as
Iodine
Global
Network,
are
estimated
have
reduced
prevalence
I
deficiency
75%
(protecting
720
million
individuals
worldwide).
Despite
this
success,
doubts
been
raised
desirability
continuing
programmes
because
(a)
need
reduce
intake
for
cardiovascular
prevention
and
(b)
induction
thyroid
autoimmunity.
We
present
current
evidence
from
cross-sectional
studies
several
disparate
possible
short-term
modulation
autoimmune
markers,
peroxidase
(TPOAb)
thyroglobulin
antibodies
(TgAb),
with
minimal
disruption
biochemical
function.
also
longer
term,
mainly
studies,
that
indicate
a
reduction
TPOAb
TgAb,
persistence
normal
function
over
long
two
decades
USI.
believe
these
is
safe,
long-term
does
not
cause
increase
disease
studied
should
be
safety
concern
based
on
evidence.
More
better-designed
required.
