Cardiac abnormalities pre- and post-liver transplantation for metabolic dysfunction-associated steatohepatitis – Evidence and special considerations DOI Creative Commons
Steven M. Elzein, Elizabeth W. Brombosz, Sudha Kodali

et al.

Journal of Liver Transplantation, Journal Year: 2024, Volume and Issue: 15, P. 100228 - 100228

Published: May 18, 2024

Metabolic dysfunction-associated steatotic liver disease (MASLD) has an alarmingly high global prevalence. Its progressive subtype, metabolic steatohepatitis (MASH), is the leading indication for transplantation overall. Although MASLD been associated with increased risk several cardiac abnormalities including arrhythmias, structural disease, heart failure, valvular and coronary artery little known about clinical course effects of these in post-liver transplant patients MASH as etiology their cirrhosis. This narrative review presents mechanistic evidence association aforementioned abnormalities, well characterizes what significance post-operative period those undergoing MASH. Additionally, this emphasizes knowledge gaps highlights areas further study impact

Language: Английский

Identification of common signature genes and pathways underlying the pathogenesis association between nonalcoholic fatty liver disease and heart failure DOI Creative Commons
Gerui Li,

Zhengjie Lu,

Ze Chen

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 16, 2024

Background Non-alcoholic fatty liver disease (NAFLD) and heart failure (HF) are related conditions with an increasing incidence. However, the mechanism underlying their association remains unclear. This study aimed to explore shared pathogenic mechanisms common biomarkers of NAFLD HF through bioinformatics analyses experimental validation. Methods HF-related transcriptome data were extracted from Gene Expression Omnibus (GEO) database (GSE126848 GSE26887). Differential analysis was performed identify differentially expressed genes (co-DEGs) between HF. ontology (GO), Kyoto Encyclopedia Genes Genomes (KEGG), gene set enrichment (GSEA) conducted functions regulatory pathways co-DEGs. Protein-protein interaction (PPI) network support vector machine-recursive feature elimination (SVM-RFE) methods used screen key DEGs. The diagnostic value DEGs assessed by receiver operating characteristic (ROC) curve validated external datasets (GSE89632 GSE57345). Finally, expression in mouse models. Results A total 161 co-DEGs screened out patients. GO, KEGG, GSEA indicated that these mainly enriched immune-related pathways. PPI revealed 14 DEGs, SVM-RFE model eventually identified two ( CD163 CCR1 ) as for levels significantly down-regulated ROC showed had good values NAFLD. Single-gene suggested engaged immune responses inflammation. Experimental validation unbalanced macrophage polarization models, down-regulated. Conclusion M2 impairment characterized decreased a pathway downregulation may reflect pathological changes development progression HF, suggesting potential therapeutic targets.

Language: Английский

Citations

3
Clinical utility of the Fibrosis-4 index for predicting mortality in patients with heart failure with or without metabolic dysfunction-associated steatotic liver disease: a prospective cohort study DOI Creative Commons
Joost Boeckmans, Jürgen H. Prochaska, Alexander Gieswinkel

et al.

The Lancet Regional Health - Europe, Journal Year: 2024, Volume and Issue: 48, P. 101153 - 101153

Published: Nov. 30, 2024

Language: Английский

Citations

3
The Cardiac-Kidney-Liver (CKL) syndrome: the “real entity” of type 2 diabetes mellitus DOI Creative Commons
Niki Katsiki, Genovefa Kolovou, Αndreas Μelidonis

et al.

Archives of Medical Science, Journal Year: 2024, Volume and Issue: 20(1), P. 207 - 215

Published: Jan. 31, 2024

1. Davies MJ, D'Alessio DA, Fradkin J, et al. Management of hyperglycemia in type 2 diabetes, 2018. A Consensus Report by the American Diabetes Association (ADA) and European for Study (EASD). Care 2018; 41: 2669–701. Google Scholar

Language: Английский

Citations

2
Non-alcoholic fatty liver disease and risk of cardiovascular diseases: clinical association, pathophysiological mechanisms, and management DOI Creative Commons
Rong Yang, Jian‐Gao Fan

Cardiology Plus, Journal Year: 2023, Volume and Issue: 8(4), P. 217 - 226

Published: Oct. 1, 2023

Non-alcoholic fatty liver disease (NAFLD) is a associated with metabolic dysfunction in genetically susceptible individuals due to over-nutrition and lack of exercise. With the prevalence obesity, syndrome, type 2 diabetes mellitus, NAFLD has become most common cause chronic worldwide. shares many risk factors cardiovascular diseases (CVDs). increased major events other cardiac complications even after adjustment for traditional factors. The primary pathology within liver, but deaths patients CVDs. This review summarizes epidemiological evidence association between CVD pathophysiological mechanisms underlying this association. Current treatment strategies their potential impact on are also discussed.

Language: Английский

Citations

1
Metabolic Dysfunction-Associated Steatotic Liver Disease and Heart Failure with Preserved Ejection Fraction: A Bidirectional Relationship with Clinical and Therapeutic Implications DOI Creative Commons
Ana Rita Leite,

João Carlos Pinto Dias,

T Godinho

et al.

Deleted Journal, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 17

Published: Sept. 18, 2024

Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is increasingly prevalent and the most common cause of chronic in western world. It considered hepatic manifestation metabolic syndrome ultimately leads to cardiovascular diseases, which are leading death. Heart failure with preserved ejection fraction (HFpEF) appears be a complication MASLD and, conversely, seems exacerbate its severity. This review focuses on pathophysiological association between HFpEF, as well their clinical therapeutic implications. Summary: The connection HFpEF intricate bidirectional, involving several mechanisms, such insulin resistance, overactivation renin-angiotensin-aldosterone sympathetic nervous systems, systemic inflammation, gut dysbiosis. an independent risk factor for diastolic dysfunction increasing hospitalization death those established heart failure. Conversely, exacerbates severity MASLD. Screening fibrosis should conducted stable euvolemic patients utilizing ultrasonography Fibrosis-4 index. performed measurement natriuretic peptides; however, these may have lower sensitivity echocardiography needed. Therapeutic strategies both limited, but certain interventions studied also benefit system. Lifestyle interventions, adherence Mediterranean diet weight loss, proven beneficial diseases. Sodium-glucose cotransporter 2 inhibitors (SGLT2i) incretin mimetics show promise treating conditions synergistic effects. Key Messages: increases incident worsens prognosis HFpEF. Given high prevalence screening crucial. begin peptides when there suspicion. SGLT2i glucagon-like peptide-1 receptor agonists offer benefits

Language: Английский

Citations

0
Cardiac abnormalities pre- and post-liver transplantation for metabolic dysfunction-associated steatohepatitis – Evidence and special considerations DOI Creative Commons
Steven M. Elzein, Elizabeth W. Brombosz, Sudha Kodali

et al.

Journal of Liver Transplantation, Journal Year: 2024, Volume and Issue: 15, P. 100228 - 100228

Published: May 18, 2024

Metabolic dysfunction-associated steatotic liver disease (MASLD) has an alarmingly high global prevalence. Its progressive subtype, metabolic steatohepatitis (MASH), is the leading indication for transplantation overall. Although MASLD been associated with increased risk several cardiac abnormalities including arrhythmias, structural disease, heart failure, valvular and coronary artery little known about clinical course effects of these in post-liver transplant patients MASH as etiology their cirrhosis. This narrative review presents mechanistic evidence association aforementioned abnormalities, well characterizes what significance post-operative period those undergoing MASH. Additionally, this emphasizes knowledge gaps highlights areas further study impact

Language: Английский

Citations

0