Evaluating Circulating Biomarkers for Diagnosis, Prognosis, and Tumor Monitoring in Pediatric Sarcomas: Recent Advances and Future Directions DOI Creative Commons
Joaquín J. Maqueda, Alessandra De Feo, Katia Scotlandi

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(10), P. 1306 - 1306

Published: Oct. 16, 2024

Pediatric sarcomas present a significant challenge in oncology. There is an urgent need for improved therapeutic strategies high-risk patients and better management of long-term side effects those who survive the disease. Liquid biopsy emerging as promising tool to optimize treatment these by offering non-invasive, repeatable assessments disease status. Circulating biomarkers can provide valuable insights into tumor genetics response, potentially facilitating early diagnosis dynamic monitoring. This review examines potential liquid biopsies, focusing on circulating most common pediatric sarcomas, i.e., osteosarcoma, Ewing sarcoma, rhabdomyosarcoma. We also highlight current research efforts necessary advancements required before technologies be widely adopted clinical practice.

Language: Английский

Extracellular Vesicles as Next-Generation Diagnostics and Advanced Therapy Medicinal Products DOI Open Access
Agnieszka Stawarska, Magdalena Bamburowicz‐Klimkowska, Elise Rundén‐Pran

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(12), P. 6533 - 6533

Published: June 13, 2024

Extracellular vesicles (EVs) hold great promise for clinical application as new diagnostic and therapeutic modalities. This paper describes major GMP-based upstream downstream manufacturing processes EV large-scale production, also focusing on post-processing technologies such surface bioengineering uploading studies to yield novel EV-based diagnostics advanced therapy medicinal products. focuses the quality, safety, efficacy issues of bioengineered drug candidates before first-in-human studies. Because trials involving extracellular are global rise, this encompasses different registered clinical-trial register platforms, with varying levels advancement, highlighting growing interest in EV-related programs. Navigating regulatory affairs EVs poses real challenges, obtaining marketing authorization medicines remains complex due lack specific guidelines discusses state-of-the-art knowledge date products, further research needs safe reliable implementation tools settings. Post-marketing pharmacovigilance products is presented, mainly addressing topics risk assessment management.

Language: Английский

Citations

13
Research progress in Alzheimer's disease and bone-brain axis DOI Creative Commons
Fan Zhang, Wei Zhang

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 98, P. 102341 - 102341

Published: May 15, 2024

Alzheimer's disease (AD) is the most common type of cognitive impairment. AD closely related to orthopedic diseases, such as osteoporosis and osteoarthritis, in terms epidemiology pathogenesis. Brain bone tissues can regulate each other different manners through bone-brain axis. This article reviews research progress relationship between axis mechanisms AD, therapy by targeting axis, order deepen understanding communication, promote early diagnosis explore new for patients. Keywords

Language: Английский

Citations

6
Prevalence and plasma exosome-derive microRNA diagnostic biomarker screening of adolescent idiopathic scoliosis in Yunnan Province, China DOI Creative Commons

Ping Yuan,

Zhihua Wang,

Hong Jiang

et al.

Frontiers in Pediatrics, Journal Year: 2024, Volume and Issue: 12

Published: April 24, 2024

Idiopathic scoliosis significantly affects the physical and mental health of children adolescents, with varying prevalence rates in different regions. The occurrence idiopathic is associated genetic regulation biochemical factors, but changes exosome-derived miRNA profiles among patients remain unclear. This study aimed to determine Yunnan Province, China, identify key miRNAs through a cohort study.

Language: Английский

Citations

4
Therapeutic applications of miRNA in the management of obesity and osteoporosis DOI Creative Commons
Sakhavat Abolhasani, Yasin Ahmadi,

Yavar Rostami

et al.

Journal of Diabetes & Metabolic Disorders, Journal Year: 2025, Volume and Issue: 24(1)

Published: March 3, 2025

Obesity and osteoporosis are interrelated global health challenges, both characterized by dysregulated bone metabolism adipose tissue dynamics, contributing to increased fracture risk systemic complications. Emerging evidence underscores the pivotal role of microRNAs (miRNAs) as regulatory molecules governing intricate balance between adipogenesis osteogenesis, thereby providing a molecular link these two conditions. Both disorders alterations in which increase fractures Recent advancements biology have identified miRNAs crucial regulators disorders, influencing differentiation marrow mesenchymal stem cells (BMSCs) into osteoblasts (bone-forming cells) adipocytes (fat-storing cells). This review provides comprehensive analysis dual modulating osteogenesis adipogenesis, with particular focus on their implications disease progression therapeutic strategies. It first explores how specific regulate critical energy metabolism, inflammation, remodeling pathways. By integrating insights from biology, endocrinology, clinical practice, highlights potential miRNA-based interventions. Targeting could restore offering innovative approaches simultaneously address obesity osteoporosis. These proposed strategies hold promise for improving patient outcomes mitigating risk, enhancing density, addressing metabolic dysfunctions associated obesity. Ultimately, future research should translating applications develop effective therapies that tackle complex interplay prevalent

Language: Английский

Citations

0
A bibliometric and visualized analysis of extracellular vesicles in degenerative musculoskeletal diseases (from 2006 to 2024) DOI Creative Commons
Junjie Yang,

Sen He,

Bei Huang

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: March 13, 2025

Background With the rapid development of extracellular vesicles (EVs) in regenerative medicine research, they have become a promising new direction mechanistic, diagnosis and treatment studies degenerative musculoskeletal diseases (DMDs), has attracted increasing attention. However, there is currently lack comprehensive objective summary analysis to help researchers quickly conveniently understand trajectory future trends this field. Method This study collected articles reviews published from 2006 2024 on EVs DMDs Web Science database. Bibliometric visual was conducted using several tools, including Microsoft Excel Office, VOSviewer, CiteSpace, Pajek, R packages. Results 1,182 publications were included 2024. Notably, increase number starting 2016, suggesting that field remains developmental stage. Co-authorship revealed China ranked first terms publications, whereas United States led citations. The journal with highest International Journal Molecular Sciences (INT J MOL SCI). most prolific authors Ragni, E 23 while cited author Toh, WS. Additionally, nine top 10 institutions China, Shanghai Jiao Tong University leading publications. article “MSC exosomes mediate cartilage repair by enhancing proliferation, attenuating apoptosis modulating immune reactivity”, authored Zhang, S, BIOMATERIALS 2018. Conclusion study, through bibliometric analysis, clearly illustrates collaborative relationships among countries, authors, institutions, journals, providing valuable insights for seeking academic collaboration opportunities. Moreover, keywords citations allows better key research hotspots frontiers field, points toward directions research. growing interest EV over recent years indicates attention dynamic progression

Language: Английский

Citations

0
Machine learning and experimental analyses identified miRNA expression models associated with metastatic osteosarcoma DOI

Samira Abedi,

Ali Behmanesh,

Farid Najd Mazhar

et al.

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Journal Year: 2024, Volume and Issue: 1870(7), P. 167357 - 167357

Published: July 20, 2024

Language: Английский

Citations

1
Functional Mechanism and Clinical Implications of lncRNA LINC-PINT in Delayed Fracture Healing DOI Creative Commons
Xiaoyu Ma, Xin Qian, Rong Ren

et al.

Journal of Investigative Surgery, Journal Year: 2024, Volume and Issue: 37(1)

Published: Oct. 28, 2024

Fracture healing can be impeded or even compromised by various factors, resulting in a growing number of patients suffering. The lncRNA LINC-PINT has garnered attention for its latent role enhancing fracture healing, but specific functions this process remain unclear.

Language: Английский

Citations

1
DEJKMDR: miRNA-disease association prediction method based on graph convolutional network DOI Creative Commons

Shiyuan Gao,

Zhufang Kuang, Tao Duan

et al.

Frontiers in Medicine, Journal Year: 2023, Volume and Issue: 10

Published: Sept. 12, 2023

Numerous studies have shown that miRNAs play a crucial role in the investigation of complex human diseases. Identifying connection between and diseases is for advancing treatment However, traditional methods are frequently constrained by small sample size high cost, so computational simulations urgently required to rapidly accurately forecast potential correlation miRNA disease. In this paper, DEJKMDR, graph convolutional network (GCN)-based miRNA-disease association prediction model proposed. The novelty lies fact DEJKMDR integrates biomolecular information on illness, including functional similarity, disease semantic according their Gaussian interaction attribute. order minimize overfitting, some edges randomly destroyed during training phase after DropEdge has been used regularize edges. JK-Net, meanwhile, employed combine various domain scopes through adaptive learning nodes placements. experimental results demonstrate strategy superior accuracy dependability than previous algorithms terms predicting an unknown relationship. 10-fold cross-validation, average AUC determined be 0.9772.

Language: Английский

Citations

2
Inflammatory biomarkers of osteosarcopenia in community-dwelling older woman DOI Creative Commons
Leonardo Teixeira, Luana Aparecida Soares, Adriana Netto Parentoni

et al.

Clinical Nutrition Open Science, Journal Year: 2024, Volume and Issue: 55, P. 173 - 182

Published: March 29, 2024

Language: Английский

Citations

0
From Genesis to Old Age: Exploring the Immune System One Cell at a Time with Flow Cytometry DOI Creative Commons
Anis Larbi

Biomedicines, Journal Year: 2024, Volume and Issue: 12(7), P. 1469 - 1469

Published: July 3, 2024

The immune system is a highly complex and tightly regulated that plays crucial role in protecting the body against external threats, such as pathogens, internal abnormalities, like cancer cells. It undergoes development during fetal stages continuously learns from each encounter with allowing it to develop immunological memory provide wide range of protection. Over time, after numerous encounters years functioning, can begin show signs erosion, which commonly named immunosenescence. In this review, we aim explore how responds initial antigens handles persistent stimulations throughout person's lifetime. Our understanding has greatly benefited advanced technologies flow cytometry. context, will discuss valuable contribution cytometry enhancing our knowledge behavior aging, specific focus on T-cells. Moreover, expand discussion cytometry-based assessment extracellular vesicles, recently discovered communication channel biology, their implications for functioning.

Language: Английский

Citations

0