iScience, Journal Year: 2024, Volume and Issue: 28(2), P. 111699 - 111699
Published: Dec. 28, 2024
Language: Английский
Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)
Published: Feb. 16, 2024
Abstract The human gastrointestinal tract is populated with a diverse microbial community. vast genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every aspect biology, including health maintenance, development, aging, disease. advent new sequencing technologies culture-independent methods has allowed researchers to move beyond correlative studies toward mechanistic explorations shed light on microbiome–host interactions. Evidence unveiled bidirectional communication between central nervous system, referred as “microbiota–gut–brain axis”. microbiota–gut–brain axis represents an important regulator glial functions, making it actionable target ameliorate development progression neurodegenerative diseases. In this review, we discuss mechanisms As provides essential cues microglia, astrocytes, oligodendrocytes, examine communications microbiota these cells during healthy states Subsequently, diseases using metabolite-centric approach, while also examining role microbiota-related neurotransmitters hormones. Next, targeting intestinal barrier, blood–brain meninges, peripheral immune system counteract dysfunction neurodegeneration. Finally, conclude by assessing pre-clinical clinical evidence probiotics, prebiotics, fecal transplantation A thorough comprehension will foster effective therapeutic interventions for management
Language: Английский
Citations
255
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: Jan. 30, 2024
Introduction Recent evidence supports the contribution of gut microbiota dysbiosis to pathophysiology rheumatic diseases, neuropathic pain, and neurodegenerative disorders. The bidirectional gut-brain communication network occurrence chronic pain both involve contributions autonomic nervous system hypothalamic pituitary adrenal axis. Nevertheless, current understanding association between is still not clear. Therefore, aim this study systematically evaluate existing knowledge about alterations in conditions. Methods Four databases were consulted for systematic literature review: PubMed, Web Science, Scopus, Embase. Newcastle-Ottawa Scale was used assess risk bias. protocol prospectively registered at International prospective register reviews (PROSPERO, CRD42023430115). Alpha-diversity, β-diversity, relative abundance different taxonomic levels summarized qualitatively, quantitatively if possible. Results initial database search identified a total 3544 unique studies, which 21 studies eventually included review 11 meta-analysis. Decreases alpha-diversity revealed patients compared controls several metrics: observed species (SMD= -0.201, 95% CI from -0.04 -0.36, p=0.01), Shannon index -0.27, -0.11 -0.43, p<0.001), faith phylogenetic diversity (SMD -0.35, -0.08 -0.61, p=0.01). Inconsistent results beta-diversity. A decrease Lachnospiraceae family, genus Faecalibacterium Roseburia , prausnitzii Odoribacter splanchnicus as well an increase Eggerthella spp., controls. Discussion Indications patients, with non-specific disease microbes. Systematic registration https://www.crd.york.ac.uk/prospero/ identifier CRD42023430115.
Language: Английский
Citations
21
Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 15
Published: Jan. 17, 2025
Obesity is a major modifiable risk factor leading to neuroinflammation and neurodegeneration. Excessive fat storage in obesity promotes the progressive infiltration of immune cells into adipose tissue, resulting release pro-inflammatory factors such as cytokines adipokines. These inflammatory mediators circulate through bloodstream, propagating inflammation both periphery central nervous system. Gut dysbiosis, which results leaky intestinal barrier, exacerbates plays significant role linking pathogenesis neurodegeneration gut-brain/gut-brain-liver axis. Inflammatory states within brain can lead insulin resistance, mitochondrial dysfunction, autolysosomal increased oxidative stress. disruptions impair normal neuronal function subsequently cognitive decline motor deficits, similar pathologies observed neurodegenerative diseases, including Alzheimer's disease, multiple sclerosis, Parkinson's disease. Understanding underlying disease mechanisms crucial for developing therapeutic strategies address defects these metabolic pathways. In this review, we summarize provide insights different strategies, methods alter gut lifestyle changes, dietary supplementation, well pharmacological agents derived from natural sources, that target obesity-induced
Language: Английский
Citations
3
Gut, Journal Year: 2024, Volume and Issue: 73(12), P. 1934 - 1943
Published: May 22, 2024
Puerarin (PU) is a natural compound that exhibits limited oral bioavailability but has shown promise in the treatment of atherosclerosis (AS). However, precise mechanisms underlying its therapeutic effects remain incompletely understood. This study aimed to investigate PU and mitigating AS both mice humans.
Language: Английский
Citations
13
Pharmacological Research, Journal Year: 2024, Volume and Issue: 208, P. 107398 - 107398
Published: Sept. 4, 2024
Language: Английский
Citations
11
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(3), P. 1803 - 1803
Published: Feb. 2, 2024
Obesity, a chronic condition marked by the excessive accumulation of adipose tissue, not only affects individual well-being but also significantly inflates healthcare costs. The physiological excess fat manifests as triglyceride (TG) deposition within with white tissue (WAT) expansion via adipocyte hyperplasia being key adipogenesis mechanism. As efforts intensify to address this global health crisis, understanding complex interplay contributing factors becomes critical for effective public interventions and improved patient outcomes. In context, gut microbiota-derived metabolites play an important role in orchestrating obesity modulation. Microbial lipopolysaccharides (LPS), secondary bile acids (BA), short-chain fatty (SCFAs), trimethylamine (TMA) are main intestinal dyslipidemic states. Emerging evidence highlights microbiota’s substantial influencing host metabolism subsequent outcomes, presenting new avenues therapeutic strategies, including polyphenol-based manipulations these microbial populations. Among various agents, caffeine emerges potent modulator metabolic pathways, exhibiting anti-inflammatory, antioxidant, obesity-mitigating properties. Notably, caffeine’s anti-adipogenic potential, attributed downregulation regulators, has been established. Recent findings further indicate that influence on may be mediated through alterations microbiota its byproducts. Therefore, present review summarizes effect modulating metabolites.
Language: Английский
Citations
9
Nutrition Reviews, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 28, 2025
Abstract The gut microbiome is a complex system that directly interacts with and influences many systems in the body. This delicate balance of microbiota plays an important role health disease highly influenced by lifestyle factors surrounding environment. As further research emerges, understanding full potential impact using nutraceuticals to positively influence its function may open door greater therapeutic outcomes treatment prevention disease. Curcumin, bioactive compound derived from turmeric rhizome, has been studied depth for on human as potent anti-inflammatory antioxidant properties. However, activity curcumin limited low oral bioavailability. While most available primarily focused curcuminoid compounds turmeric, non-curcuminoid hold promise offer benefits while synergistically enhancing bioavailability supporting microbiome. review summarizes current knowledge relationship between various within body, how dysbiosis, or disruption microbial balance, leads inflammation increased risk chronic also recent focuses bioactivity both comprise whole root their synergistic support healthy promising use
Language: Английский
Citations
1
Archives of Biochemistry and Biophysics, Journal Year: 2025, Volume and Issue: unknown, P. 110341 - 110341
Published: Feb. 1, 2025
Language: Английский
Citations
1
Foods, Journal Year: 2024, Volume and Issue: 13(22), P. 3529 - 3529
Published: Nov. 5, 2024
Obesity is a pandemic currently affecting the world's population that decreases quality of life and promotes development chronic non-communicable diseases.
Language: Английский
Citations
5
Published: Nov. 7, 2024
Magnesium (Mg) is not prominent among the list of well known anti-aging agents. Yet signs and symptoms aging mimic those Mg deficiency. required for over 800 enzymatic reactions (as 2022). This review does correlate status with clinical data on agents linked to longevity. The approach physiologic highlights specific dependent by these longevity biomarkers. Many share common pathways extend healthspan. a cofactor in synthesis vitamin D melatonin activation six eight B vitamins. It all CYP450 enzymes. directly responsible appropriate methylation proteins DNA, which control epigenome. MTHFR (methylenetetrahydrofolate reductase) 677T allele that compromises present majority Americans. Aberrant predicts severity Covid-19 its persistence into long Covid. silent benefactor may indirectly link agents, but only if viewed context calcium (Ca), i.e., Ca:Mg. Both compete same receptor. To fully exploit sufficient required. pertinent physiology presented.
Language: Английский
Citations
5