Clinical and anamnestic features of rosacea in women in perimenopausal period

Russian Journal of Clinical Dermatology and Venereology, Journal Year: 2025, Volume and Issue: 24(1), P. 49 - 49

Published: Feb. 25, 2025

Background. Perimenopausasal transition in women is characterized by vasomotor and psychoemotional symptoms, sleep disturbance, development of genitourinary menopausal syndrome, dermatological problems that together worsen the quality life determine medico-social significance problem. Rosacea, which based on vascular pathomorphological pathophysiological changes occurring presence already existing somatic diseases, one frequent dermatoses perimenopausal period. Objective — assessment clinical anamnestic characteristics period, suffering from rosacea. Material methods. The study involved 97 patients with rosacea, mean age 50.0±2.7 years. control group included 60 women, 49.0±2.5 Within group, an additional division into 2 subgroups (pre- postmenopausal period) was carried out. All groups were examined physical examination, obstetric-gynecological, thrombotic history studied. Results. Patients rosacea statistically significantly more often had stage I—II arterial hypertension (OR 2.51, p=0.0377) chronic diseases appendages 4.89, p=0.0405) regardless transition. Subjects period predominantly moderate severe papulopustular subtype (p=0.0516), while preserved menstrual function likely to have erythematotelangiectatic (p=0.0516) a predominance mild severity disease’s course (p=0.0506). Conclusion. obtained data show different depending indicate need for comprehensive medical further monitoring allied specialists achieve optimal therapeutic outcome.

Language: Английский

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The Role of Hypoxia-Inducible Factor-1α (HIF-1α) in the Progression of Ovarian Cancer: Perspectives on Female Infertility

Cells, Journal Year: 2025, Volume and Issue: 14(6), P. 437 - 437

Published: March 14, 2025

Hypoxia-Inducible Factor-1α (HIF-1α) is crucial in the progression of ovarian cancer, especially influencing its tumor microenvironment and promoting pathogenic pathways that worsen female infertility. In hypoxic settings, HIF-1α stabilized activates transcription genes associated with angiogenesis, metabolic reprogramming, epithelial-to-mesenchymal transition, therapeutic resistance. Angiogenesis glycolytic reprogramming mediated by HIF-1 proliferation, survival, metastasis. Its dysfunction concurrently impairs homeostasis, undermining follicular growth, hormone synthesis, vascular network, consequently contributing to Moreover, induces persistent inflammation oxidative stress, an environment damaging reproductive health. Due dual function cancer growth infertility, a potential target. Strategies including small molecule inhibitors nanoparticle-mediated delivery drugs possess reduce activity, hence reducing while protecting fertility. This review seeks clarify molecular basis effects on providing insights into novel treatment approaches target both controlling disease preserving

Language: Английский

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Epigenetic Alterations in Ovarian Function and Their Impact on Assisted Reproductive Technologies: A Systematic Review

Biomedicines, Journal Year: 2025, Volume and Issue: 13(3), P. 730 - 730

Published: March 17, 2025

Background: Epigenetic modifications have an important role in controlling ovarian function, modulating response and implantation success Assisted Reproductive Technologies (ART). The alterations, such as DNA methylation non-coding RNA control, been identified key variables regulating physiology reproductive outcomes. This systematic review investigates the significance of epigenetic pathways with emphasis on their effect ART rates. Methods: A thorough search PubMed, Scopus, EMBASE databases was performed to find articles published between 2015 2024 that investigated connection changes function patients. Studies examined miRNA expression, methylation, histone follicular fluid, granulosa cells, embryos were included. study followed PRISMA recommendations guarantee scientific rigor repeatability. data combined into a markers linked aging, reserve, success. Results: total 15 studies satisfied inclusion criteria, substantial relationships found distinct function. Changes expression patterns fluid cells associated oocyte maturation, potential. Women low reserve polycystic ovary syndrome (PCOS) different patterns. MiR-27a-3p miR-15a-5p shown be involved cell malfunction poor response, whereas global hypomethylation aging results. Conclusions: alterations affect via control hormone signaling, development, Further is needed determine practical applicability biomarkers predicting effectiveness enhancing patient treatment procedures.

Language: Английский

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Overview of Nrf2 as a target in ovary and ovarian dysfunctions focusing on its antioxidant properties

Journal of Ovarian Research, Journal Year: 2025, Volume and Issue: 18(1)

Published: March 22, 2025

Female infertility is a common issue caused by various factors, such as hormonal imbalances, age-related decline in oocyte quality, and lifestyle choices. Ovarian dysfunction prevalent cause, impacting fertility damaging cells impairing functions. Oxidative stress (OS) condition resulting from an imbalance between natural antioxidants the generation of oxidants. This phenomenon acts double-edged sword, playing crucial role signaling mechanism both physiological pathological processes related to female reproductive system. OS linked ovarian dysfunction, leading cell damage reduced fertility. Nrf2 key regulator oxidative homeostasis, helping defend against improve function women age. Therefore, this review aims highlight system, focusing on its antioxidant properties.

Language: Английский

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Urolithin A Protects Porcine Oocytes from Artificially Induced Oxidative Stress Damage to Enhance Oocyte Maturation and Subsequent Embryo Development

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 3037 - 3037

Published: March 26, 2025

Both the livestock and biomedical fields require a large supply of high-quality mature oocytes. However, in vitro maturation (IVM) process often leads to an accumulation reactive oxygen species (ROS), which can cause defects oocyte meiosis embryo development, ultimately compromising quality. Urolithin A (UA), known for its antioxidant properties, has not been thoroughly investigated potential mitigate negative effects oxidative stress during culturing oocytes, underlying mechanism is well understood. In this study, model was established using porcine oocytes treated with H2O2, followed by exposure varying concentrations UA. The results revealed that 30 μM UA significantly improved both quality culture developmental resulting embryos. found enhance autophagy, reduce stress-induced mitochondrial damage, restore function. Additionally, it lowered ROS DNA damage levels maintained proper spindle/chromosome alignment actin cytoskeleton structure, promoted nuclear maturation, prevented abnormal cortical granule distribution, supported cytoplasmic maturation. As result, alleviated cumulus cell expansion, thereby improving parthenogenetic After supplementation UA, pig pluripotency-related genes (Nanog Sox2) antiapoptotic (Bcl2) were upregulated, while proapoptotic (Bax) downregulated. conclusion, study suggests adding IVM effectively adverse on presenting promising strategy enhancing their vitro.

Language: Английский

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